trichostatin A-2370 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the trichostatin A-2370 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACSM5 acyl-CoA synthetase medium-chain family member 5
ADGRL1 adhesion G protein-coupled receptor L1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATP10D ATPase, class V, type 10D
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BBS1 Bardet-Biedl syndrome 1
BLVRA biliverdin reductase A
C1ORF54 chromosome 1 open reading frame 54
CD59 CD59 molecule, complement regulatory protein
CD70 CD70 molecule
CEP162 centrosomal protein 162kDa
CES3 carboxylesterase 3
CKB creatine kinase, brain
CPB1 carboxypeptidase B1 (tissue)
CXADR coxsackie virus and adenovirus receptor
DHRS1 dehydrogenase/reductase (SDR family) member 1
DNM3 dynamin 3
DNMBP dynamin binding protein
DOCK4 dedicator of cytokinesis 4
DSG3 desmoglein 3
DUSP4 dual specificity phosphatase 4
ECI2 enoyl-CoA delta isomerase 2
EFNB2 ephrin-B2
EPAS1 endothelial PAS domain protein 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FLT1 fms-related tyrosine kinase 1
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNS glucosamine (N-acetyl)-6-sulfatase
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
IFI16 interferon, gamma-inducible protein 16
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
ITGA7 integrin, alpha 7
JMJD6 jumonji domain containing 6
JUP junction plakoglobin
KANK2 KN motif and ankyrin repeat domains 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1
KIF1B kinesin family member 1B
KIF5C kinesin family member 5C
LHFP lipoma HMGIC fusion partner
LRRC15 leucine rich repeat containing 15
LY96 lymphocyte antigen 96
MARCKS myristoylated alanine-rich protein kinase C substrate
MPZL1 myelin protein zero-like 1
MTSS1 metastasis suppressor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAV3 neuron navigator 3
NCAM1 neural cell adhesion molecule 1
NPHP1 nephronophthisis 1 (juvenile)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PFN2 profilin 2
PLS1 plastin 1
POU4F1 POU class 4 homeobox 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRDX2 peroxiredoxin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTCRA pre T-cell antigen receptor alpha
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS2 regulator of G-protein signaling 2
RIMS3 regulating synaptic membrane exocytosis 3
RUNX1 runt-related transcription factor 1
SCARB2 scavenger receptor class B, member 2
SCD5 stearoyl-CoA desaturase 5
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SFTPB surfactant protein B
SH3GL3 SH3-domain GRB2-like 3
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SORBS2 sorbin and SH3 domain containing 2
SPINT1 serine peptidase inhibitor, Kunitz type 1
SSH3 slingshot protein phosphatase 3
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STXBP1 syntaxin binding protein 1
SYNE1 spectrin repeat containing, nuclear envelope 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TECPR2 tectonin beta-propeller repeat containing 2
THAP10 THAP domain containing 10
TLN2 talin 2
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPBG trophoblast glycoprotein
TPST1 tyrosylprotein sulfotransferase 1
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
ULBP2 UL16 binding protein 2
VWA5A von Willebrand factor A domain containing 5A
WDR19 WD repeat domain 19
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZC3H7B zinc finger CCCH-type containing 7B
ZCCHC24 zinc finger, CCHC domain containing 24
ZFHX2 zinc finger homeobox 2
ZNF235 zinc finger protein 235
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AEN apoptosis enhancing nuclease
AHCTF1 AT hook containing transcription factor 1
ASTE1 asteroid homolog 1 (Drosophila)
BANP BTG3 associated nuclear protein
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRD9 bromodomain containing 9
C19ORF24 chromosome 19 open reading frame 24
C1ORF123 chromosome 1 open reading frame 123
C2CD2 C2 calcium-dependent domain containing 2
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CD14 CD14 molecule
CERS2 ceramide synthase 2
CISH cytokine inducible SH2-containing protein
CLEC5A C-type lectin domain family 5, member A
CLTCL1 clathrin, heavy chain-like 1
CSK c-src tyrosine kinase
CST7 cystatin F (leukocystatin)
CTPS1 CTP synthase 1
CYBRD1 cytochrome b reductase 1
DCPS decapping enzyme, scavenger
DCTPP1 dCTP pyrophosphatase 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DENND4B DENN/MADD domain containing 4B
ECI1 enoyl-CoA delta isomerase 1
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ENDOG endonuclease G
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
FAM136A family with sequence similarity 136, member A
FAM172A family with sequence similarity 172, member A
FAM57A family with sequence similarity 57, member A
FAM86B1 family with sequence similarity 86, member B1
FJX1 four jointed box 1 (Drosophila)
FMNL1 formin-like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAR1 GAR1 ribonucleoprotein
GBE1 glucan (1,4-alpha-), branching enzyme 1
GYPC glycophorin C (Gerbich blood group)
HP haptoglobin
HPS6 Hermansky-Pudlak syndrome 6
HRAS Harvey rat sarcoma viral oncogene homolog
IPO4 importin 4
JMJD4 jumonji domain containing 4
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
MBIP MAP3K12 binding inhibitory protein 1
MCM9 minichromosome maintenance complex component 9
MCRS1 microspherule protein 1
MEPCE methylphosphate capping enzyme
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MICALL1 MICAL-like 1
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NOL6 nucleolar protein 6 (RNA-associated)
NUBPL nucleotide binding protein-like
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
ORAI3 ORAI calcium release-activated calcium modulator 3
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLK1 polo-like kinase 1
PMF1 polyamine-modulated factor 1
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRDM13 PR domain containing 13
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PTS 6-pyruvoyltetrahydropterin synthase
PUS1 pseudouridylate synthase 1
RAB3A RAB3A, member RAS oncogene family
RGS19 regulator of G-protein signaling 19
RPP38 ribonuclease P/MRP 38kDa subunit
RPP40 ribonuclease P/MRP 40kDa subunit
SARS2 seryl-tRNA synthetase 2, mitochondrial
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SEPHS1 selenophosphate synthetase 1
SFT2D2 SFT2 domain containing 2
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNHG3 small nucleolar RNA host gene 3
TMEM164 transmembrane protein 164
TMEM223 transmembrane protein 223
TRABD TraB domain containing
TRIB3 tribbles pseudokinase 3
UBTF upstream binding transcription factor, RNA polymerase I
UNKL unkempt family zinc finger-like
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VILL villin-like
VWA9 von Willebrand factor A domain containing 9
WDR43 WD repeat domain 43
XAB2 XPA binding protein 2
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF408 zinc finger protein 408
ZNF593 zinc finger protein 593
ZNF629 zinc finger protein 629
ZNF804A zinc finger protein 804A