tranexamic acid-2085 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the tranexamic acid-2085 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD17B abhydrolase domain containing 17B
ABHD2 abhydrolase domain containing 2
ALPK1 alpha-kinase 1
ARHGAP6 Rho GTPase activating protein 6
ASAP1-IT1 ASAP1 intronic transcript 1
ATF6 activating transcription factor 6
BCAS3 breast carcinoma amplified sequence 3
BICD1 bicaudal D homolog 1 (Drosophila)
BTN3A1 butyrophilin, subfamily 3, member A1
C11ORF30 chromosome 11 open reading frame 30
C11ORF63 chromosome 11 open reading frame 63
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC88A coiled-coil domain containing 88A
CCPG1 cell cycle progression 1
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CEP152 centrosomal protein 152kDa
DND1 DND microRNA-mediated repression inhibitor 1
DSC2 desmocollin 2
DST dystonin
DTX2 deltex 2, E3 ubiquitin ligase
EFNA3 ephrin-A3
EHBP1 EH domain binding protein 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ETV5 ets variant 5
FAM105A family with sequence similarity 105, member A
FBXO38 F-box protein 38
FCF1 FCF1 rRNA-processing protein
FZD1 frizzled class receptor 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GLCE glucuronic acid epimerase
GPR137 G protein-coupled receptor 137
GPSM3 G-protein signaling modulator 3
GRAMD4 GRAM domain containing 4
GREM1 gremlin 1, DAN family BMP antagonist
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIST1H3B histone cluster 1, H3b
IL27RA interleukin 27 receptor, alpha
JMJD6 jumonji domain containing 6
KIAA0141 KIAA0141
KLHL28 kelch-like family member 28
LMAN1 lectin, mannose-binding, 1
LRP1 low density lipoprotein receptor-related protein 1
LRRC40 leucine rich repeat containing 40
LRRK1 leucine-rich repeat kinase 1
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MAPT microtubule-associated protein tau
MAX MYC associated factor X
MFN2 mitofusin 2
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MLX MLX, MAX dimerization protein
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYRF myelin regulatory factor
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NCKIPSD NCK interacting protein with SH3 domain
NCOA2 nuclear receptor coactivator 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NMT2 N-myristoyltransferase 2
NPFFR1 neuropeptide FF receptor 1
OSR2 odd-skipped related transciption factor 2
PEG3 paternally expressed 3
PLCH1 phospholipase C, eta 1
PQBP1 polyglutamine binding protein 1
PRKCI protein kinase C, iota
PSD3 pleckstrin and Sec7 domain containing 3
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPRA protein tyrosine phosphatase, receptor type, A
RAD52 RAD52 homolog (S. cerevisiae)
RBM12B-AS1 RBM12B antisense RNA 1
RDX radixin
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS12 regulator of G-protein signaling 12
RPP25 ribonuclease P/MRP 25kDa subunit
SCAMP1 secretory carrier membrane protein 1
SERGEF secretion regulating guanine nucleotide exchange factor
SERHL2 serine hydrolase-like 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SKI SKI proto-oncogene
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPRED2 sprouty-related, EVH1 domain containing 2
SS18 synovial sarcoma translocation, chromosome 18
STK24 serine/threonine kinase 24
STK4 serine/threonine kinase 4
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBC1D4 TBC1 domain family, member 4
THBD thrombomodulin
TMEM40 transmembrane protein 40
TMEM53 transmembrane protein 53
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TTC38 tetratricopeptide repeat domain 38
WDR1 WD repeat domain 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WNK1 WNK lysine deficient protein kinase 1
ZNF286A zinc finger protein 286A
ZNF41 zinc finger protein 41
ZNF500 zinc finger protein 500
ZNF675 zinc finger protein 675

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ACYP2 acylphosphatase 2, muscle type
ADCY6 adenylate cyclase 6
AFAP1 actin filament associated protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ATP10D ATPase, class V, type 10D
BRAF B-Raf proto-oncogene, serine/threonine kinase
C7ORF69 chromosome 7 open reading frame 69
CALCOCO1 calcium binding and coiled-coil domain 1
CCDC85C coiled-coil domain containing 85C
CLDN1 claudin 1
CLDN15 claudin 15
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CST4 cystatin S
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DCLRE1B DNA cross-link repair 1B
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DENND2D DENN/MADD domain containing 2D
DNM3 dynamin 3
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EDN1 endothelin 1
EIF5A2 eukaryotic translation initiation factor 5A2
ERF Ets2 repressor factor
ETAA1 Ewing tumor-associated antigen 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM155A family with sequence similarity 155, member A
FBXO2 F-box protein 2
FBXW12 F-box and WD repeat domain containing 12
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLCN folliculin
GALE UDP-galactose-4-epimerase
GDAP1 ganglioside induced differentiation associated protein 1
GPR1 G protein-coupled receptor 1
GRPR gastrin-releasing peptide receptor
GSTZ1 glutathione S-transferase zeta 1
H1F0 H1 histone family, member 0
HDAC7 histone deacetylase 7
HIRA histone cell cycle regulator
HOXC10 homeobox C10
HYAL3 hyaluronoglucosaminidase 3
HYI hydroxypyruvate isomerase (putative)
KDM5C lysine (K)-specific demethylase 5C
KIAA1549L KIAA1549-like
LHFP lipoma HMGIC fusion partner
LRRC37A2 leucine rich repeat containing 37, member A2
MAGEH1 melanoma antigen family H1
MED15 mediator complex subunit 15
MED9 mediator complex subunit 9
MYL5 myosin, light chain 5, regulatory
NGF nerve growth factor (beta polypeptide)
NPM3 nucleophosmin/nucleoplasmin 3
NSD1 nuclear receptor binding SET domain protein 1
NUBP2 nucleotide binding protein 2
NUP62CL nucleoporin 62kDa C-terminal like
OLFML2A olfactomedin-like 2A
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAQR3 progestin and adipoQ receptor family member III
PARD6A par-6 family cell polarity regulator alpha
PDGFRL platelet-derived growth factor receptor-like
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
RARS arginyl-tRNA synthetase
RASA2 RAS p21 protein activator 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RUSC2 RUN and SH3 domain containing 2
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SCML2 sex comb on midleg-like 2 (Drosophila)
SDC3 syndecan 3
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC22A18 solute carrier family 22, member 18
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SPEG SPEG complex locus
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STIM1 stromal interaction molecule 1
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
SYT17 synaptotagmin XVII
SYTL2 synaptotagmin-like 2
TBX19 T-box 19
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TNRC6B trinucleotide repeat containing 6B
TRDMT1 tRNA aspartic acid methyltransferase 1
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
ZC3H12A zinc finger CCCH-type containing 12A
ZNF212 zinc finger protein 212
ZNF250 zinc finger protein 250
ZNF273 zinc finger protein 273
ZNF276 zinc finger protein 276
ZNF574 zinc finger protein 574
ZNF668 zinc finger protein 668
ZNF701 zinc finger protein 701