trazodone-7410 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the trazodone-7410 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGMAT agmatine ureohydrolase (agmatinase)
AHCYL2 adenosylhomocysteinase-like 2
AIM1L absent in melanoma 1-like
AJAP1 adherens junctions associated protein 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
APLP1 amyloid beta (A4) precursor-like protein 1
AR androgen receptor
ATP11A ATPase, class VI, type 11A
C9ORF9 chromosome 9 open reading frame 9
CD83 CD83 molecule
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CFLAR CASP8 and FADD-like apoptosis regulator
CLCN2 chloride channel, voltage-sensitive 2
CLDN17 claudin 17
CLMN calmin (calponin-like, transmembrane)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DGCR6L DiGeorge syndrome critical region gene 6-like
DHRS3 dehydrogenase/reductase (SDR family) member 3
DLG5 discs, large homolog 5 (Drosophila)
DLK2 delta-like 2 homolog (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DRD2 dopamine receptor D2
DST dystonin
DSTYK dual serine/threonine and tyrosine protein kinase
EIF5 eukaryotic translation initiation factor 5
EPAS1 endothelial PAS domain protein 1
EPHA3 EPH receptor A3
ERCC2 excision repair cross-complementation group 2
FAM120C family with sequence similarity 120C
FAM65A family with sequence similarity 65, member A
FLT4 fms-related tyrosine kinase 4
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GOSR2 golgi SNAP receptor complex member 2
GSTP1 glutathione S-transferase pi 1
HFE hemochromatosis
HMG20B high mobility group 20B
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGKV1D-13 immunoglobulin kappa variable 1D-13
IL16 interleukin 16
IL4R interleukin 4 receptor
ING4 inhibitor of growth family, member 4
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IRF1 interferon regulatory factor 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRS2 insulin receptor substrate 2
KAZN kazrin, periplakin interacting protein
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0125 KIAA0125
LAMP1 lysosomal-associated membrane protein 1
LIMK1 LIM domain kinase 1
LPIN1 lipin 1
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAST3 microtubule associated serine/threonine kinase 3
MID1 midline 1
NCAPH2 non-SMC condensin II complex, subunit H2
NF2 neurofibromin 2 (merlin)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRX1 NLR family member X1
NOV nephroblastoma overexpressed
PAX5 paired box 5
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
POFUT1 protein O-fucosyltransferase 1
PPAP2B phosphatidic acid phosphatase type 2B
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PTGES prostaglandin E synthase
PXDC1 PX domain containing 1
RAP1GAP RAP1 GTPase activating protein
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUFY3 RUN and FYVE domain containing 3
S100A8 S100 calcium binding protein A8
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC12A8 solute carrier family 12, member 8
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNAI2 snail family zinc finger 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPHK2 sphingosine kinase 2
SPRR3 small proline-rich protein 3
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STAB2 stabilin 2
STK4 serine/threonine kinase 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGM2 transglutaminase 2
TM4SF5 transmembrane 4 L six family member 5
TOP3A topoisomerase (DNA) III alpha
TP53I11 tumor protein p53 inducible protein 11
TRIM62 tripartite motif containing 62
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TTC38 tetratricopeptide repeat domain 38
ZNF419 zinc finger protein 419
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
ACYP2 acylphosphatase 2, muscle type
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
AMOTL2 angiomotin like 2
AP3M2 adaptor-related protein complex 3, mu 2 subunit
ATP11B ATPase, class VI, type 11B
BTF3P12 basic transcription factor 3 pseudogene 12
C10ORF88 chromosome 10 open reading frame 88
C17ORF70 chromosome 17 open reading frame 70
C17ORF75 chromosome 17 open reading frame 75
C19ORF40 chromosome 19 open reading frame 40
C21ORF91 chromosome 21 open reading frame 91
CAMKMT calmodulin-lysine N-methyltransferase
CARD8 caspase recruitment domain family, member 8
CASP3 caspase 3, apoptosis-related cysteine peptidase
CENPC centromere protein C
CLDN9 claudin 9
COBL cordon-bleu WH2 repeat protein
CTSK cathepsin K
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DDIT3 DNA-damage-inducible transcript 3
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DEAF1 DEAF1 transcription factor
DUSP22 dual specificity phosphatase 22
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
ERCC5 excision repair cross-complementation group 5
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM155B family with sequence similarity 155, member B
FAM193A family with sequence similarity 193, member A
FAM86C1 family with sequence similarity 86, member C1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD4 frizzled class receptor 4
GAB2 GRB2-associated binding protein 2
GPRASP1 G protein-coupled receptor associated sorting protein 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
H2AFY2 H2A histone family, member Y2
HIST1H1D histone cluster 1, H1d
HOXC10 homeobox C10
HPS6 Hermansky-Pudlak syndrome 6
IP6K2 inositol hexakisphosphate kinase 2
KCTD15 potassium channel tetramerization domain containing 15
KRT86 keratin 86, type II
LINC00115 long intergenic non-protein coding RNA 115
LOC642236 FSHD region gene 1 pseudogene
MBTD1 mbt domain containing 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
METTL16 methyltransferase like 16
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NES nestin
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
NUP62CL nucleoporin 62kDa C-terminal like
ORAI3 ORAI calcium release-activated calcium modulator 3
OXTR oxytocin receptor
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae)
PDGFRL platelet-derived growth factor receptor-like
PEX26 peroxisomal biogenesis factor 26
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRAF2 PRA1 domain family, member 2
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB4B RAB4B, member RAS oncogene family
RGS17 regulator of G-protein signaling 17
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIPK4 receptor-interacting serine-threonine kinase 4
RPL23AP32 ribosomal protein L23a pseudogene 32
RPUSD2 RNA pseudouridylate synthase domain containing 2
SERTAD3 SERTA domain containing 3
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SNHG20 small nucleolar RNA host gene 20
SOBP sine oculis binding protein homolog (Drosophila)
TBC1D12 TBC1 domain family, member 12
TCTN1 tectonic family member 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TM7SF3 transmembrane 7 superfamily member 3
TRABD TraB domain containing
TRIM5 tripartite motif containing 5
TULP4 tubby like protein 4
TWF2 twinfilin actin binding protein 2
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZBTB3 zinc finger and BTB domain containing 3
ZC3H12A zinc finger CCCH-type containing 12A
ZNF219 zinc finger protein 219
ZNF248 zinc finger protein 248
ZNF253 zinc finger protein 253
ZNF322P1 zinc finger protein 322 pseudogene 1
ZNF365 zinc finger protein 365
ZNF468 zinc finger protein 468
ZNF816 zinc finger protein 816
ZNHIT2 zinc finger, HIT-type containing 2