trichostatin A-2566 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the trichostatin A-2566 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABI2 abl-interactor 2
AKAP4 A kinase (PRKA) anchor protein 4
AMIGO2 adhesion molecule with Ig-like domain 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP10D ATPase, class V, type 10D
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
C11ORF16 chromosome 11 open reading frame 16
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CD59 CD59 molecule, complement regulatory protein
CDC25C cell division cycle 25C
CLGN calmegin
CPM carboxypeptidase M
CRLF1 cytokine receptor-like factor 1
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DFNA5 deafness, autosomal dominant 5
DHRS9 dehydrogenase/reductase (SDR family) member 9
DKK2 dickkopf WNT signaling pathway inhibitor 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNMBP dynamin binding protein
DOCK4 dedicator of cytokinesis 4
DUSP4 dual specificity phosphatase 4
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DZIP3 DAZ interacting zinc finger protein 3
ECI2 enoyl-CoA delta isomerase 2
EPAS1 endothelial PAS domain protein 1
FAM105A family with sequence similarity 105, member A
FAM49A family with sequence similarity 49, member A
FBXL18 F-box and leucine-rich repeat protein 18
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGL1 fibrinogen-like 1
FHL1 four and a half LIM domains 1
FST follistatin
FZD6 frizzled class receptor 6
GCH1 GTP cyclohydrolase 1
GRAMD3 GRAM domain containing 3
GRM1 glutamate receptor, metabotropic 1
HPSE heparanase
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB5 integrin, beta 5
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6
KLF12 Kruppel-like factor 12
LEF1 lymphoid enhancer-binding factor 1
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MTUS1 microtubule associated tumor suppressor 1
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NCAM1 neural cell adhesion molecule 1
NDNF neuron-derived neurotrophic factor
NDRG2 NDRG family member 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPC1 Niemann-Pick disease, type C1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NRCAM neuronal cell adhesion molecule
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PADI2 peptidyl arginine deiminase, type II
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRL platelet-derived growth factor receptor-like
PFN2 profilin 2
PLCD1 phospholipase C, delta 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLS1 plastin 1
PLSCR1 phospholipid scramblase 1
PLSCR3 phospholipid scramblase 3
POU4F1 POU class 4 homeobox 1
PPP5C protein phosphatase 5, catalytic subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RRAGB Ras-related GTP binding B
RRP1B ribosomal RNA processing 1B
RTN2 reticulon 2
SCAND2P SCAN domain containing 2 pseudogene
SGCE sarcoglycan, epsilon
SHOX2 short stature homeobox 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLITRK5 SLIT and NTRK-like family, member 5
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOCS6 suppressor of cytokine signaling 6
SP1 Sp1 transcription factor
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STXBP1 syntaxin binding protein 1
TLN2 talin 2
TMOD1 tropomodulin 1
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TRAF1 TNF receptor-associated factor 1
TSC2 tuberous sclerosis 2
TSC22D1 TSC22 domain family, member 1
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
ZNF215 zinc finger protein 215

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADGB androglobin
AIRE autoimmune regulator
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARID5A AT rich interactive domain 5A (MRF1-like)
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BBC3 BCL2 binding component 3
C5AR1 complement component 5a receptor 1
CAPN5 calpain 5
CD79A CD79a molecule, immunoglobulin-associated alpha
CDH10 cadherin 10, type 2 (T2-cadherin)
CDK3 cyclin-dependent kinase 3
CDON cell adhesion associated, oncogene regulated
CFAP45 cilia and flagella associated protein 45
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CORT cortistatin
CPTP ceramide-1-phosphate transfer protein
CRYGC crystallin, gamma C
CTRL chymotrypsin-like
CXCL2 chemokine (C-X-C motif) ligand 2
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DPYS dihydropyrimidinase
DUSP8 dual specificity phosphatase 8
E2F2 E2F transcription factor 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM50B family with sequence similarity 50, member B
FBXO40 F-box protein 40
FZD4 frizzled class receptor 4
GIPR gastric inhibitory polypeptide receptor
GSN-AS1 GSN antisense RNA 1
GSTT1 glutathione S-transferase theta 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1E histone cluster 1, H1e
HIST1H2AK histone cluster 1, H2ak
HIST1H3G histone cluster 1, H3g
HIST1H3I histone cluster 1, H3i
HP haptoglobin
IFNA17 interferon, alpha 17
IGFBP4 insulin-like growth factor binding protein 4
IGKV3-20 immunoglobulin kappa variable 3-20
IRF2BP1 interferon regulatory factor 2 binding protein 1
JAM3 junctional adhesion molecule 3
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KDM7A lysine (K)-specific demethylase 7A
LIMS2 LIM and senescent cell antigen-like domains 2
LRRC49 leucine rich repeat containing 49
LTBP3 latent transforming growth factor beta binding protein 3
LY6D lymphocyte antigen 6 complex, locus D
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MDM4 MDM4, p53 regulator
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MGLL monoglyceride lipase
MRAS muscle RAS oncogene homolog
MSC musculin
MUC3A mucin 3A, cell surface associated
NPFFR1 neuropeptide FF receptor 1
OLFM4 olfactomedin 4
PAIP2B poly(A) binding protein interacting protein 2B
PBOV1 prostate and breast cancer overexpressed 1
PER3 period circadian clock 3
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PRR7 proline rich 7 (synaptic)
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PYCR1 pyrroline-5-carboxylate reductase 1
RNF126P1 ring finger protein 126 pseudogene 1
SCAMP5 secretory carrier membrane protein 5
SCN10A sodium channel, voltage gated, type X alpha subunit
SLC12A8 solute carrier family 12, member 8
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMR3A submaxillary gland androgen regulated protein 3A
STX5 syntaxin 5
SYTL2 synaptotagmin-like 2
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMC5 transmembrane channel-like 5
TMEM242 transmembrane protein 242
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TPM3 tropomyosin 3
TSC22D4 TSC22 domain family, member 4
TTC27 tetratricopeptide repeat domain 27
VWA1 von Willebrand factor A domain containing 1
ZNF280A zinc finger protein 280A
ZNF668 zinc finger protein 668