trichostatin A-2084 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-2084 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADRB2 adrenoceptor beta 2, surface
ANGPTL4 angiopoietin-like 4
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARHGAP6 Rho GTPase activating protein 6
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASMTL acetylserotonin O-methyltransferase-like
ATG2A autophagy related 2A
AVPI1 arginine vasopressin-induced 1
BAIAP2 BAI1-associated protein 2
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BMP6 bone morphogenetic protein 6
CCL20 chemokine (C-C motif) ligand 20
CCNA1 cyclin A1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CLDN8 claudin 8
CORO1A coronin, actin binding protein, 1A
CPA4 carboxypeptidase A4
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCR4 chemokine (C-X-C motif) receptor 4
DENND3 DENN/MADD domain containing 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNA3 ephrin-A3
EFNB2 ephrin-B2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELOVL4 ELOVL fatty acid elongase 4
EPPK1 epiplakin 1
FABP4 fatty acid binding protein 4, adipocyte
FLRT3 fibronectin leucine rich transmembrane protein 3
GCDH glutaryl-CoA dehydrogenase
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLCE glucuronic acid epimerase
GLRX glutaredoxin (thioltransferase)
GMCL1 germ cell-less, spermatogenesis associated 1
GMPR guanosine monophosphate reductase
H1FX H1 histone family, member X
HOXA1 homeobox A1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IL11 interleukin 11
INSIG1 insulin induced gene 1
IRF6 interferon regulatory factor 6
IRS2 insulin receptor substrate 2
KIF5C kinesin family member 5C
LMCD1 LIM and cysteine-rich domains 1
LPPR4 lipid phosphate phosphatase-related protein type 4
LYPD3 LY6/PLAUR domain containing 3
MAP2K3 mitogen-activated protein kinase kinase 3
MCTP1 multiple C2 domains, transmembrane 1
MCTP2 multiple C2 domains, transmembrane 2
MERTK MER proto-oncogene, tyrosine kinase
MLF1 myeloid leukemia factor 1
MMP1 matrix metallopeptidase 1
MMP16 matrix metallopeptidase 16 (membrane-inserted)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
OASL 2'-5'-oligoadenylate synthetase-like
PCDH9 protocadherin 9
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTX3 pentraxin 3, long
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RNF24 ring finger protein 24
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SLC25A44 solute carrier family 25, member 44
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SQLE squalene epoxidase
SSBP2 single-stranded DNA binding protein 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
SUGP1 SURP and G patch domain containing 1
SYT1 synaptotagmin I
TAOK3 TAO kinase 3
TBPL1 TBP-like 1
TESK2 testis-specific kinase 2
TNIK TRAF2 and NCK interacting kinase
TPST2 tyrosylprotein sulfotransferase 2
TRAFD1 TRAF-type zinc finger domain containing 1
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ADORA2B adenosine A2b receptor
AKAP8 A kinase (PRKA) anchor protein 8
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASTE1 asteroid homolog 1 (Drosophila)
ATAD2B ATPase family, AAA domain containing 2B
ATF1 activating transcription factor 1
AXIN1 axin 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BCAR3 breast cancer anti-estrogen resistance 3
BRD1 bromodomain containing 1
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CBR3 carbonyl reductase 3
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CLCF1 cardiotrophin-like cytokine factor 1
COA7 cytochrome c oxidase assembly factor 7 (putative)
CUL1 cullin 1
CYTH2 cytohesin 2
DEPDC1 DEP domain containing 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
E2F8 E2F transcription factor 8
FADD Fas (TNFRSF6)-associated via death domain
FAM111A family with sequence similarity 111, member A
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
FST follistatin
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GBX2 gastrulation brain homeobox 2
GPR87 G protein-coupled receptor 87
HAS2 hyaluronan synthase 2
HMGA2 high mobility group AT-hook 2
IL4R interleukin 4 receptor
IL7R interleukin 7 receptor
IMPACT impact RWD domain protein
INHBB inhibin, beta B
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IPP intracisternal A particle-promoted polypeptide
KAT6B K(lysine) acetyltransferase 6B
KEAP1 kelch-like ECH-associated protein 1
LIF leukemia inhibitory factor
LMNB1 lamin B1
LPAR1 lysophosphatidic acid receptor 1
LUC7L2 LUC7-like 2 (S. cerevisiae)
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MEPCE methylphosphate capping enzyme
METTL1 methyltransferase like 1
METTL8 methyltransferase like 8
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MSL1 male-specific lethal 1 homolog (Drosophila)
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NLRX1 NLR family member X1
NME6 NME/NM23 nucleoside diphosphate kinase 6
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NSD1 nuclear receptor binding SET domain protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
PALB2 partner and localizer of BRCA2
PARP12 poly (ADP-ribose) polymerase family, member 12
PDLIM2 PDZ and LIM domain 2 (mystique)
PEF1 penta-EF-hand domain containing 1
PHF11 PHD finger protein 11
PLK1 polo-like kinase 1
POGK pogo transposable element with KRAB domain
PPAN peter pan homolog (Drosophila)
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PXDC1 PX domain containing 1
RBM4B RNA binding motif protein 4B
RIN2 Ras and Rab interactor 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETD1B SET domain containing 1B
SETMAR SET domain and mariner transposase fusion gene
SFMBT1 Scm-like with four mbt domains 1
SH2D4A SH2 domain containing 4A
SIM2 single-minded family bHLH transcription factor 2
SLTM SAFB-like, transcription modulator
SMAGP small cell adhesion glycoprotein
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMYD5 SMYD family member 5
SNUPN snurportin 1
SRSF4 serine/arginine-rich splicing factor 4
STBD1 starch binding domain 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMEM39B transmembrane protein 39B
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIOBP TRIO and F-actin binding protein
USP21 ubiquitin specific peptidase 21
VEGFC vascular endothelial growth factor C
VWA9 von Willebrand factor A domain containing 9
WBSCR16 Williams-Beuren syndrome chromosome region 16
XBP1 X-box binding protein 1
ZBED1 zinc finger, BED-type containing 1
ZNF165 zinc finger protein 165
ZNF692 zinc finger protein 692
ZZZ3 zinc finger, ZZ-type containing 3