trichlormethiazide-4198 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the trichlormethiazide-4198 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ADAM22 ADAM metallopeptidase domain 22
AKAP5 A kinase (PRKA) anchor protein 5
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ARHGAP33 Rho GTPase activating protein 33
ASIC3 acid sensing (proton gated) ion channel 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BIN1 bridging integrator 1
BMP6 bone morphogenetic protein 6
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C11ORF63 chromosome 11 open reading frame 63
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD34 CD34 molecule
CDH19 cadherin 19, type 2
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLSTN3 calsyntenin 3
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CPB2 carboxypeptidase B2 (plasma)
CTC1 CTS telomere maintenance complex component 1
DMBT1 deleted in malignant brain tumors 1
DOHH deoxyhypusine hydroxylase/monooxygenase
DOK4 docking protein 4
DPY19L1P1 DPY19L1 pseudogene 1
DYM dymeclin
EDIL3 EGF-like repeats and discoidin I-like domains 3
FRS2 fibroblast growth factor receptor substrate 2
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GAS7 growth arrest-specific 7
GK2 glycerol kinase 2
GLP1R glucagon-like peptide 1 receptor
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
HBS1L HBS1-like translational GTPase
HOXC11 homeobox C11
IFT27 intraflagellar transport 27
IGL immunoglobulin lambda locus
IL18R1 interleukin 18 receptor 1
IL22 interleukin 22
INO80D INO80 complex subunit D
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IQCK IQ motif containing K
ITPKA inositol-trisphosphate 3-kinase A
KLF12 Kruppel-like factor 12
LMX1B LIM homeobox transcription factor 1, beta
LOX lysyl oxidase
MAGEA12 melanoma antigen family A12
MAPK11 mitogen-activated protein kinase 11
MIER2 mesoderm induction early response 1, family member 2
MMP3 matrix metallopeptidase 3
MON2 MON2 homolog (S. cerevisiae)
MTRF1L mitochondrial translational release factor 1-like
MYF5 myogenic factor 5
NDNF neuron-derived neurotrophic factor
NF1 neurofibromin 1
NOD1 nucleotide-binding oligomerization domain containing 1
NPAS3 neuronal PAS domain protein 3
NPC1 Niemann-Pick disease, type C1
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRP2 neuropilin 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OGFR opioid growth factor receptor
OR6A2 olfactory receptor, family 6, subfamily A, member 2
PGPEP1 pyroglutamyl-peptidase I
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLK3 polo-like kinase 3
PPP4R4 protein phosphatase 4, regulatory subunit 4
PQLC2 PQ loop repeat containing 2
PRKCA protein kinase C, alpha
PTCH1 patched 1
RAG1 recombination activating gene 1
RHEB Ras homolog enriched in brain
RHOBTB3 Rho-related BTB domain containing 3
RPL35A ribosomal protein L35a
RREB1 ras responsive element binding protein 1
SCARB1 scavenger receptor class B, member 1
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SH2D3A SH2 domain containing 3A
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SOS2 son of sevenless homolog 2 (Drosophila)
SPRR1B small proline-rich protein 1B
STRA6 stimulated by retinoic acid 6
SUGP1 SURP and G patch domain containing 1
TBRG4 transforming growth factor beta regulator 4
TCP11L1 t-complex 11, testis-specific-like 1
TLE4 transducin-like enhancer of split 4
TP73-AS1 TP73 antisense RNA 1
TRA2A transformer 2 alpha homolog (Drosophila)
TRIM29 tripartite motif containing 29
TSC22D2 TSC22 domain family, member 2
USP53 ubiquitin specific peptidase 53
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VPRBP Vpr (HIV-1) binding protein
WDR4 WD repeat domain 4
WSB1 WD repeat and SOCS box containing 1
