trichlormethiazide-3337 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the trichlormethiazide-3337 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
ALOX5 arachidonate 5-lipoxygenase
AQP3 aquaporin 3 (Gill blood group)
ASIC1 acid sensing (proton gated) ion channel 1
ATP11A ATPase, class VI, type 11A
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
C14ORF1 chromosome 14 open reading frame 1
C1QTNF1 C1q and tumor necrosis factor related protein 1
CLCA1 chloride channel accessory 1
CLSTN3 calsyntenin 3
CNTNAP2 contactin associated protein-like 2
DMPK dystrophia myotonica-protein kinase
EPHB2 EPH receptor B2
FKRP fukutin related protein
FLJ11710 uncharacterized protein FLJ11710
FST follistatin
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GK glycerol kinase
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPER1 G protein-coupled estrogen receptor 1
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GYPB glycophorin B (MNS blood group)
GZMK granzyme K (granzyme 3; tryptase II)
HCAR3 hydroxycarboxylic acid receptor 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB5 homeobox B5
ICOSLG inducible T-cell co-stimulator ligand
IGKV3-20 immunoglobulin kappa variable 3-20
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KIAA1109 KIAA1109
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LAMA2 laminin, alpha 2
LAMC2 laminin, gamma 2
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LONRF3 LON peptidase N-terminal domain and ring finger 3
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MX1 MX dynamin-like GTPase 1
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NCF4 neutrophil cytosolic factor 4, 40kDa
NDOR1 NADPH dependent diflavin oxidoreductase 1
NOL10 nucleolar protein 10
NOL12 nucleolar protein 12
NPC1 Niemann-Pick disease, type C1
NPR3 natriuretic peptide receptor 3
NR2F1 nuclear receptor subfamily 2, group F, member 1
NT5M 5',3'-nucleotidase, mitochondrial
NTS neurotensin
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
NUP188 nucleoporin 188kDa
PCDH1 protocadherin 1
PDK1 pyruvate dehydrogenase kinase, isozyme 1
POLM polymerase (DNA directed), mu
POU6F1 POU class 6 homeobox 1
PQLC2 PQ loop repeat containing 2
PRDX2 peroxiredoxin 2
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKCE protein kinase C, epsilon
PURA purine-rich element binding protein A
PVR poliovirus receptor
REC8 REC8 meiotic recombination protein
REM1 RAS (RAD and GEM)-like GTP-binding 1
RHBDL1 rhomboid, veinlet-like 1 (Drosophila)
RIF1 replication timing regulatory factor 1
RIMS3 regulating synaptic membrane exocytosis 3
SAG S-antigen; retina and pineal gland (arrestin)
SECTM1 secreted and transmembrane 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STMN1 stathmin 1
STRN striatin, calmodulin binding protein
STYK1 serine/threonine/tyrosine kinase 1
SUGP1 SURP and G patch domain containing 1
TCF20 transcription factor 20 (AR1)
TGFB2 transforming growth factor, beta 2
TLK1 tousled-like kinase 1
TMPRSS4 transmembrane protease, serine 4
TNK2 tyrosine kinase, non-receptor, 2
TNPO2 transportin 2
TP63 tumor protein p63
TRIM2 tripartite motif containing 2
TSPAN9 tetraspanin 9
TTLL4 tubulin tyrosine ligase-like family member 4
VSIG4 V-set and immunoglobulin domain containing 4
WAS Wiskott-Aldrich syndrome
WDFY3 WD repeat and FYVE domain containing 3
WNT2 wingless-type MMTV integration site family member 2
XAF1 XIAP associated factor 1
ZNF76 zinc finger protein 76
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ACTL8 actin-like 8
ADGRE5 adhesion G protein-coupled receptor E5
ASIC3 acid sensing (proton gated) ion channel 3
BAHD1 bromo adjacent homology domain containing 1
BMP4 bone morphogenetic protein 4
C19ORF73 chromosome 19 open reading frame 73
CAMK1 calcium/calmodulin-dependent protein kinase I
CCDC85C coiled-coil domain containing 85C
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CNTN1 contactin 1
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DBF4B DBF4 zinc finger B
DYSF dysferlin
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
ELOVL4 ELOVL fatty acid elongase 4
EPHA2 EPH receptor A2
ERCC6 excision repair cross-complementation group 6
ETNK2 ethanolamine kinase 2
FADS2 fatty acid desaturase 2
FAM155B family with sequence similarity 155, member B
FAM53B family with sequence similarity 53, member B
FGD1 FYVE, RhoGEF and PH domain containing 1
FLJ22184
FLT4 fms-related tyrosine kinase 4
GAMT guanidinoacetate N-methyltransferase
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GPR143 G protein-coupled receptor 143
GSTT1 glutathione S-transferase theta 1
HIST1H2AJ histone cluster 1, H2aj
HIST1H4D histone cluster 1, H4d
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IGFBP6 insulin-like growth factor binding protein 6
IQSEC2 IQ motif and Sec7 domain 2
KCTD17 potassium channel tetramerization domain containing 17
KIAA0754 KIAA0754
KIAA1107 KIAA1107
KLF3 Kruppel-like factor 3 (basic)
LAMP3 lysosomal-associated membrane protein 3
LHX1 LIM homeobox 1
LIME1 Lck interacting transmembrane adaptor 1
LPXN leupaxin
METTL2B methyltransferase like 2B
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MITF microphthalmia-associated transcription factor
MMP2 matrix metallopeptidase 2
MNX1 motor neuron and pancreas homeobox 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NXPH4 neurexophilin 4
PGBD5 piggyBac transposable element derived 5
PLCD1 phospholipase C, delta 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRODH proline dehydrogenase (oxidase) 1
RAB30 RAB30, member RAS oncogene family
RECQL4 RecQ protein-like 4
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF43 ring finger protein 43
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SGK1 serum/glucocorticoid regulated kinase 1
SKI SKI proto-oncogene
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLMO1 slowmo homolog 1 (Drosophila)
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPIDR scaffolding protein involved in DNA repair
SPTBN2 spectrin, beta, non-erythrocytic 2
SYBU syntabulin (syntaxin-interacting)
SYNC syncoilin, intermediate filament protein
TBC1D2 TBC1 domain family, member 2
TBX19 T-box 19
TCTN2 tectonic family member 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMEM104 transmembrane protein 104
TMEM212 transmembrane protein 212
TRAIP TRAF interacting protein
TRIM36 tripartite motif containing 36
TSGA10 testis specific, 10
UNC119 unc-119 homolog (C. elegans)
VAX2 ventral anterior homeobox 2
WDR33 WD repeat domain 33
WWC2 WW and C2 domain containing 2
XAB2 XPA binding protein 2
ZBTB22 zinc finger and BTB domain containing 22
ZBTB48 zinc finger and BTB domain containing 48
ZC3H3 zinc finger CCCH-type containing 3
ZFHX3 zinc finger homeobox 3
ZNF10 zinc finger protein 10
ZNF358 zinc finger protein 358
ZNF442 zinc finger protein 442
ZNF606 zinc finger protein 606
ZSCAN26 zinc finger and SCAN domain containing 26