tretinoin-447 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the tretinoin-447 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ACAN aggrecan
ADA adenosine deaminase
AGTR2 angiotensin II receptor, type 2
AMPD3 adenosine monophosphate deaminase 3
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APOC1 apolipoprotein C-I
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
AVPR1B arginine vasopressin receptor 1B
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
C21ORF2 chromosome 21 open reading frame 2
CA5B carbonic anhydrase VB, mitochondrial
CA7 carbonic anhydrase VII
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAPN5 calpain 5
CCDC71 coiled-coil domain containing 71
CLDN17 claudin 17
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
COL1A2 collagen, type I, alpha 2
COL5A1 collagen, type V, alpha 1
CORO1B coronin, actin binding protein, 1B
CORT cortistatin
CTSE cathepsin E
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DOK3 docking protein 3
DPP6 dipeptidyl-peptidase 6
DRG2 developmentally regulated GTP binding protein 2
EGFL7 EGF-like-domain, multiple 7
EGLN3 egl-9 family hypoxia-inducible factor 3
EPX eosinophil peroxidase
ERCC5 excision repair cross-complementation group 5
EXOC7 exocyst complex component 7
FUS FUS RNA binding protein
GALR3 galanin receptor 3
GPM6B glycoprotein M6B
GRIP2 glutamate receptor interacting protein 2
GRK6 G protein-coupled receptor kinase 6
GSK3A glycogen synthase kinase 3 alpha
H2AFY2 H2A histone family, member Y2
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IFFO1 intermediate filament family orphan 1
INO80B INO80 complex subunit B
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF15 Kruppel-like factor 15
LENEP lens epithelial protein
LRRC1 leucine rich repeat containing 1
MAST2 microtubule associated serine/threonine kinase 2
MAU2 MAU2 sister chromatid cohesion factor
MCM5 minichromosome maintenance complex component 5
MOGAT2 monoacylglycerol O-acyltransferase 2
MT4 metallothionein 4
MTMR8 myotubularin related protein 8
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCOR2 nuclear receptor corepressor 2
NCR2 natural cytotoxicity triggering receptor 2
NIPAL2 NIPA-like domain containing 2
NIPAL3 NIPA-like domain containing 3
NMT1 N-myristoyltransferase 1
NTSR1 neurotensin receptor 1 (high affinity)
NXPH4 neurexophilin 4
OGFRL1 opioid growth factor receptor-like 1
OLFML1 olfactomedin-like 1
PBX2 pre-B-cell leukemia homeobox 2
PHC1 polyhomeotic homolog 1 (Drosophila)
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POTEKP POTE ankyrin domain family, member K, pseudogene
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRB1 proline-rich protein BstNI subfamily 1
PRLH prolactin releasing hormone
PROL1 proline rich, lacrimal 1
PRRC2B proline-rich coiled-coil 2B
PRSS8 protease, serine, 8
PSG11 pregnancy specific beta-1-glycoprotein 11
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
S1PR4 sphingosine-1-phosphate receptor 4
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SF3A2 splicing factor 3a, subunit 2, 66kDa
SHCBP1L SHC SH2-domain binding protein 1-like
SLA Src-like-adaptor
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SNPH syntaphilin
SPN sialophorin
STAB2 stabilin 2
TMEM53 transmembrane protein 53
TNK1 tyrosine kinase, non-receptor, 1
TP73-AS1 TP73 antisense RNA 1
UTRN utrophin
WDR48 WD repeat domain 48
ZFYVE9 zinc finger, FYVE domain containing 9

decreased expression

Symbol Name
ADM2 adrenomedullin 2
AK5 adenylate kinase 5
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ATF7IP2 activating transcription factor 7 interacting protein 2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C19ORF57 chromosome 19 open reading frame 57
C2CD5 C2 calcium-dependent domain containing 5
C2ORF44 chromosome 2 open reading frame 44
C9ORF3 chromosome 9 open reading frame 3
CCDC85C coiled-coil domain containing 85C
CD79A CD79a molecule, immunoglobulin-associated alpha
CDC73 cell division cycle 73
CHN1 chimerin 1
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLDN11 claudin 11
CLDN9 claudin 9
CLK3 CDC-like kinase 3
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COQ3 coenzyme Q3 methyltransferase
CPOX coproporphyrinogen oxidase
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DBF4 DBF4 zinc finger
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DNAAF2 dynein, axonemal, assembly factor 2
DYSF dysferlin
ERMP1 endoplasmic reticulum metallopeptidase 1
EXOSC9 exosome component 9
FAM153A family with sequence similarity 153, member A
FGL1 fibrinogen-like 1
FOXD1 forkhead box D1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GREB1L growth regulation by estrogen in breast cancer-like
GSTT1 glutathione S-transferase theta 1
HACD1 3-hydroxyacyl-CoA dehydratase 1
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IRF2 interferon regulatory factor 2
JAM3 junctional adhesion molecule 3
KIAA0513 KIAA0513
KIFAP3 kinesin-associated protein 3
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
LIN7B lin-7 homolog B (C. elegans)
LUZP4 leucine zipper protein 4
MAST3 microtubule associated serine/threonine kinase 3
MGMT O-6-methylguanine-DNA methyltransferase
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NFE2L2 nuclear factor, erythroid 2-like 2
NQO2 NAD(P)H dehydrogenase, quinone 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
ORC3 origin recognition complex, subunit 3
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PCSK7 proprotein convertase subtilisin/kexin type 7
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PFAS phosphoribosylformylglycinamidine synthase
PHEX phosphate regulating endopeptidase homolog, X-linked
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLM polymerase (DNA directed), mu
RAB33B RAB33B, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RAD54L RAD54-like (S. cerevisiae)
RAP1GAP2 RAP1 GTPase activating protein 2
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RMI1 RecQ mediated genome instability 1
RNF141 ring finger protein 141
RNF220 ring finger protein 220
RNF39 ring finger protein 39
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SHPK sedoheptulokinase
SIPA1 signal-induced proliferation-associated 1
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC17A4 solute carrier family 17, member 4
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SPDL1 spindle apparatus coiled-coil protein 1
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYT2 synaptotagmin II
TBC1D16 TBC1 domain family, member 16
TBPL1 TBP-like 1
TGFBR1 transforming growth factor, beta receptor 1
THOC1 THO complex 1
TJP2 tight junction protein 2
TMEM184C transmembrane protein 184C
TOM1L1 target of myb1 (chicken)-like 1
TRIM5 tripartite motif containing 5
TTC26 tetratricopeptide repeat domain 26
TTC27 tetratricopeptide repeat domain 27
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZFP30 ZFP30 zinc finger protein
ZNF329 zinc finger protein 329
ZNF394 zinc finger protein 394
ZNF408 zinc finger protein 408