tretinoin-991 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the tretinoin-991 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM19 ADAM metallopeptidase domain 19
AJAP1 adherens junctions associated protein 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AOX1 aldehyde oxidase 1
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATN1 atrophin 1
BDKRB2 bradykinin receptor B2
BTG2 BTG family, member 2
C1ORF112 chromosome 1 open reading frame 112
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCNO cyclin O
CDH5 cadherin 5, type 2 (vascular endothelium)
CHML choroideremia-like (Rab escort protein 2)
CLCN5 chloride channel, voltage-sensitive 5
CLMN calmin (calponin-like, transmembrane)
CLUAP1 clusterin associated protein 1
COPZ2 coatomer protein complex, subunit zeta 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSTA cystatin A (stefin A)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DAPK2 death-associated protein kinase 2
DEGS1 delta(4)-desaturase, sphingolipid 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMID1 EMI domain containing 1
EPAS1 endothelial PAS domain protein 1
EPB41L1 erythrocyte membrane protein band 4.1-like 1
FAM105A family with sequence similarity 105, member A
FAM174B family with sequence similarity 174, member B
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
HCAR3 hydroxycarboxylic acid receptor 3
HDAC7 histone deacetylase 7
HOXA1 homeobox A1
HOXA4 homeobox A4
HOXA5 homeobox A5
HOXB2 homeobox B2
HOXC13 homeobox C13
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IRF1 interferon regulatory factor 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KAT6B K(lysine) acetyltransferase 6B
KIAA0125 KIAA0125
KLK6 kallikrein-related peptidase 6
KMT2A lysine (K)-specific methyltransferase 2A
KRT13 keratin 13, type I
LIMCH1 LIM and calponin homology domains 1
MAG myelin associated glycoprotein
MEIS2 Meis homeobox 2
NAV2 neuron navigator 2
NR5A2 nuclear receptor subfamily 5, group A, member 2
PBX1 pre-B-cell leukemia homeobox 1
PCDH12 protocadherin 12
PDE4DIP phosphodiesterase 4D interacting protein
PDE8B phosphodiesterase 8B
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G10 phospholipase A2, group X
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKCD protein kinase C, delta
PTGES prostaglandin E synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB3A RAB3A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RGS16 regulator of G-protein signaling 16
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
SCLY selenocysteine lyase
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELL selectin L
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SIK1 salt-inducible kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TLE4 transducin-like enhancer of split 4
TMEM144 transmembrane protein 144
TMPRSS2 transmembrane protease, serine 2
TMPRSS4 transmembrane protease, serine 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNK1 tyrosine kinase, non-receptor, 1
TPMT thiopurine S-methyltransferase
TRIM2 tripartite motif containing 2
TRIM31 tripartite motif containing 31
TSC22D3 TSC22 domain family, member 3
VGF VGF nerve growth factor inducible
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF227 zinc finger protein 227
ZNF614 zinc finger protein 614
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADAM15 ADAM metallopeptidase domain 15
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4A ADP-ribosylation factor-like 4A
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BMP4 bone morphogenetic protein 4
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C3ORF52 chromosome 3 open reading frame 52
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CAMTA2 calmodulin binding transcription activator 2
CCDC88C coiled-coil domain containing 88C
CD302 CD302 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPT centromere protein T
CISH cytokine inducible SH2-containing protein
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR3 early growth response 3
EVL Enah/Vasp-like
FOSL1 FOS-like antigen 1
FZD4 frizzled class receptor 4
GLB1L2 galactosidase, beta 1-like 2
GNL1 guanine nucleotide binding protein-like 1
GPATCH3 G patch domain containing 3
GPRC5C G protein-coupled receptor, class C, group 5, member C
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGSF3 immunoglobulin superfamily, member 3
IL4R interleukin 4 receptor
IRF2 interferon regulatory factor 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KLF11 Kruppel-like factor 11
LRP3 low density lipoprotein receptor-related protein 3
LRRC49 leucine rich repeat containing 49
LYPD3 LY6/PLAUR domain containing 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAST3 microtubule associated serine/threonine kinase 3
MDM4 MDM4, p53 regulator
MISP mitotic spindle positioning
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NARFL nuclear prelamin A recognition factor-like
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NMU neuromedin U
NPY5R neuropeptide Y receptor Y5
PAQR4 progestin and adipoQ receptor family member IV
PCNXL4 pecanex-like 4 (Drosophila)
PGP phosphoglycolate phosphatase
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLA2G15 phospholipase A2, group XV
PMEPA1 prostate transmembrane protein, androgen induced 1
PMP22 peripheral myelin protein 22
POMT1 protein-O-mannosyltransferase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROCR protein C receptor, endothelial
PSKH1 protein serine kinase H1
PTPRG protein tyrosine phosphatase, receptor type, G
RAB32 RAB32, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
RECQL4 RecQ protein-like 4
RHOB ras homolog family member B
RPH3AL rabphilin 3A-like (without C2 domains)
S100A4 S100 calcium binding protein A4
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A10 solute carrier family 38, member 10
SLC41A3 solute carrier family 41, member 3
SMA4 glucuronidase, beta pseudogene
SMAD7 SMAD family member 7
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMTN smoothelin
SPHK1 sphingosine kinase 1
SPIDR scaffolding protein involved in DNA repair
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STARD5 StAR-related lipid transfer (START) domain containing 5
STBD1 starch binding domain 1
SYCP2 synaptonemal complex protein 2
SYT17 synaptotagmin XVII
TM7SF3 transmembrane 7 superfamily member 3
TPST2 tyrosylprotein sulfotransferase 2
TRAF5 TNF receptor-associated factor 5
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TULP4 tubby like protein 4
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
ULBP2 UL16 binding protein 2
USP36 ubiquitin specific peptidase 36
USP6 ubiquitin specific peptidase 6
XK X-linked Kx blood group
ZC3H12A zinc finger CCCH-type containing 12A
ZFP30 ZFP30 zinc finger protein
ZNF280D zinc finger protein 280D