tranexamic acid-6238 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the tranexamic acid-6238 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADAM17 ADAM metallopeptidase domain 17
ADGRE5 adhesion G protein-coupled receptor E5
AFF4 AF4/FMR2 family, member 4
AKAP9 A kinase (PRKA) anchor protein 9
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AOX1 aldehyde oxidase 1
ATAD5 ATPase family, AAA domain containing 5
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BMP15 bone morphogenetic protein 15
BMP4 bone morphogenetic protein 4
BRCA2 breast cancer 2, early onset
C21ORF2 chromosome 21 open reading frame 2
C22ORF46 chromosome 22 open reading frame 46
CAMK1 calcium/calmodulin-dependent protein kinase I
CASD1 CAS1 domain containing 1
CASP8 caspase 8, apoptosis-related cysteine peptidase
COBL cordon-bleu WH2 repeat protein
COPS7B COP9 signalosome subunit 7B
CPE carboxypeptidase E
CSE1L CSE1 chromosome segregation 1-like (yeast)
CST6 cystatin E/M
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DIO2 deiodinase, iodothyronine, type II
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EML3 echinoderm microtubule associated protein like 3
ETNK2 ethanolamine kinase 2
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GADD45G growth arrest and DNA-damage-inducible, gamma
GAMT guanidinoacetate N-methyltransferase
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPR27 G protein-coupled receptor 27
GUSBP3 glucuronidase, beta pseudogene 3
HCFC2 host cell factor C2
HPS1 Hermansky-Pudlak syndrome 1
HSPG2 heparan sulfate proteoglycan 2
IDI2-AS1 IDI2 antisense RNA 1
IMPG2 interphotoreceptor matrix proteoglycan 2
INTS5 integrator complex subunit 5
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRS2 insulin receptor substrate 2
ITFG2 integrin alpha FG-GAP repeat containing 2
KHK ketohexokinase (fructokinase)
KLF4 Kruppel-like factor 4 (gut)
LIG4 ligase IV, DNA, ATP-dependent
LMF2 lipase maturation factor 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MATK megakaryocyte-associated tyrosine kinase
MTAP methylthioadenosine phosphorylase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC1 mucin 1, cell surface associated
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NEK1 NIMA-related kinase 1
NF2 neurofibromin 2 (merlin)
NR2C1 nuclear receptor subfamily 2, group C, member 1
NRCAM neuronal cell adhesion molecule
NXPH4 neurexophilin 4
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PGBD5 piggyBac transposable element derived 5
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PRDX2 peroxiredoxin 2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTK6 protein tyrosine kinase 6
QKI QKI, KH domain containing, RNA binding
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF24 ring finger protein 24
RNF39 ring finger protein 39
RNFT1 ring finger protein, transmembrane 1
RPL13P5 ribosomal protein L13 pseudogene 5
RUFY3 RUN and FYVE domain containing 3
SCN1B sodium channel, voltage gated, type I beta subunit
SENP5 SUMO1/sentrin specific peptidase 5
SERHL2 serine hydrolase-like 2
SETD1A SET domain containing 1A
SFXN1 sideroflexin 1
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC25A44 solute carrier family 25, member 44
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SND1-IT1 SND1 intronic transcript 1
SPTBN1 spectrin, beta, non-erythrocytic 1
STC1 stanniocalcin 1
SYNGR1 synaptogyrin 1
TGFA transforming growth factor, alpha
TGFB2 transforming growth factor, beta 2
TLR5 toll-like receptor 5
TMEM53 transmembrane protein 53
TRABD TraB domain containing
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
USP2 ubiquitin specific peptidase 2
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XDH xanthine dehydrogenase
YY1 YY1 transcription factor
ZFPL1 zinc finger protein-like 1
ZNF219 zinc finger protein 219
ZNF510 zinc finger protein 510
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
AXIN1 axin 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
C19ORF24 chromosome 19 open reading frame 24
C19ORF40 chromosome 19 open reading frame 40
C22ORF29 chromosome 22 open reading frame 29
C5 complement component 5
C6ORF47 chromosome 6 open reading frame 47
CAPG capping protein (actin filament), gelsolin-like
CDK3 cyclin-dependent kinase 3
CHMP7 charged multivesicular body protein 7
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CORT cortistatin
CTNNBIP1 catenin, beta interacting protein 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DCAF17 DDB1 and CUL4 associated factor 17
DDIT3 DNA-damage-inducible transcript 3
DUSP4 dual specificity phosphatase 4
EAF2 ELL associated factor 2
EFNA4 ephrin-A4
EIF5A2 eukaryotic translation initiation factor 5A2
ERN2 endoplasmic reticulum to nucleus signaling 2
EVPL envoplakin
FOSL1 FOS-like antigen 1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GHR growth hormone receptor
GLI3 GLI family zinc finger 3
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNL1 guanine nucleotide binding protein-like 1
GPR87 G protein-coupled receptor 87
HIST1H1E histone cluster 1, H1e
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HPS6 Hermansky-Pudlak syndrome 6
INO80D INO80 complex subunit D
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JUNB jun B proto-oncogene
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLK5 kallikrein-related peptidase 5
KRI1 KRI1 homolog (S. cerevisiae)
KRT13 keratin 13, type I
LAMA3 laminin, alpha 3
LRP5L low density lipoprotein receptor-related protein 5-like
LRP6 low density lipoprotein receptor-related protein 6
LYPLA2P1 lysophospholipase II pseudogene 1
LZTR1 leucine-zipper-like transcription regulator 1
MAGEF1 melanoma antigen family F1
MAMLD1 mastermind-like domain containing 1
MANBA mannosidase, beta A, lysosomal
MB myoglobin
METTL2B methyltransferase like 2B
MRPL2 mitochondrial ribosomal protein L2
MVD mevalonate (diphospho) decarboxylase
MXD3 MAX dimerization protein 3
MYL5 myosin, light chain 5, regulatory
NDRG4 NDRG family member 4
NLK nemo-like kinase
NOTCH1 notch 1
NUCB1 nucleobindin 1
ONECUT2 one cut homeobox 2
PAQR3 progestin and adipoQ receptor family member III
PARP16 poly (ADP-ribose) polymerase family, member 16
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PMP22 peripheral myelin protein 22
PRR14L proline rich 14-like
PTPRU protein tyrosine phosphatase, receptor type, U
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIPK4 receptor-interacting serine-threonine kinase 4
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC16A6 solute carrier family 16, member 6
SLC46A3 solute carrier family 46, member 3
SOX12 SRY (sex determining region Y)-box 12
SOX3 SRY (sex determining region Y)-box 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TMC7 transmembrane channel-like 7
TMEM180 transmembrane protein 180
TMEM51 transmembrane protein 51
TMEM62 transmembrane protein 62
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
USP18 ubiquitin specific peptidase 18
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VAV1 vav 1 guanine nucleotide exchange factor
XYLT2 xylosyltransferase II
ZNF205 zinc finger protein 205
ZNF254 zinc finger protein 254
ZNF675 zinc finger protein 675
ZNF767P zinc finger family member 767, pseudogene
ZNF770 zinc finger protein 770