trichostatin A-1234 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the trichostatin A-1234 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD17B abhydrolase domain containing 17B
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
ANGPTL4 angiopoietin-like 4
AQP3 aquaporin 3 (Gill blood group)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASMTL acetylserotonin O-methyltransferase-like
BAIAP2 BAI1-associated protein 2
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
C2CD2L C2CD2-like
CCL20 chemokine (C-C motif) ligand 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP76 centrosomal protein 76kDa
CFAP69 cilia and flagella associated protein 69
CHN2 chimerin 2
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CTNS cystinosin, lysosomal cystine transporter
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DENND3 DENN/MADD domain containing 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNB2 ephrin-B2
EGR2 early growth response 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELOVL4 ELOVL fatty acid elongase 4
EPHB3 EPH receptor B3
EPPK1 epiplakin 1
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FLRT3 fibronectin leucine rich transmembrane protein 3
GLRX glutaredoxin (thioltransferase)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTF2B general transcription factor IIB
H1FX H1 histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA2 heat shock 70kDa protein 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IL1RAP interleukin 1 receptor accessory protein
INSIG1 insulin induced gene 1
IRF6 interferon regulatory factor 6
IRS2 insulin receptor substrate 2
LINC00312 long intergenic non-protein coding RNA 312
LINC00341 long intergenic non-protein coding RNA 341
LMCD1 LIM and cysteine-rich domains 1
LPIN1 lipin 1
LPPR4 lipid phosphate phosphatase-related protein type 4
MAP2K3 mitogen-activated protein kinase kinase 3
MERTK MER proto-oncogene, tyrosine kinase
MICA MHC class I polypeptide-related sequence A
MMP1 matrix metallopeptidase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NR4A2 nuclear receptor subfamily 4, group A, member 2
OASL 2'-5'-oligoadenylate synthetase-like
PCDH9 protocadherin 9
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PKP2 plakophilin 2
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAI2 retinoic acid induced 2
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RND1 Rho family GTPase 1
RNF19B ring finger protein 19B
RNF24 ring finger protein 24
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SQLE squalene epoxidase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STK17B serine/threonine kinase 17b
TBPL1 TBP-like 1
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
WDR19 WD repeat domain 19
ZNF217 zinc finger protein 217

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADNP activity-dependent neuroprotector homeobox
ARSJ arylsulfatase family, member J
ATF1 activating transcription factor 1
BANP BTG3 associated nuclear protein
BCAR3 breast cancer anti-estrogen resistance 3
BCL7A B-cell CLL/lymphoma 7A
BOLA1 bolA family member 1
C19ORF40 chromosome 19 open reading frame 40
C19ORF54 chromosome 19 open reading frame 54
CARD8 caspase recruitment domain family, member 8
CASD1 CAS1 domain containing 1
CBR3 carbonyl reductase 3
CCDC51 coiled-coil domain containing 51
CDC7 cell division cycle 7
CLCF1 cardiotrophin-like cytokine factor 1
COA7 cytochrome c oxidase assembly factor 7 (putative)
COIL coilin
CTCF CCCTC-binding factor (zinc finger protein)
CUL1 cullin 1
DEPDC1 DEP domain containing 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DTWD1 DTW domain containing 1
FAM111A family with sequence similarity 111, member A
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
FST follistatin
GBX2 gastrulation brain homeobox 2
GTF2I general transcription factor IIi
HAS2 hyaluronan synthase 2
HMGA2 high mobility group AT-hook 2
HMGXB4 HMG box domain containing 4
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL7R interleukin 7 receptor
INHBB inhibin, beta B
IRF9 interferon regulatory factor 9
KAT6B K(lysine) acetyltransferase 6B
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KEAP1 kelch-like ECH-associated protein 1
LIF leukemia inhibitory factor
LMNB1 lamin B1
LPAR1 lysophosphatidic acid receptor 1
LRIF1 ligand dependent nuclear receptor interacting factor 1
LRRC41 leucine rich repeat containing 41
MEPCE methylphosphate capping enzyme
METTL4 methyltransferase like 4
METTL8 methyltransferase like 8
NHEJ1 nonhomologous end-joining factor 1
NMI N-myc (and STAT) interactor
NPM3 nucleophosmin/nucleoplasmin 3
NRIP1 nuclear receptor interacting protein 1
NSD1 nuclear receptor binding SET domain protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PAGR1 PAXIP1 associated glutamate-rich protein 1
PARP2 poly (ADP-ribose) polymerase 2
PEX14 peroxisomal biogenesis factor 14
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLK1 polo-like kinase 1
PPAP2B phosphatidic acid phosphatase type 2B
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PTPN9 protein tyrosine phosphatase, non-receptor type 9
QRICH1 glutamine-rich 1
RBM23 RNA binding motif protein 23
RIN2 Ras and Rab interactor 2
RNF146 ring finger protein 146
RPP38 ribonuclease P/MRP 38kDa subunit
SCAF8 SR-related CTD-associated factor 8
SCO2 SCO2 cytochrome c oxidase assembly protein
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETD1B SET domain containing 1B
SFMBT1 Scm-like with four mbt domains 1
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SMAGP small cell adhesion glycoprotein
SRSF4 serine/arginine-rich splicing factor 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SYNPO synaptopodin
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMC5 transmembrane channel-like 5
TMEM168 transmembrane protein 168
TRIB3 tribbles pseudokinase 3
TRPM2 transient receptor potential cation channel, subfamily M, member 2
USP21 ubiquitin specific peptidase 21
VEGFC vascular endothelial growth factor C
XBP1 X-box binding protein 1
ZBTB3 zinc finger and BTB domain containing 3
ZC3H4 zinc finger CCCH-type containing 4
ZC3H7A zinc finger CCCH-type containing 7A
ZCCHC10 zinc finger, CCHC domain containing 10
ZNF16 zinc finger protein 16
ZNF165 zinc finger protein 165
ZNF32 zinc finger protein 32
ZNF532 zinc finger protein 532