trichostatin A-2268 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the trichostatin A-2268 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
ANG angiogenin, ribonuclease, RNase A family, 5
ARMCX2 armadillo repeat containing, X-linked 2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
BEX4 brain expressed, X-linked 4
BTN2A2 butyrophilin, subfamily 2, member A2
CASC1 cancer susceptibility candidate 1
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CLGN calmegin
CORO1A coronin, actin binding protein, 1A
CSRP2 cysteine and glycine-rich protein 2
CXADR coxsackie virus and adenovirus receptor
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLX2 distal-less homeobox 2
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPYSL4 dihydropyrimidinase-like 4
EFNB3 ephrin-B3
ELOVL4 ELOVL fatty acid elongase 4
ETV5 ets variant 5
FKBP1B FK506 binding protein 1B, 12.6 kDa
FYN FYN proto-oncogene, Src family tyrosine kinase
GEM GTP binding protein overexpressed in skeletal muscle
GLDC glycine dehydrogenase (decarboxylating)
GLRX glutaredoxin (thioltransferase)
GMPR guanosine monophosphate reductase
GRK5 G protein-coupled receptor kinase 5
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IFI6 interferon, alpha-inducible protein 6
IL21R interleukin 21 receptor
ITM2C integral membrane protein 2C
KIAA0513 KIAA0513
KIF21B kinesin family member 21B
LINC00341 long intergenic non-protein coding RNA 341
LYST lysosomal trafficking regulator
MAP1B microtubule-associated protein 1B
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARK4 MAP/microtubule affinity-regulating kinase 4
MLF1 myeloid leukemia factor 1
MMD monocyte to macrophage differentiation-associated
MUC3B mucin 3B, cell surface associated
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NME5 NME/NM23 family member 5
NR4A3 nuclear receptor subfamily 4, group A, member 3
NR6A1 nuclear receptor subfamily 6, group A, member 1
NSUN6 NOP2/Sun domain family, member 6
OPTN optineurin
PADI3 peptidyl arginine deiminase, type III
PAIP2B poly(A) binding protein interacting protein 2B
PDE4DIP phosphodiesterase 4D interacting protein
PEG10 paternally expressed 10
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PRPH peripherin
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTRF polymerase I and transcript release factor
RAI2 retinoic acid induced 2
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
REEP1 receptor accessory protein 1
RGCC regulator of cell cycle
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN2 reticulon 2
RUNDC3B RUN domain containing 3B
SEPP1 selenoprotein P, plasma, 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SIRT4 sirtuin 4
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLCO4C1 solute carrier organic anion transporter family, member 4C1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAT4 signal transducer and activator of transcription 4
STON1 stonin 1
SYT11 synaptotagmin XI
TRIM2 tripartite motif containing 2
TUBA4A tubulin, alpha 4a
TXNIP thioredoxin interacting protein
ULBP2 UL16 binding protein 2
USP2 ubiquitin specific peptidase 2
WDR19 WD repeat domain 19
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF204P zinc finger protein 204, pseudogene

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACVR2B activin A receptor, type IIB
ADNP activity-dependent neuroprotector homeobox
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BRD9 bromodomain containing 9
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C5AR2 complement component 5a receptor 2
CALHM2 calcium homeostasis modulator 2
CASD1 CAS1 domain containing 1
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCND1 cyclin D1
CHKB choline kinase beta
CXCL12 chemokine (C-X-C motif) ligand 12
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
EGR3 early growth response 3
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ESRP2 epithelial splicing regulatory protein 2
FAM57A family with sequence similarity 57, member A
FJX1 four jointed box 1 (Drosophila)
FOXI1 forkhead box I1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GFRA1 GDNF family receptor alpha 1
GPATCH3 G patch domain containing 3
GTF2I general transcription factor IIi
HIRIP3 HIRA interacting protein 3
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
IRX5 iroquois homeobox 5
ITPKB inositol-trisphosphate 3-kinase B
KAT6B K(lysine) acetyltransferase 6B
KEAP1 kelch-like ECH-associated protein 1
KLC2 kinesin light chain 2
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRC41 leucine rich repeat containing 41
LUC7L2 LUC7-like 2 (S. cerevisiae)
LY6D lymphocyte antigen 6 complex, locus D
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MCM9 minichromosome maintenance complex component 9
MEPCE methylphosphate capping enzyme
METTL1 methyltransferase like 1
MSL1 male-specific lethal 1 homolog (Drosophila)
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MYD88 myeloid differentiation primary response 88
NIPAL2 NIPA-like domain containing 2
NLRX1 NLR family member X1
NMI N-myc (and STAT) interactor
NOL12 nucleolar protein 12
NSD1 nuclear receptor binding SET domain protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PHLDA3 pleckstrin homology-like domain, family A, member 3
POLL polymerase (DNA directed), lambda
PRR15L proline rich 15-like
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SFMBT1 Scm-like with four mbt domains 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMG9 SMG9 nonsense mediated mRNA decay factor
SNHG20 small nucleolar RNA host gene 20
SNHG3 small nucleolar RNA host gene 3
SOX12 SRY (sex determining region Y)-box 12
SPHK1 sphingosine kinase 1
SPIN1 spindlin 1
SREK1 splicing regulatory glutamine/lysine-rich protein 1
STAG1 stromal antigen 1
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TDRD3 tudor domain containing 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TRIB3 tribbles pseudokinase 3
TRIM8 tripartite motif containing 8
UBTF upstream binding transcription factor, RNA polymerase I
UBXN8 UBX domain protein 8
UNKL unkempt family zinc finger-like
VRK2 vaccinia related kinase 2
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
XBP1 X-box binding protein 1
YAP1 Yes-associated protein 1
ZBED1 zinc finger, BED-type containing 1
ZBED5 zinc finger, BED-type containing 5
ZBTB3 zinc finger and BTB domain containing 3
ZHX2 zinc fingers and homeoboxes 2
ZIC1 Zic family member 1
ZNF428 zinc finger protein 428
ZNF692 zinc finger protein 692
ZNHIT2 zinc finger, HIT-type containing 2