tranexamic acid-2248 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the tranexamic acid-2248 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK4 aarF domain containing kinase 4
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AIF1 allograft inflammatory factor 1
ALDOB aldolase B, fructose-bisphosphate
APAF1 apoptotic peptidase activating factor 1
APC2 adenomatosis polyposis coli 2
ARHGAP35 Rho GTPase activating protein 35
ARID4B AT rich interactive domain 4B (RBP1-like)
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCAN brevican
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCO1 beta-carotene oxygenase 1
C4BPA complement component 4 binding protein, alpha
CFDP1 craniofacial development protein 1
CFLAR CASP8 and FADD-like apoptosis regulator
CLDN18 claudin 18
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DGCR8 DGCR8 microprocessor complex subunit
DMPK dystrophia myotonica-protein kinase
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EPHB1 EPH receptor B1
FAM76A family with sequence similarity 76, member A
FBLN1 fibulin 1
FRMD1 FERM domain containing 1
FXYD5 FXYD domain containing ion transport regulator 5
GGT1 gamma-glutamyltransferase 1
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GREB1L growth regulation by estrogen in breast cancer-like
GSTP1 glutathione S-transferase pi 1
GTDC1 glycosyltransferase-like domain containing 1
GTPBP1 GTP binding protein 1
GUSBP3 glucuronidase, beta pseudogene 3
HDAC6 histone deacetylase 6
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
IL23A interleukin 23, alpha subunit p19
IQCC IQ motif containing C
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KHSRP KH-type splicing regulatory protein
KLF13 Kruppel-like factor 13
LAMP1 lysosomal-associated membrane protein 1
LOC100286895 cell division cycle 27 homolog pseudogene
LRP12 low density lipoprotein receptor-related protein 12
MAGEA6 melanoma antigen family A6
MAN1A2 mannosidase, alpha, class 1A, member 2
MAN1C1 mannosidase, alpha, class 1C, member 1
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MLN motilin
MMP25 matrix metallopeptidase 25
MORN1 MORN repeat containing 1
MSL3 male-specific lethal 3 homolog (Drosophila)
MX2 MX dynamin-like GTPase 2
MYL10 myosin, light chain 10, regulatory
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NELL2 NEL-like 2 (chicken)
NF2 neurofibromin 2 (merlin)
NOP16 NOP16 nucleolar protein
NR2E3 nuclear receptor subfamily 2, group E, member 3
NR2F1 nuclear receptor subfamily 2, group F, member 1
ONECUT2 one cut homeobox 2
PARD6B par-6 family cell polarity regulator beta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCD1 phospholipase C, delta 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POPDC3 popeye domain containing 3
PRB4 proline-rich protein BstNI subfamily 4
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RND1 Rho family GTPase 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RUSC2 RUN and SH3 domain containing 2
S100A8 S100 calcium binding protein A8
SCD5 stearoyl-CoA desaturase 5
SCN11A sodium channel, voltage gated, type XI alpha subunit
SH3GL3 SH3-domain GRB2-like 3
SLN sarcolipin
SMIM14 small integral membrane protein 14
SPEG SPEG complex locus
STXBP5L syntaxin binding protein 5-like
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAGLN3 transgelin 3
TFEB transcription factor EB
TG thyroglobulin
TMEM209 transmembrane protein 209
TOR4A torsin family 4, member A
TPM2 tropomyosin 2 (beta)
TRIM29 tripartite motif containing 29
UBQLN4 ubiquilin 4
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
WDR62 WD repeat domain 62
ZFR zinc finger RNA binding protein
ZNF236 zinc finger protein 236
ZNF721 zinc finger protein 721
ZNF862 zinc finger protein 862
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
AFAP1 actin filament associated protein 1
ALOX15 arachidonate 15-lipoxygenase
ANKRD7 ankyrin repeat domain 7
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARHGAP4 Rho GTPase activating protein 4
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
BMP4 bone morphogenetic protein 4
C1ORF54 chromosome 1 open reading frame 54
C3 complement component 3
CCDC71 coiled-coil domain containing 71
CCNO cyclin O
CCP110 centriolar coiled coil protein 110kDa
CD80 CD80 molecule
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CIC capicua transcriptional repressor
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CORT cortistatin
CSF1R colony stimulating factor 1 receptor
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DMTN dematin actin binding protein
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPHA2 EPH receptor A2
ETAA1 Ewing tumor-associated antigen 1
EXO5 exonuclease 5
FAM110B family with sequence similarity 110, member B
FBXL8 F-box and leucine-rich repeat protein 8
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GIF gastric intrinsic factor (vitamin B synthesis)
GJA9 gap junction protein, alpha 9, 59kDa
GLS2 glutaminase 2 (liver, mitochondrial)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPATCH3 G patch domain containing 3
GSTM5 glutathione S-transferase mu 5
HDAC11 histone deacetylase 11
INPP1 inositol polyphosphate-1-phosphatase
KIAA0319L KIAA0319-like
KRT15 keratin 15, type I
LIN7B lin-7 homolog B (C. elegans)
LOC390998 ribosomal protein L10 pseudogene
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MCOLN3 mucolipin 3
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYOZ1 myozenin 1
NOL10 nucleolar protein 10
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSGIN1 oxidative stress induced growth inhibitor 1
OVOL1 ovo-like zinc finger 1
PAIP2B poly(A) binding protein interacting protein 2B
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PEX26 peroxisomal biogenesis factor 26
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLM polymerase (DNA directed), mu
PTK6 protein tyrosine kinase 6
PTPRS protein tyrosine phosphatase, receptor type, S
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFPL1S RFPL1 antisense RNA 1
RNF39 ring finger protein 39
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
S100A9 S100 calcium binding protein A9
SEC14L2 SEC14-like 2 (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SETD1A SET domain containing 1A
SLIT2 slit homolog 2 (Drosophila)
ST5 suppression of tumorigenicity 5
SYCP2 synaptonemal complex protein 2
TBC1D19 TBC1 domain family, member 19
TCHH trichohyalin
TICAM1 toll-like receptor adaptor molecule 1
TIGD6 tigger transposable element derived 6
TMLHE trimethyllysine hydroxylase, epsilon
TMOD1 tropomodulin 1
TPCN1 two pore segment channel 1
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPAN2 tetraspanin 2
UBIAD1 UbiA prenyltransferase domain containing 1
UPP1 uridine phosphorylase 1
XDH xanthine dehydrogenase
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
YY2 YY2 transcription factor
ZNF204P zinc finger protein 204, pseudogene
ZNF205 zinc finger protein 205
ZNF428 zinc finger protein 428
ZNF532 zinc finger protein 532
ZNF747 zinc finger protein 747
ZSCAN2 zinc finger and SCAN domain containing 2