trichostatin A-1891 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-1891 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
AHR aryl hydrocarbon receptor
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARL4D ADP-ribosylation factor-like 4D
BAIAP2 BAI1-associated protein 2
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BLVRA biliverdin reductase A
C18ORF8 chromosome 18 open reading frame 8
C2CD2L C2CD2-like
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP68 centrosomal protein 68kDa
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRY1 cryptochrome circadian clock 1
CSNK1E casein kinase 1, epsilon
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXADR coxsackie virus and adenovirus receptor
CYR61 cysteine-rich, angiogenic inducer, 61
DAAM1 dishevelled associated activator of morphogenesis 1
DENND3 DENN/MADD domain containing 3
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNB2 ephrin-B2
EGR2 early growth response 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMP1 epithelial membrane protein 1
EVI5 ecotropic viral integration site 5
F2R coagulation factor II (thrombin) receptor
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FAM188A family with sequence similarity 188, member A
FBXO3 F-box protein 3
FLRT3 fibronectin leucine rich transmembrane protein 3
GLRX glutaredoxin (thioltransferase)
GTF2B general transcription factor IIB
GUCY1B3 guanylate cyclase 1, soluble, beta 3
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2AG histone cluster 1, H2ag
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL11 interleukin 11
INSIG1 insulin induced gene 1
IRF6 interferon regulatory factor 6
IRS2 insulin receptor substrate 2
KDM4B lysine (K)-specific demethylase 4B
KIF5C kinesin family member 5C
KLF5 Kruppel-like factor 5 (intestinal)
LMCD1 LIM and cysteine-rich domains 1
LPIN1 lipin 1
LYST lysosomal trafficking regulator
MAP2K3 mitogen-activated protein kinase kinase 3
MBNL2 muscleblind-like splicing regulator 2
MICA MHC class I polypeptide-related sequence A
MLF1 myeloid leukemia factor 1
MMP1 matrix metallopeptidase 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NTF3 neurotrophin 3
PELI1 pellino E3 ubiquitin protein ligase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RNF24 ring finger protein 24
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNX1 sorting nexin 1
SOD2 superoxide dismutase 2, mitochondrial
SQLE squalene epoxidase
STC1 stanniocalcin 1
TAGLN3 transgelin 3
TAOK3 TAO kinase 3
TBPL1 TBP-like 1
TGFBR3 transforming growth factor, beta receptor III
TPST2 tyrosylprotein sulfotransferase 2
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ABT1 activator of basal transcription 1
ADNP activity-dependent neuroprotector homeobox
ADORA2B adenosine A2b receptor
AKAP8 A kinase (PRKA) anchor protein 8
ATF1 activating transcription factor 1
BCAR3 breast cancer anti-estrogen resistance 3
BCL7A B-cell CLL/lymphoma 7A
BRIX1 BRX1, biogenesis of ribosomes
C2CD5 C2 calcium-dependent domain containing 5
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CBR3 carbonyl reductase 3
CLCF1 cardiotrophin-like cytokine factor 1
CLK2 CDC-like kinase 2
COIL coilin
CTCF CCCTC-binding factor (zinc finger protein)
CUL1 cullin 1
EXOSC10 exosome component 10
FADD Fas (TNFRSF6)-associated via death domain
FAM60A family with sequence similarity 60, member A
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
FST follistatin
GEMIN4 gem (nuclear organelle) associated protein 4
H2AFY2 H2A histone family, member Y2
HAS2 hyaluronan synthase 2
HMGA2 high mobility group AT-hook 2
HNRNPF heterogeneous nuclear ribonucleoprotein F
IL6 interleukin 6
IL7R interleukin 7 receptor
INHBB inhibin, beta B
KEAP1 kelch-like ECH-associated protein 1
LIF leukemia inhibitory factor
LINC00339 long intergenic non-protein coding RNA 339
LMNB1 lamin B1
LRIF1 ligand dependent nuclear receptor interacting factor 1
MARC1 mitochondrial amidoxime reducing component 1
MEPCE methylphosphate capping enzyme
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MOCOS molybdenum cofactor sulfurase
MTIF2 mitochondrial translational initiation factor 2
NCAPH non-SMC condensin I complex, subunit H
NCOA6 nuclear receptor coactivator 6
NLRX1 NLR family member X1
NMI N-myc (and STAT) interactor
NUAK1 NUAK family, SNF1-like kinase, 1
NUP62 nucleoporin 62kDa
PEF1 penta-EF-hand domain containing 1
PEX12 peroxisomal biogenesis factor 12
PLAU plasminogen activator, urokinase
PMM2 phosphomannomutase 2
POGK pogo transposable element with KRAB domain
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
PPAN peter pan homolog (Drosophila)
PRCC papillary renal cell carcinoma (translocation-associated)
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAP1GAP2 RAP1 GTPase activating protein 2
RBM10 RNA binding motif protein 10
RBM23 RNA binding motif protein 23
RBM39 RNA binding motif protein 39
RIN2 Ras and Rab interactor 2
RNF220 ring finger protein 220
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
SCAF8 SR-related CTD-associated factor 8
SCO2 SCO2 cytochrome c oxidase assembly protein
SCRN1 secernin 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SMAGP small cell adhesion glycoprotein
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
SNUPN snurportin 1
SPOP speckle-type POZ protein
SRSF4 serine/arginine-rich splicing factor 4
STXBP3 syntaxin binding protein 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TMEM168 transmembrane protein 168
TMEM185B transmembrane protein 185B
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRAPPC12 trafficking protein particle complex 12
TRIM68 tripartite motif containing 68
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae)
TSSC4 tumor suppressing subtransferable candidate 4
TTC4 tetratricopeptide repeat domain 4
UNC50 unc-50 homolog (C. elegans)
USP21 ubiquitin specific peptidase 21
VEGFC vascular endothelial growth factor C
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WBSCR16 Williams-Beuren syndrome chromosome region 16
WDR6 WD repeat domain 6
WDR74 WD repeat domain 74
XBP1 X-box binding protein 1
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZC3H4 zinc finger CCCH-type containing 4
ZC3H7A zinc finger CCCH-type containing 7A
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF175 zinc finger protein 175
ZNF532 zinc finger protein 532