tranexamic acid-5762 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the tranexamic acid-5762 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ABHD8 abhydrolase domain containing 8
ACSL5 acyl-CoA synthetase long-chain family member 5
AHNAK AHNAK nucleoprotein
APOC4 apolipoprotein C-IV
ATP9A ATPase, class II, type 9A
BET1L Bet1 golgi vesicular membrane trafficking protein-like
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C2CD2L C2CD2-like
C7ORF69 chromosome 7 open reading frame 69
CA14 carbonic anhydrase XIV
CA5B carbonic anhydrase VB, mitochondrial
CA9 carbonic anhydrase IX
CCDC71 coiled-coil domain containing 71
CD34 CD34 molecule
CD48 CD48 molecule
CHI3L2 chitinase 3-like 2
CLCA1 chloride channel accessory 1
CLCN7 chloride channel, voltage-sensitive 7
CNTN6 contactin 6
COL14A1 collagen, type XIV, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CRH corticotropin releasing hormone
CRMP1 collapsin response mediator protein 1
CROCCP3 ciliary rootlet coiled-coil, rootletin pseudogene 3
CTSG cathepsin G
CYLD cylindromatosis (turban tumor syndrome)
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DENND2A DENN/MADD domain containing 2A
DPF1 D4, zinc and double PHD fingers family 1
EPS8L1 EPS8-like 1
ERC1 ELKS/RAB6-interacting/CAST family member 1
FAM65B family with sequence similarity 65, member B
FAT4 FAT atypical cadherin 4
GPM6A glycoprotein M6A
GREB1L growth regulation by estrogen in breast cancer-like
GREM2 gremlin 2, DAN family BMP antagonist
GRTP1 growth hormone regulated TBC protein 1
GYG2 glycogenin 2
HAP1 huntingtin-associated protein 1
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HIST1H1D histone cluster 1, H1d
HOXD11 homeobox D11
HSPB6 heat shock protein, alpha-crystallin-related, B6
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
ICOSLG inducible T-cell co-stimulator ligand
IL36RN interleukin 36 receptor antagonist
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KIAA1549L KIAA1549-like
LAG3 lymphocyte-activation gene 3
LINC00115 long intergenic non-protein coding RNA 115
LMOD1 leiomodin 1 (smooth muscle)
MEGF8 multiple EGF-like-domains 8
MFAP3L microfibrillar-associated protein 3-like
MLANA melan-A
MPZ myelin protein zero
MYEF2 myelin expression factor 2
NAGLU N-acetylglucosaminidase, alpha
NKX3-1 NK3 homeobox 1
NRXN3 neurexin 3
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSGIN1 oxidative stress induced growth inhibitor 1
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
POMT2 protein-O-mannosyltransferase 2
PRKG2 protein kinase, cGMP-dependent, type II
PTK7 protein tyrosine kinase 7 (inactive)
QPRT quinolinate phosphoribosyltransferase
RRH retinal pigment epithelium-derived rhodopsin homolog
RUNX2 runt-related transcription factor 2
SAFB scaffold attachment factor B
SCAPER S-phase cyclin A-associated protein in the ER
SEPP1 selenoprotein P, plasma, 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMAD7 SMAD family member 7
SMC1A structural maintenance of chromosomes 1A
SOCS3 suppressor of cytokine signaling 3
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
T T, brachyury homolog (mouse)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF5 transmembrane 4 L six family member 5
TNS1 tensin 1
TNS4 tensin 4
TP53I11 tumor protein p53 inducible protein 11
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TSC22D4 TSC22 domain family, member 4
TULP2 tubby like protein 2
USB1 U6 snRNA biogenesis 1
VAV1 vav 1 guanine nucleotide exchange factor
VEZT vezatin, adherens junctions transmembrane protein
WTAP Wilms tumor 1 associated protein
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
YIPF2 Yip1 domain family, member 2
ZCCHC11 zinc finger, CCHC domain containing 11
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
AMT aminomethyltransferase
ANP32A-IT1 ANP32A intronic transcript 1
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAHCC1 BAH domain and coiled-coil containing 1
BAK1 BCL2-antagonist/killer 1
BMP15 bone morphogenetic protein 15
C5ORF30 chromosome 5 open reading frame 30
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDK3 cyclin-dependent kinase 3
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CES3 carboxylesterase 3
CHM choroideremia (Rab escort protein 1)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLEC2B C-type lectin domain family 2, member B
CNGB3 cyclic nucleotide gated channel beta 3
CRLF1 cytokine receptor-like factor 1
DDN dendrin
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DHRS9 dehydrogenase/reductase (SDR family) member 9
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF5A2 eukaryotic translation initiation factor 5A2
FGL1 fibrinogen-like 1
FOXN2 forkhead box N2
FUZ fuzzy planar cell polarity protein
GAL3ST4 galactose-3-O-sulfotransferase 4
GALK1 galactokinase 1
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GRB7 growth factor receptor-bound protein 7
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AI histone cluster 1, H2ai
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BM histone cluster 1, H2bm
HIST1H3G histone cluster 1, H3g
HIST1H4D histone cluster 1, H4d
HOXA2 homeobox A2
HOXA7 homeobox A7
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IFNA14 interferon, alpha 14
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL12A interleukin 12A
IL7 interleukin 7
INCENP inner centromere protein antigens 135/155kDa
IRF6 interferon regulatory factor 6
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KRT31 keratin 31, type I
LIPG lipase, endothelial
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MFSD6 major facilitator superfamily domain containing 6
MILR1 mast cell immunoglobulin-like receptor 1
MRAS muscle RAS oncogene homolog
MXRA8 matrix-remodelling associated 8
MYH15 myosin, heavy chain 15
NAG18 NAG18 mRNA
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPFFR1 neuropeptide FF receptor 1
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NUP62CL nucleoporin 62kDa C-terminal like
ORAI3 ORAI calcium release-activated calcium modulator 3
OSMR oncostatin M receptor
PER3 period circadian clock 3
PGPEP1 pyroglutamyl-peptidase I
PHLDA3 pleckstrin homology-like domain, family A, member 3
PPT2 palmitoyl-protein thioesterase 2
PRAMEF11 PRAME family member 11
PVRL3 poliovirus receptor-related 3
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RHOBTB2 Rho-related BTB domain containing 2
S100A3 S100 calcium binding protein A3
SCN10A sodium channel, voltage gated, type X alpha subunit
SHPK sedoheptulokinase
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLMO1 slowmo homolog 1 (Drosophila)
SRD5A3 steroid 5 alpha-reductase 3
SUGCT succinyl-CoA:glutarate-CoA transferase
SULT4A1 sulfotransferase family 4A, member 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TCEAL2 transcription elongation factor A (SII)-like 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIGD6 tigger transposable element derived 6
TPRA1 transmembrane protein, adipocyte asscociated 1
UGT8 UDP glycosyltransferase 8
ZNF205 zinc finger protein 205
ZNF230 zinc finger protein 230
ZNF41 zinc finger protein 41
ZNF671 zinc finger protein 671
ZNRD1-AS1 ZNRD1 antisense RNA 1