trichostatin A-2375 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-2375 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACOX2 acyl-CoA oxidase 2, branched chain
ADD3 adducin 3 (gamma)
ADGRL1 adhesion G protein-coupled receptor L1
AMIGO2 adhesion molecule with Ig-like domain 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C19ORF66 chromosome 19 open reading frame 66
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CCDC28B coiled-coil domain containing 28B
CCKAR cholecystokinin A receptor
CD24 CD24 molecule
CD5 CD5 molecule
CD59 CD59 molecule, complement regulatory protein
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CKB creatine kinase, brain
CX3CR1 chemokine (C-X3-C motif) receptor 1
DFNA5 deafness, autosomal dominant 5
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DST dystonin
DUSP4 dual specificity phosphatase 4
DZIP3 DAZ interacting zinc finger protein 3
ECI2 enoyl-CoA delta isomerase 2
EFNA3 ephrin-A3
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETV1 ets variant 1
EXPH5 exophilin 5
FAM49A family with sequence similarity 49, member A
FAM69A family with sequence similarity 69, member A
FAT2 FAT atypical cadherin 2
FOXO1 forkhead box O1
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GAS6 growth arrest-specific 6
GBP2 guanylate binding protein 2, interferon-inducible
GCH1 GTP cyclohydrolase 1
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
HNF1B HNF1 homeobox B
JAM2 junctional adhesion molecule 2
KIF5C kinesin family member 5C
LINC00652 long intergenic non-protein coding RNA 652
MARCKS myristoylated alanine-rich protein kinase C substrate
MEF2C myocyte enhancer factor 2C
MMP19 matrix metallopeptidase 19
MNX1 motor neuron and pancreas homeobox 1
MPZL1 myelin protein zero-like 1
MTSS1 metastasis suppressor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAM1 neural cell adhesion molecule 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRGN neurogranin (protein kinase C substrate, RC3)
NTS neurotensin
PCGF2 polycomb group ring finger 2
PCNXL2 pecanex-like 2 (Drosophila)
PDE4DIP phosphodiesterase 4D interacting protein
PFN2 profilin 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP prolactin-induced protein
PLCD1 phospholipase C, delta 1
PLXDC1 plexin domain containing 1
POU4F1 POU class 4 homeobox 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRKCQ protein kinase C, theta
RASAL1 RAS protein activator like 1 (GAP1 like)
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RIMS3 regulating synaptic membrane exocytosis 3
RRAS related RAS viral (r-ras) oncogene homolog
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNED1 sushi, nidogen and EGF-like domains 1
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SNX13 sorting nexin 13
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STXBP1 syntaxin binding protein 1
TCEA2 transcription elongation factor A (SII), 2
THAP10 THAP domain containing 10
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TP63 tumor protein p63
TPBG trophoblast glycoprotein
TPMT thiopurine S-methyltransferase
TREM1 triggering receptor expressed on myeloid cells 1
TRH thyrotropin-releasing hormone
TRIM62 tripartite motif containing 62
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TULP3 tubby like protein 3
UBB ubiquitin B
VWA5A von Willebrand factor A domain containing 5A
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF219 zinc finger protein 219

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADI1 acireductone dioxygenase 1
ANKRD55 ankyrin repeat domain 55
ANP32A-IT1 ANP32A intronic transcript 1
ATAD2B ATPase family, AAA domain containing 2B
AVEN apoptosis, caspase activation inhibitor
BPI bactericidal/permeability-increasing protein
C10ORF2 chromosome 10 open reading frame 2
C11ORF68 chromosome 11 open reading frame 68
CAPN5 calpain 5
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX4 chromobox homolog 4
CD14 CD14 molecule
CD244 CD244 molecule, natural killer cell receptor 2B4
CDIP1 cell death-inducing p53 target 1
CISH cytokine inducible SH2-containing protein
CPNE7 copine VII
CPTP ceramide-1-phosphate transfer protein
CXORF21 chromosome X open reading frame 21
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DGAT1 diacylglycerol O-acyltransferase 1
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EMILIN2 elastin microfibril interfacer 2
ERLIN1 ER lipid raft associated 1
FGR FGR proto-oncogene, Src family tyrosine kinase
FXN frataxin
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2I general transcription factor IIi
HAMP hepcidin antimicrobial peptide
HMHA1 histocompatibility (minor) HA-1
HP1BP3 heterochromatin protein 1, binding protein 3
IFITM3 interferon induced transmembrane protein 3
IRF8 interferon regulatory factor 8
ISOC2 isochorismatase domain containing 2
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITPKB inositol-trisphosphate 3-kinase B
JUNB jun B proto-oncogene
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KLF11 Kruppel-like factor 11
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LTBP2 latent transforming growth factor beta binding protein 2
MCRS1 microspherule protein 1
MEPCE methylphosphate capping enzyme
METTL8 methyltransferase like 8
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MON1B MON1 secretory trafficking family member B
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTA2 metastasis associated 1 family, member 2
MTHFSD methenyltetrahydrofolate synthetase domain containing
MXD3 MAX dimerization protein 3
NBEAL2 neurobeachin-like 2
NIP7 NIP7, nucleolar pre-rRNA processing protein
NMI N-myc (and STAT) interactor
NTSR1 neurotensin receptor 1 (high affinity)
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
ODF2 outer dense fiber of sperm tails 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PMCH pro-melanin-concentrating hormone
PMF1 polyamine-modulated factor 1
POM121 POM121 transmembrane nucleoporin
POMZP3 POM121 and ZP3 fusion
PTGES2 prostaglandin E synthase 2
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PUS7 pseudouridylate synthase 7 (putative)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS19 regulator of G-protein signaling 19
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNH1 ribonuclease/angiogenin inhibitor 1
RPP40 ribonuclease P/MRP 40kDa subunit
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SCO2 SCO2 cytochrome c oxidase assembly protein
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SIL1 SIL1 nucleotide exchange factor
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SMYD5 SMYD family member 5
SREK1 splicing regulatory glutamine/lysine-rich protein 1
TCTA T-cell leukemia translocation altered
TERT telomerase reverse transcriptase
TFB2M transcription factor B2, mitochondrial
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TLN1 talin 1
TRIB3 tribbles pseudokinase 3
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA3C tubulin, alpha 3c
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
WDR18 WD repeat domain 18
YIPF1 Yip1 domain family, member 1
ZNF134 zinc finger protein 134
ZNF222 zinc finger protein 222
ZNF322P1 zinc finger protein 322 pseudogene 1
ZNF493 zinc finger protein 493
ZNF692 zinc finger protein 692
ZNF696 zinc finger protein 696
ZNF747 zinc finger protein 747
ZNF804A zinc finger protein 804A