trichostatin A-1561 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the trichostatin A-1561 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABI2 abl-interactor 2
ACP6 acid phosphatase 6, lysophosphatidic
ADD3 adducin 3 (gamma)
AGFG1 ArfGAP with FG repeats 1
AGRP agouti related neuropeptide
AHR aryl hydrocarbon receptor
AMIGO2 adhesion molecule with Ig-like domain 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASMTL acetylserotonin O-methyltransferase-like
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BCL6 B-cell CLL/lymphoma 6
C19ORF66 chromosome 19 open reading frame 66
CACYBP calcyclin binding protein
CANT1 calcium activated nucleotidase 1
CAST calpastatin
CCL20 chemokine (C-C motif) ligand 20
CCS copper chaperone for superoxide dismutase
CCSER2 coiled-coil serine-rich protein 2
CD59 CD59 molecule, complement regulatory protein
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CREB3 cAMP responsive element binding protein 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYLD cylindromatosis (turban tumor syndrome)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAAM1 dishevelled associated activator of morphogenesis 1
DHRS1 dehydrogenase/reductase (SDR family) member 1
DPYD dihydropyrimidine dehydrogenase
DSE dermatan sulfate epimerase
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ECI2 enoyl-CoA delta isomerase 2
ELMO2 engulfment and cell motility 2
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
EVI5 ecotropic viral integration site 5
F11R F11 receptor
FAM13A family with sequence similarity 13, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR1 fibroblast growth factor receptor 1
FIG4 FIG4 phosphoinositide 5-phosphatase
FUCA1 fucosidase, alpha-L- 1, tissue
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GCH1 GTP cyclohydrolase 1
GPR65 G protein-coupled receptor 65
GPSM3 G-protein signaling modulator 3
HCAR3 hydroxycarboxylic acid receptor 3
HDAC5 histone deacetylase 5
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HTATSF1 HIV-1 Tat specific factor 1
HTT huntingtin
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JRKL JRK-like
JUN jun proto-oncogene
KDM5A lysine (K)-specific demethylase 5A
LAD1 ladinin 1
LMAN2L lectin, mannose-binding 2-like
LTA4H leukotriene A4 hydrolase
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARK4 MAP/microtubule affinity-regulating kinase 4
MCL1 myeloid cell leukemia 1
METTL7A methyltransferase like 7A
MMP2 matrix metallopeptidase 2
NCOA3 nuclear receptor coactivator 3
NME7 NME/NM23 family member 7
NMRK1 nicotinamide riboside kinase 1
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
PCGF2 polycomb group ring finger 2
PCNXL2 pecanex-like 2 (Drosophila)
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE4DIP phosphodiesterase 4D interacting protein
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLS1 plastin 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRDM2 PR domain containing 2, with ZNF domain
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTK2 protein tyrosine kinase 2
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
RABAC1 Rab acceptor 1 (prenylated)
RPL13P5 ribosomal protein L13 pseudogene 5
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STXBP1 syntaxin binding protein 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TSPAN13 tetraspanin 13
TUFT1 tuftelin 1
TUSC2 tumor suppressor candidate 2
WDR48 WD repeat domain 48

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADI1 acireductone dioxygenase 1
ALPK1 alpha-kinase 1
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C4ORF29 chromosome 4 open reading frame 29
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAMTA2 calmodulin binding transcription activator 2
CARD9 caspase recruitment domain family, member 9
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CBS cystathionine-beta-synthase
CCDC130 coiled-coil domain containing 130
CDC23 cell division cycle 23
CEND1 cell cycle exit and neuronal differentiation 1
CER1 cerberus 1, DAN family BMP antagonist
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIDEB cell death-inducing DFFA-like effector b
CISH cytokine inducible SH2-containing protein
CNOT6 CCR4-NOT transcription complex, subunit 6
CNPY3 canopy FGF signaling regulator 3
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FAM136A family with sequence similarity 136, member A
FAM50B family with sequence similarity 50, member B
FAM53B family with sequence similarity 53, member B
FAN1 FANCD2/FANCI-associated nuclease 1
FMNL1 formin-like 1
GALNS galactosamine (N-acetyl)-6-sulfatase
GATAD2A GATA zinc finger domain containing 2A
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GGTLC1 gamma-glutamyltransferase light chain 1
GPR27 G protein-coupled receptor 27
GRAMD4 GRAM domain containing 4
GUSBP3 glucuronidase, beta pseudogene 3
IFRD2 interferon-related developmental regulator 2
INO80D INO80 complex subunit D
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KAT2A K(lysine) acetyltransferase 2A
KIAA0196 KIAA0196
KIAA0894 KIAA0894 protein
KIAA1551 KIAA1551
KLHL21 kelch-like family member 21
LARP1 La ribonucleoprotein domain family, member 1
LRP5L low density lipoprotein receptor-related protein 5-like
MAPK12 mitogen-activated protein kinase 12
MATK megakaryocyte-associated tyrosine kinase
MBOAT2 membrane bound O-acyltransferase domain containing 2
MOGS mannosyl-oligosaccharide glucosidase
MRPS27 mitochondrial ribosomal protein S27
MTM1 myotubularin 1
MUC3A mucin 3A, cell surface associated
NHEJ1 nonhomologous end-joining factor 1
NUCB2 nucleobindin 2
PAK1IP1 PAK1 interacting protein 1
PEMT phosphatidylethanolamine N-methyltransferase
PES1 pescadillo ribosomal biogenesis factor 1
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PNRC1 proline-rich nuclear receptor coactivator 1
PODNL1 podocan-like 1
POTEKP POTE ankyrin domain family, member K, pseudogene
PRMT3 protein arginine methyltransferase 3
PTGES2 prostaglandin E synthase 2
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PUS7 pseudouridylate synthase 7 (putative)
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
PYCR1 pyrroline-5-carboxylate reductase 1
RNF44 ring finger protein 44
RPL23AP32 ribosomal protein L23a pseudogene 32
SCO2 SCO2 cytochrome c oxidase assembly protein
SEH1L SEH1-like (S. cerevisiae)
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SNHG3 small nucleolar RNA host gene 3
SNX17 sorting nexin 17
SPAG7 sperm associated antigen 7
SPON2 spondin 2, extracellular matrix protein
STEAP3 STEAP family member 3, metalloreductase
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBL3 transducin (beta)-like 3
TEFM transcription elongation factor, mitochondrial
TERT telomerase reverse transcriptase
TLN1 talin 1
TOP2B topoisomerase (DNA) II beta 180kDa
TPCN1 two pore segment channel 1
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
WDR74 WD repeat domain 74
WDR82 WD repeat domain 82
XPOT exportin, tRNA
ZNF282 zinc finger protein 282