trichlormethiazide-2998 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the trichlormethiazide-2998 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
ADAM12 ADAM metallopeptidase domain 12
AIM1L absent in melanoma 1-like
AKR1C1 aldo-keto reductase family 1, member C1
ANG angiogenin, ribonuclease, RNase A family, 5
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
AXIN1 axin 1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BGN biglycan
BMP1 bone morphogenetic protein 1
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHN2 chimerin 2
COL17A1 collagen, type XVII, alpha 1
COL1A2 collagen, type I, alpha 2
CSF1 colony stimulating factor 1 (macrophage)
CXXC4 CXXC finger protein 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDAH2 dimethylarginine dimethylaminohydrolase 2
DGCR8 DGCR8 microprocessor complex subunit
DGKE diacylglycerol kinase, epsilon 64kDa
EDN3 endothelin 3
EFNA3 ephrin-A3
EFNB3 ephrin-B3
EMP1 epithelial membrane protein 1
ETV2 ets variant 2
EVA1B eva-1 homolog B (C. elegans)
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FDPS farnesyl diphosphate synthase
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOXO4 forkhead box O4
GAST gastrin
GJA8 gap junction protein, alpha 8, 50kDa
GPX2 glutathione peroxidase 2
GRIK5 glutamate receptor, ionotropic, kainate 5
GSPT2 G1 to S phase transition 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HNF1B HNF1 homeobox B
HOXB3 homeobox B3
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IFI44 interferon-induced protein 44
INF2 inverted formin, FH2 and WH2 domain containing
IVL involucrin
JAG1 jagged 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3
KCTD2 potassium channel tetramerization domain containing 2
KDSR 3-ketodihydrosphingosine reductase
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0513 KIAA0513
LAMA2 laminin, alpha 2
LEF1 lymphoid enhancer-binding factor 1
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LIMD2 LIM domain containing 2
MMP11 matrix metallopeptidase 11
MVP major vault protein
MYO6 myosin VI
NKX2-1 NK2 homeobox 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRP1 neuropilin 1
PON3 paraoxonase 3
POU2F2 POU class 2 homeobox 2
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASL11B RAS-like, family 11, member B
RGS1 regulator of G-protein signaling 1
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RNF122 ring finger protein 122
RORC RAR-related orphan receptor C
RPS2P45 ribosomal protein S2 pseudogene 45
SARM1 sterile alpha and TIR motif containing 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SOD2 superoxide dismutase 2, mitochondrial
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SSBP2 single-stranded DNA binding protein 2
SSH3 slingshot protein phosphatase 3
SSTR4 somatostatin receptor 4
TEAD3 TEA domain family member 3
TEX40 testis expressed 40
TIMELESS timeless circadian clock
TMEM242 transmembrane protein 242
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TSC2 tuberous sclerosis 2
TSC22D4 TSC22 domain family, member 4
TUBG2 tubulin, gamma 2
ULBP1 UL16 binding protein 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZNF287 zinc finger protein 287
ZNF34 zinc finger protein 34
ZNF500 zinc finger protein 500

decreased expression

Symbol Name
ANKRD36 ankyrin repeat domain 36
ANXA3 annexin A3
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BTF3P11 basic transcription factor 3 pseudogene 11
BTF3P12 basic transcription factor 3 pseudogene 12
C14ORF159 chromosome 14 open reading frame 159
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CASP5 caspase 5, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC25 coiled-coil domain containing 25
CDHR2 cadherin-related family member 2
CDK6 cyclin-dependent kinase 6
CDR2L cerebellar degeneration-related protein 2-like
CEP97 centrosomal protein 97kDa
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CORT cortistatin
DENND5B DENN/MADD domain containing 5B
DNAAF2 dynein, axonemal, assembly factor 2
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DOLK dolichol kinase
EBF2 early B-cell factor 2
ECI2 enoyl-CoA delta isomerase 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FAM188A family with sequence similarity 188, member A
FEM1C fem-1 homolog c (C. elegans)
FES FES proto-oncogene, tyrosine kinase
FGF23 fibroblast growth factor 23
FKBPL FK506 binding protein like
FLT4 fms-related tyrosine kinase 4
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FPGT fucose-1-phosphate guanylyltransferase
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
HCK HCK proto-oncogene, Src family tyrosine kinase
HIST1H2AE histone cluster 1, H2ae
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BN histone cluster 1, H2bn
HOXB9 homeobox B9
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IL12B interleukin 12B
INPP1 inositol polyphosphate-1-phosphatase
KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIF23 kinesin family member 23
KPTN kaptin (actin binding protein)
KRT20 keratin 20, type I
LTC4S leukotriene C4 synthase
LY6D lymphocyte antigen 6 complex, locus D
LY6E lymphocyte antigen 6 complex, locus E
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MBIP MAP3K12 binding inhibitory protein 1
METTL16 methyltransferase like 16
MOCS3 molybdenum cofactor synthesis 3
MRPS18C mitochondrial ribosomal protein S18C
MTSS1L metastasis suppressor 1-like
MYL5 myosin, light chain 5, regulatory
NCKAP1L NCK-associated protein 1-like
NOL6 nucleolar protein 6 (RNA-associated)
NPIPB15 nuclear pore complex interacting protein family, member B15
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
PAQR4 progestin and adipoQ receptor family member IV
PBOV1 prostate and breast cancer overexpressed 1
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDZD7 PDZ domain containing 7
PIP prolactin-induced protein
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLTP phospholipid transfer protein
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRB3 proline-rich protein BstNI subfamily 3
RARS arginyl-tRNA synthetase
RBL1 retinoblastoma-like 1
RCAN3 RCAN family member 3
SCRN3 secernin 3
SH3GL1 SH3-domain GRB2-like 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMR3A submaxillary gland androgen regulated protein 3A
SNX16 sorting nexin 16
SPATA2L spermatogenesis associated 2-like
SRD5A3 steroid 5 alpha-reductase 3
TCTN1 tectonic family member 1
TMEM209 transmembrane protein 209
TMEM212 transmembrane protein 212
TPBG trophoblast glycoprotein
TRIM5 tripartite motif containing 5
TTC26 tetratricopeptide repeat domain 26
UEVLD UEV and lactate/malate dehyrogenase domains
ZBTB6 zinc finger and BTB domain containing 6
ZNF322P1 zinc finger protein 322 pseudogene 1
ZNF668 zinc finger protein 668
ZSCAN31 zinc finger and SCAN domain containing 31