tranexamic acid-1401 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the tranexamic acid-1401 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
ADK adenosine kinase
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ATG13 autophagy related 13
ATXN7 ataxin 7
AZIN1 antizyme inhibitor 1
BCOR BCL6 corepressor
C5ORF28 chromosome 5 open reading frame 28
CAMK1G calcium/calmodulin-dependent protein kinase IG
CBX6 chromobox homolog 6
CCPG1 cell cycle progression 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CLTA clathrin, light chain A
CNOT8 CCR4-NOT transcription complex, subunit 8
CRYM crystallin, mu
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAAF2 dynein, axonemal, assembly factor 2
DPYD dihydropyrimidine dehydrogenase
DSCR3 Down syndrome critical region 3
ECT2 epithelial cell transforming 2
EFCAB14 EF-hand calcium binding domain 14
EID1 EP300 interacting inhibitor of differentiation 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EVI5 ecotropic viral integration site 5
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FUBP3 far upstream element (FUSE) binding protein 3
GLS glutaminase
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GSPT1 G1 to S phase transition 1
HIST1H4C histone cluster 1, H4c
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOOK2 hook microtubule-tethering protein 2
IL1RAP interleukin 1 receptor accessory protein
ITM2B integral membrane protein 2B
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIAA1598
KRI1 KRI1 homolog (S. cerevisiae)
LAMP2 lysosomal-associated membrane protein 2
LIN7C lin-7 homolog C (C. elegans)
LMAN1 lectin, mannose-binding, 1
MAGOHB mago-nashi homolog B (Drosophila)
MAGT1 magnesium transporter 1
MED31 mediator complex subunit 31
MED4 mediator complex subunit 4
MIS18BP1 MIS18 binding protein 1
MORC3 MORC family CW-type zinc finger 3
MTM1 myotubularin 1
PAK1IP1 PAK1 interacting protein 1
PCBP2 poly(rC) binding protein 2
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDCD11 programmed cell death 11
PKNOX1 PBX/knotted 1 homeobox 1
PLCD1 phospholipase C, delta 1
PLK4 polo-like kinase 4
POTEKP POTE ankyrin domain family, member K, pseudogene
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRMT3 protein arginine methyltransferase 3
PRPF39 pre-mRNA processing factor 39
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PSG3 pregnancy specific beta-1-glycoprotein 3
PSPH phosphoserine phosphatase
PTBP3 polypyrimidine tract binding protein 3
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB14 RAB14, member RAS oncogene family
RAD21 RAD21 homolog (S. pombe)
RB1CC1 RB1-inducible coiled-coil 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RFK riboflavin kinase
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RPL27A ribosomal protein L27a
RWDD3 RWD domain containing 3
SAMHD1 SAM domain and HD domain 1
SEC23B Sec23 homolog B (S. cerevisiae)
SIK2 salt-inducible kinase 2
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLMO2 slowmo homolog 2 (Drosophila)
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SPG20 spastic paraplegia 20 (Troyer syndrome)
SSR1 signal sequence receptor, alpha
STAG2 stromal antigen 2
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TES testin LIM domain protein
TET3 tet methylcytosine dioxygenase 3
TMED7 transmembrane emp24 protein transport domain containing 7
TOB1 transducer of ERBB2, 1
TROVE2 TROVE domain family, member 2
UGDH UDP-glucose 6-dehydrogenase
USF2 upstream transcription factor 2, c-fos interacting
ZEB2 zinc finger E-box binding homeobox 2
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
AATK apoptosis-associated tyrosine kinase
ACP2 acid phosphatase 2, lysosomal
APOBR apolipoprotein B receptor
ASCC1 activating signal cointegrator 1 complex subunit 1
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
AXIN1 axin 1
BAHD1 bromo adjacent homology domain containing 1
BCORL1 BCL6 corepressor-like 1
C11ORF68 chromosome 11 open reading frame 68
C2ORF47 chromosome 2 open reading frame 47
CD151 CD151 molecule (Raph blood group)
CEP131 centrosomal protein 131kDa
CER1 cerberus 1, DAN family BMP antagonist
CHPT1 choline phosphotransferase 1
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CNTD2 cyclin N-terminal domain containing 2
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRYL1 crystallin, lambda 1
CS citrate synthase
CYB5R3 cytochrome b5 reductase 3
DAO D-amino-acid oxidase
DBF4 DBF4 zinc finger
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DOK2 docking protein 2, 56kDa
DSN1 DSN1, MIS12 kinetochore complex component
EAPP E2F-associated phosphoprotein
FBXL6 F-box and leucine-rich repeat protein 6
FBXO46 F-box protein 46
FICD FIC domain containing
FMNL1 formin-like 1
GAA glucosidase, alpha; acid
GLB1L2 galactosidase, beta 1-like 2
GPR27 G protein-coupled receptor 27
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL17RA interleukin 17 receptor A
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
KIF5A kinesin family member 5A
KIFAP3 kinesin-associated protein 3
KIZ kizuna centrosomal protein
KLF10 Kruppel-like factor 10
LENEP lens epithelial protein
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
MAEA macrophage erythroblast attacher
MAGEF1 melanoma antigen family F1
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAPK3 mitogen-activated protein kinase 3
MLYCD malonyl-CoA decarboxylase
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MUC3A mucin 3A, cell surface associated
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NOL12 nucleolar protein 12
NQO2 NAD(P)H dehydrogenase, quinone 2
NRGN neurogranin (protein kinase C substrate, RC3)
NUBP2 nucleotide binding protein 2
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
PALM paralemmin
PGPEP1 pyroglutamyl-peptidase I
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PMM2 phosphomannomutase 2
PNRC1 proline-rich nuclear receptor coactivator 1
POLE polymerase (DNA directed), epsilon, catalytic subunit
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
RABL6 RAB, member RAS oncogene family-like 6
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RINT1 RAD50 interactor 1
RNF122 ring finger protein 122
RPS21 ribosomal protein S21
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGA Ras-related GTP binding A
SEPHS2 selenophosphate synthetase 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLN sarcolipin
SLPI secretory leukocyte peptidase inhibitor
SP140L SP140 nuclear body protein-like
SPATA20 spermatogenesis associated 20
STARD8 StAR-related lipid transfer (START) domain containing 8
STRN4 striatin, calmodulin binding protein 4
TESK2 testis-specific kinase 2
THEM6 thioesterase superfamily member 6
TIAM2 T-cell lymphoma invasion and metastasis 2
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSPAN32 tetraspanin 32
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
TUBB6 tubulin, beta 6 class V
WDR3 WD repeat domain 3
WFDC2 WAP four-disulfide core domain 2
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
YIPF1 Yip1 domain family, member 1
YY2 YY2 transcription factor
ZDHHC7 zinc finger, DHHC-type containing 7
ZNF250 zinc finger protein 250