trazodone-2379 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the trazodone-2379 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ADAM28 ADAM metallopeptidase domain 28
ADCY1 adenylate cyclase 1 (brain)
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AKAP4 A kinase (PRKA) anchor protein 4
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARNT aryl hydrocarbon receptor nuclear translocator
ARRB2 arrestin, beta 2
ASPH aspartate beta-hydroxylase
AXL AXL receptor tyrosine kinase
C16ORF70 chromosome 16 open reading frame 70
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CAPN2 calpain 2, (m/II) large subunit
CAT catalase
CCDC64 coiled-coil domain containing 64
CCL22 chemokine (C-C motif) ligand 22
CCL23 chemokine (C-C motif) ligand 23
CCSER2 coiled-coil serine-rich protein 2
CD300C CD300c molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD84 CD84 molecule
CDK3 cyclin-dependent kinase 3
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CGA glycoprotein hormones, alpha polypeptide
CRABP2 cellular retinoic acid binding protein 2
CRAT carnitine O-acetyltransferase
CSHL1 chorionic somatomammotropin hormone-like 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCAF15 DDB1 and CUL4 associated factor 15
DGCR8 DGCR8 microprocessor complex subunit
DLC1 DLC1 Rho GTPase activating protein
DOCK6 dedicator of cytokinesis 6
DSTYK dual serine/threonine and tyrosine protein kinase
DTNA dystrobrevin, alpha
DZANK1 double zinc ribbon and ankyrin repeat domains 1
DZIP3 DAZ interacting zinc finger protein 3
EMP2 epithelial membrane protein 2
ESR1 estrogen receptor 1
ETV7 ets variant 7
FAM127B family with sequence similarity 127, member B
FAM214B family with sequence similarity 214, member B
FAM63B family with sequence similarity 63, member B
FERMT2 fermitin family member 2
GATA2 GATA binding protein 2
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GPR153 G protein-coupled receptor 153
GSPT2 G1 to S phase transition 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HOXB5 homeobox B5
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IDI2-AS1 IDI2 antisense RNA 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ISYNA1 inositol-3-phosphate synthase 1
KIF13B kinesin family member 13B
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KLK7 kallikrein-related peptidase 7
LIMS2 LIM and senescent cell antigen-like domains 2
LINC00260 long intergenic non-protein coding RNA 260
LPAR2 lysophosphatidic acid receptor 2
LY96 lymphocyte antigen 96
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MEF2C myocyte enhancer factor 2C
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAZ3 ornithine decarboxylase antizyme 3
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PDE4DIP phosphodiesterase 4D interacting protein
PDE8B phosphodiesterase 8B
PDLIM4 PDZ and LIM domain 4
PHF8 PHD finger protein 8
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCG1 phospholipase C, gamma 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RBPMS RNA binding protein with multiple splicing
RHBDD3 rhomboid domain containing 3
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUNDC3A RUN domain containing 3A
SCARF1 scavenger receptor class F, member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SIK2 salt-inducible kinase 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMAD3 SMAD family member 3
SOX10 SRY (sex determining region Y)-box 10
SPDEF SAM pointed domain containing ETS transcription factor
STBD1 starch binding domain 1
TEF thyrotrophic embryonic factor
USP2 ubiquitin specific peptidase 2
WNT16 wingless-type MMTV integration site family, member 16
WSCD1 WSC domain containing 1
XDH xanthine dehydrogenase
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF205 zinc finger protein 205

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACP6 acid phosphatase 6, lysophosphatidic
ADAM15 ADAM metallopeptidase domain 15
ADAP2 ArfGAP with dual PH domains 2
AGO4 argonaute RISC catalytic component 4
ALS2CL ALS2 C-terminal like
APH1B APH1B gamma secretase subunit
AVPI1 arginine vasopressin-induced 1
BATF basic leucine zipper transcription factor, ATF-like
C14ORF93 chromosome 14 open reading frame 93
C1ORF95 chromosome 1 open reading frame 95
C22ORF46 chromosome 22 open reading frame 46
CA11 carbonic anhydrase XI
CARD9 caspase recruitment domain family, member 9
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC71 coiled-coil domain containing 71
CCDC94 coiled-coil domain containing 94
CCNL2 cyclin L2
CDA cytidine deaminase
CECR1 cat eye syndrome chromosome region, candidate 1
CNPY4 canopy FGF signaling regulator 4
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CPNE1 copine I
CPNE7 copine VII
DDN dendrin
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ELAC1 elaC ribonuclease Z 1
EML4 echinoderm microtubule associated protein like 4
ERCC6L excision repair cross-complementation group 6-like
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1L ERO1-like (S. cerevisiae)
FAM102A family with sequence similarity 102, member A
FAM163A family with sequence similarity 163, member A
FAM204A family with sequence similarity 204, member A
FBRS fibrosin
FGL1 fibrinogen-like 1
GEMIN8 gem (nuclear organelle) associated protein 8
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GSTCD glutathione S-transferase, C-terminal domain containing
GSTZ1 glutathione S-transferase zeta 1
GTF2I general transcription factor IIi
HAMP hepcidin antimicrobial peptide
HIST1H2BE histone cluster 1, H2be
HIST3H2A histone cluster 3, H2a
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOOK2 hook microtubule-tethering protein 2
HOPX HOP homeobox
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
LACTB2 lactamase, beta 2
LINS lines homolog (Drosophila)
LRP3 low density lipoprotein receptor-related protein 3
LRRC20 leucine rich repeat containing 20
LTBP2 latent transforming growth factor beta binding protein 2
MCMBP minichromosome maintenance complex binding protein
MTA2 metastasis associated 1 family, member 2
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NOD1 nucleotide-binding oligomerization domain containing 1
NOL12 nucleolar protein 12
NTSR1 neurotensin receptor 1 (high affinity)
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
PADI1 peptidyl arginine deiminase, type I
PANX1 pannexin 1
PBX3 pre-B-cell leukemia homeobox 3
PHACTR4 phosphatase and actin regulator 4
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PODXL2 podocalyxin-like 2
PROSER1 proline and serine rich 1
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RABL3 RAB, member of RAS oncogene family-like 3
RBM42 RNA binding motif protein 42
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPAP1 RNA polymerase II associated protein 1
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SCGB2A2 secretoglobin, family 2A, member 2
SLC22A14 solute carrier family 22, member 14
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNRPN small nuclear ribonucleoprotein polypeptide N
STXBP1 syntaxin binding protein 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TKFC triokinase/FMN cyclase
TMC7 transmembrane channel-like 7
TRAF2 TNF receptor-associated factor 2
TSPAN5 tetraspanin 5
UNC93B1 unc-93 homolog B1 (C. elegans)
WFDC2 WAP four-disulfide core domain 2
YY2 YY2 transcription factor
ZMYM3 zinc finger, MYM-type 3
ZNF551 zinc finger protein 551
ZNF665 zinc finger protein 665
ZNF747 zinc finger protein 747