trazodone-7452 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trazodone-7452 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
AK2 adenylate kinase 2
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
APOE apolipoprotein E
ATN1 atrophin 1
BFSP1 beaded filament structural protein 1, filensin
C10ORF95 chromosome 10 open reading frame 95
C5AR2 complement component 5a receptor 2
CCDC134 coiled-coil domain containing 134
CCDC93 coiled-coil domain containing 93
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD80 CD80 molecule
CDC14A cell division cycle 14A
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDK13 cyclin-dependent kinase 13
CLTA clathrin, light chain A
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DIAPH2-AS1 DIAPH2 antisense RNA 1
DLK2 delta-like 2 homolog (Drosophila)
DOK2 docking protein 2, 56kDa
ELL2 elongation factor, RNA polymerase II, 2
EPHB2 EPH receptor B2
FGL2 fibrinogen-like 2
FLJ11292
GM2A GM2 ganglioside activator
GPATCH4 G patch domain containing 4
GPC1 glypican 1
GSDMB gasdermin B
HAO2 hydroxyacid oxidase 2 (long chain)
HDLBP high density lipoprotein binding protein
IFT27 intraflagellar transport 27
IRF4 interferon regulatory factor 4
IRS2 insulin receptor substrate 2
JAK3 Janus kinase 3
JAM3 junctional adhesion molecule 3
KAT6A K(lysine) acetyltransferase 6A
KDM6A lysine (K)-specific demethylase 6A
KDM8 lysine (K)-specific demethylase 8
KIAA0930 KIAA0930
KIF1A kinesin family member 1A
KLHL20 kelch-like family member 20
LAX1 lymphocyte transmembrane adaptor 1
LENEP lens epithelial protein
LIG3 ligase III, DNA, ATP-dependent
MAP2 microtubule-associated protein 2
MAPK11 mitogen-activated protein kinase 11
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MED14 mediator complex subunit 14
MFSD7 major facilitator superfamily domain containing 7
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MMP11 matrix metallopeptidase 11
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MVP major vault protein
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NCAPH2 non-SMC condensin II complex, subunit H2
NCLN nicalin
NR6A1 nuclear receptor subfamily 6, group A, member 1
NRF1 nuclear respiratory factor 1
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
PAQR6 progestin and adipoQ receptor family member VI
PHC1 polyhomeotic homolog 1 (Drosophila)
PILRA paired immunoglobin-like type 2 receptor alpha
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLAC4 placenta-specific 4
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRPH peripherin
RARA retinoic acid receptor, alpha
RCAN3 RCAN family member 3
RERE arginine-glutamic acid dipeptide (RE) repeats
RGS12 regulator of G-protein signaling 12
RPL7 ribosomal protein L7
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RTEL1 regulator of telomere elongation helicase 1
SAA4 serum amyloid A4, constitutive
SCAPER S-phase cyclin A-associated protein in the ER
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SGK2 serum/glucocorticoid regulated kinase 2
SLC26A1 solute carrier family 26 (anion exchanger), member 1
SMAD4 SMAD family member 4
SOX10 SRY (sex determining region Y)-box 10
SP100 SP100 nuclear antigen
SPTAN1 spectrin, alpha, non-erythrocytic 1
ST5 suppression of tumorigenicity 5
STAB2 stabilin 2
STXBP6 syntaxin binding protein 6 (amisyn)
TAT tyrosine aminotransferase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLE4 transducin-like enhancer of split 4
TMEM19 transmembrane protein 19
TMOD1 tropomodulin 1
TNS2 tensin 2
TRAK1 trafficking protein, kinesin binding 1
TRH thyrotropin-releasing hormone
USP34 ubiquitin specific peptidase 34
WDR78 WD repeat domain 78
WSCD1 WSC domain containing 1

decreased expression

Symbol Name
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ALAD aminolevulinate dehydratase
AMOTL2 angiomotin like 2
ASL argininosuccinate lyase
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAD3A ATPase family, AAA domain containing 3A
ATG2B autophagy related 2B
BBC3 BCL2 binding component 3
BPGM 2,3-bisphosphoglycerate mutase
BPHL biphenyl hydrolase-like (serine hydrolase)
C16ORF59 chromosome 16 open reading frame 59
C19ORF40 chromosome 19 open reading frame 40
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCDC25 coiled-coil domain containing 25
CENPT centromere protein T
CEP72 centrosomal protein 72kDa
COPS7B COP9 signalosome subunit 7B
CRYZL1 crystallin, zeta (quinone reductase)-like 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DENND1A DENN/MADD domain containing 1A
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DSE dermatan sulfate epimerase
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EPHA2 EPH receptor A2
FAM111A family with sequence similarity 111, member A
FAM172A family with sequence similarity 172, member A
FCHSD2 FCH and double SH3 domains 2
FIP1L1 factor interacting with PAPOLA and CPSF1
FSD1 fibronectin type III and SPRY domain containing 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GLB1L2 galactosidase, beta 1-like 2
GPRC5C G protein-coupled receptor, class C, group 5, member C
GSTT1 glutathione S-transferase theta 1
GTPBP2 GTP binding protein 2
HAUS6 HAUS augmin-like complex, subunit 6
HIST1H2AG histone cluster 1, H2ag
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IFT81 intraflagellar transport 81
IKZF5 IKAROS family zinc finger 5 (Pegasus)
ILKAP integrin-linked kinase-associated serine/threonine phosphatase
JMJD1C jumonji domain containing 1C
KLF11 Kruppel-like factor 11
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIG4 ligase IV, DNA, ATP-dependent
LRRC20 leucine rich repeat containing 20
LY6G5C lymphocyte antigen 6 complex, locus G5C
MANBA mannosidase, beta A, lysosomal
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPKBP1 mitogen-activated protein kinase binding protein 1
METTL8 methyltransferase like 8
MGC12488
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MT1HL1 metallothionein 1H-like 1
MTMR11 myotubularin related protein 11
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NHEJ1 nonhomologous end-joining factor 1
NHLRC2 NHL repeat containing 2
NLK nemo-like kinase
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NR1H3 nuclear receptor subfamily 1, group H, member 3
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PANK4 pantothenate kinase 4
PLD3 phospholipase D family, member 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRODH proline dehydrogenase (oxidase) 1
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PTBP2 polypyrimidine tract binding protein 2
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB33B RAB33B, member RAS oncogene family
RASA2 RAS p21 protein activator 2
RPL13P5 ribosomal protein L13 pseudogene 5
SARS2 seryl-tRNA synthetase 2, mitochondrial
SDF2 stromal cell-derived factor 2
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC31A2 solute carrier family 31 (copper transporter), member 2
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNRPC small nuclear ribonucleoprotein polypeptide C
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STARD13 StAR-related lipid transfer (START) domain containing 13
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TPCN1 two pore segment channel 1
TRAF2 TNF receptor-associated factor 2
TRIM45 tripartite motif containing 45
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTC17 tetratricopeptide repeat domain 17
TUBA3C tubulin, alpha 3c
TWF2 twinfilin actin binding protein 2
USB1 U6 snRNA biogenesis 1
VASP vasodilator-stimulated phosphoprotein
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WFS1 Wolfram syndrome 1 (wolframin)
WWC2 WW and C2 domain containing 2
ZFYVE16 zinc finger, FYVE domain containing 16
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF14 zinc finger protein 14
ZNF23 zinc finger protein 23