trichostatin A-2105 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-2105 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
AKAP13 A kinase (PRKA) anchor protein 13
ANGPTL4 angiopoietin-like 4
AQP3 aquaporin 3 (Gill blood group)
ARHGAP26 Rho GTPase activating protein 26
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASMTL acetylserotonin O-methyltransferase-like
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AVPI1 arginine vasopressin-induced 1
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
CACYBP calcyclin binding protein
CCNA1 cyclin A1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFAP69 cilia and flagella associated protein 69
CHN2 chimerin 2
CLDN8 claudin 8
CORO1A coronin, actin binding protein, 1A
CPA4 carboxypeptidase A4
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
DENND3 DENN/MADD domain containing 3
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DZIP1 DAZ interacting zinc finger protein 1
EFNA3 ephrin-A3
EFNB2 ephrin-B2
EGR2 early growth response 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMP1 epithelial membrane protein 1
EPHA4 EPH receptor A4
EPHB3 EPH receptor B3
EPPK1 epiplakin 1
FABP4 fatty acid binding protein 4, adipocyte
FAM69A family with sequence similarity 69, member A
FGFBP1 fibroblast growth factor binding protein 1
FLRT3 fibronectin leucine rich transmembrane protein 3
GMPR guanosine monophosphate reductase
GTF2B general transcription factor IIB
GUCY1B3 guanylate cyclase 1, soluble, beta 3
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HSF2 heat shock transcription factor 2
IL1RAP interleukin 1 receptor accessory protein
ING1 inhibitor of growth family, member 1
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INSIG1 insulin induced gene 1
IRF6 interferon regulatory factor 6
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0513 KIAA0513
KIF5C kinesin family member 5C
LMCD1 LIM and cysteine-rich domains 1
LPPR4 lipid phosphate phosphatase-related protein type 4
LYPD3 LY6/PLAUR domain containing 3
MERTK MER proto-oncogene, tyrosine kinase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MMP1 matrix metallopeptidase 1
MMP16 matrix metallopeptidase 16 (membrane-inserted)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NIT1 nitrilase 1
OASL 2'-5'-oligoadenylate synthetase-like
PCDH9 protocadherin 9
PDPK1 3-phosphoinositide dependent protein kinase 1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PPL periplakin
PRKCD protein kinase C, delta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAI2 retinoic acid induced 2
RBMS2 RNA binding motif, single stranded interacting protein 2
RGCC regulator of cell cycle
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS17 regulator of G-protein signaling 17
RGS4 regulator of G-protein signaling 4
RWDD2A RWD domain containing 2A
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SSBP2 single-stranded DNA binding protein 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STARD5 StAR-related lipid transfer (START) domain containing 5
STC1 stanniocalcin 1
SYT1 synaptotagmin I
TAGLN3 transgelin 3
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNIK TRAF2 and NCK interacting kinase
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
WDR91 WD repeat domain 91

decreased expression

Symbol Name
ADCY7 adenylate cyclase 7
ADNP activity-dependent neuroprotector homeobox
AMIGO2 adhesion molecule with Ig-like domain 2
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARHGAP11A Rho GTPase activating protein 11A
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ATF1 activating transcription factor 1
BCAR3 breast cancer anti-estrogen resistance 3
C10ORF88 chromosome 10 open reading frame 88
C17ORF75 chromosome 17 open reading frame 75
C17ORF85 chromosome 17 open reading frame 85
C2CD5 C2 calcium-dependent domain containing 5
CBR3 carbonyl reductase 3
CCDC59 coiled-coil domain containing 59
CDC7 cell division cycle 7
CHKB choline kinase beta
CLCF1 cardiotrophin-like cytokine factor 1
COG4 component of oligomeric golgi complex 4
CUL1 cullin 1
DEPDC1 DEP domain containing 1
FAIM Fas apoptotic inhibitory molecule
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
FST follistatin
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GPRC5C G protein-coupled receptor, class C, group 5, member C
H2AFY2 H2A histone family, member Y2
HAS2 hyaluronan synthase 2
HMGA2 high mobility group AT-hook 2
INHBB inhibin, beta B
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IPP intracisternal A particle-promoted polypeptide
ITPKB inositol-trisphosphate 3-kinase B
KAT5 K(lysine) acetyltransferase 5
KAT6B K(lysine) acetyltransferase 6B
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KIF15 kinesin family member 15
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LIF leukemia inhibitory factor
LMNB1 lamin B1
LMNB2 lamin B2
LOXL1 lysyl oxidase-like 1
LPAR1 lysophosphatidic acid receptor 1
LRIF1 ligand dependent nuclear receptor interacting factor 1
LYPD1 LY6/PLAUR domain containing 1
MEPCE methylphosphate capping enzyme
METTL1 methyltransferase like 1
METTL4 methyltransferase like 4
MISP mitotic spindle positioning
MSL1 male-specific lethal 1 homolog (Drosophila)
MTERF1 mitochondrial transcription termination factor 1
NDC80 NDC80 kinetochore complex component
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NME6 NME/NM23 nucleoside diphosphate kinase 6
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PHF11 PHD finger protein 11
PLK1 polo-like kinase 1
PNISR PNN-interacting serine/arginine-rich protein
RBL1 retinoblastoma-like 1
RIN2 Ras and Rab interactor 2
SCAF8 SR-related CTD-associated factor 8
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETD1B SET domain containing 1B
SKA1 spindle and kinetochore associated complex subunit 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLTM SAFB-like, transcription modulator
SMAGP small cell adhesion glycoprotein
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SPHK1 sphingosine kinase 1
SRSF4 serine/arginine-rich splicing factor 4
STXBP3 syntaxin binding protein 3
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THAP1 THAP domain containing, apoptosis associated protein 1
TMEM168 transmembrane protein 168
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRAPPC12 trafficking protein particle complex 12
TRIB3 tribbles pseudokinase 3
UBXN8 UBX domain protein 8
USP21 ubiquitin specific peptidase 21
VEGFC vascular endothelial growth factor C
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
ZBED1 zinc finger, BED-type containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZC3H7A zinc finger CCCH-type containing 7A
ZMYM3 zinc finger, MYM-type 3
ZNF165 zinc finger protein 165
ZNF692 zinc finger protein 692
ZZZ3 zinc finger, ZZ-type containing 3