YIPF4 Yip1 domain family, member 4
ZBTB20 zinc finger and BTB domain containing 20
ZNF639 zinc finger protein 639
ZNF688 zinc finger protein 688
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACE angiotensin I converting enzyme
ADAM2 ADAM metallopeptidase domain 2
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARHGAP22 Rho GTPase activating protein 22
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
BMP15 bone morphogenetic protein 15
C8A complement component 8, alpha polypeptide
CAMKMT calmodulin-lysine N-methyltransferase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CBX8 chromobox homolog 8
CCDC106 coiled-coil domain containing 106
CD68 CD68 molecule
CFAP45 cilia and flagella associated protein 45
CLDN1 claudin 1
CLTCL1 clathrin, heavy chain-like 1
CNN1 calponin 1, basic, smooth muscle
CORO1A coronin, actin binding protein, 1A
DNM3 dynamin 3
DSPP dentin sialophosphoprotein
EBF2 early B-cell factor 2
ERN2 endoplasmic reticulum to nucleus signaling 2
EXOC6B exocyst complex component 6B
FRMPD1 FERM and PDZ domain containing 1
GAS8 growth arrest-specific 8
GIF gastric intrinsic factor (vitamin B synthesis)
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRM4 glutamate receptor, metabotropic 4
GSTA3 glutathione S-transferase alpha 3
HIST1H2AI histone cluster 1, H2ai
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOOK1 hook microtubule-tethering protein 1
HOXA4 homeobox A4
HOXB9 homeobox B9
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFT140 intraflagellar transport 140
ISYNA1 inositol-3-phosphate synthase 1
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIAA1456 KIAA1456
KLF13 Kruppel-like factor 13
KPNA5 karyopherin alpha 5 (importin alpha 6)
LIME1 Lck interacting transmembrane adaptor 1
LRRC61 leucine rich repeat containing 61
LRRK1 leucine-rich repeat kinase 1
LY6D lymphocyte antigen 6 complex, locus D
MNT MAX network transcriptional repressor
MOCS3 molybdenum cofactor synthesis 3
MTA2 metastasis associated 1 family, member 2
MTCP1 mature T-cell proliferation 1
MTSS1L metastasis suppressor 1-like
MYO15A myosin XVA
MYO1D myosin ID
NDE1 nudE neurodevelopment protein 1
NINJ1 ninjurin 1
NXPH4 neurexophilin 4
ONECUT2 one cut homeobox 2
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSBP2 oxysterol binding protein 2
PACS1 phosphofurin acidic cluster sorting protein 1
PAIP2B poly(A) binding protein interacting protein 2B
PCDH12 protocadherin 12
PID1 phosphotyrosine interaction domain containing 1
PLBD1 phospholipase B domain containing 1
PPL periplakin
PRICKLE3 prickle homolog 3 (Drosophila)
RAPSN receptor-associated protein of the synapse
RNF39 ring finger protein 39
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RUSC2 RUN and SH3 domain containing 2
SCEL sciellin
SLC12A8 solute carrier family 12, member 8
SLC22A18 solute carrier family 22, member 18
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SNRPN small nuclear ribonucleoprotein polypeptide N
SOX21 SRY (sex determining region Y)-box 21
SPATA1 spermatogenesis associated 1
SPATA7 spermatogenesis associated 7
SPTBN2 spectrin, beta, non-erythrocytic 2
STEAP4 STEAP family member 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TINAGL1 tubulointerstitial nephritis antigen-like 1
TLN1 talin 1
TMEM120B transmembrane protein 120B
TMEM121 transmembrane protein 121
TMPRSS4 transmembrane protease, serine 4
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTLL7 tubulin tyrosine ligase-like family member 7
TUBA3D tubulin, alpha 3d
VGLL3 vestigial-like family member 3
XYLT2 xylosyltransferase II
ZFHX3 zinc finger homeobox 3
ZNF391 zinc finger protein 391
ZNF408 zinc finger protein 408
ZNF480 zinc finger protein 480
ZNF667 zinc finger protein 667