toxic shock syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities. (Human Disease Ontology, DOID_14115)
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Genes

140 genes co-occuring with the disease toxic shock syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SPEG SPEG complex locus 1.68906
BTNL2 butyrophilin-like 2 1.59608
FUT2 fucosyltransferase 2 (secretor status included) 1.46715
TNF tumor necrosis factor 1.44957
TYMS thymidylate synthetase 1.37294
SELO selenoprotein O 1.35594
GML glycosylphosphatidylinositol anchored molecule like 1.31056
SELM selenoprotein M 1.3027
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 1.27999
SELK selenoprotein K 1.24819
CD4 CD4 molecule 1.18109
IL1B interleukin 1, beta 1.1456
IL2 interleukin 2 1.14305
EPHA4 EPH receptor A4 1.13966
LTA lymphotoxin alpha 1.11267
SUMF2 sulfatase modifying factor 2 1.11225
PDE12 phosphodiesterase 12 1.0795
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 1.07152
TYRL tyrosinase-like (pseudogene) 0.911022
TST thiosulfate sulfurtransferase (rhodanese) 0.91061
TSKU tsukushi, small leucine rich proteoglycan 0.863865
IL10 interleukin 10 0.858543
TXNDC17 thioredoxin domain containing 17 0.819616
TLR2 toll-like receptor 2 0.761454
IL1A interleukin 1, alpha 0.759824
ETV2 ets variant 2 0.758193
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.747204
CXCL8 chemokine (C-X-C motif) ligand 8 0.747204
IL6 interleukin 6 0.743547
HLA-DMA major histocompatibility complex, class II, DM alpha 0.741517
C5AR1 complement component 5a receptor 1 0.736243
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 0.730571
TSN translin 0.704742
CD69 CD69 molecule 0.656441
CD40 CD40 molecule, TNF receptor superfamily member 5 0.651694
KLRC1 killer cell lectin-like receptor subfamily C, member 1 0.650903
CD46 CD46 molecule, complement regulatory protein 0.648533
EDNRA endothelin receptor type A 0.642221
PGLYRP2 peptidoglycan recognition protein 2 0.641827
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.639463
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.632384
PLCG1 phospholipase C, gamma 1 0.613574
TLR4 toll-like receptor 4 0.53928
AGR3 anterior gradient 3 0.524974
TP63 tumor protein p63 0.517265
MYD88 myeloid differentiation primary response 88 0.514186
SELPLG selectin P ligand 0.506123
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker) 0.495793
AZU1 azurocidin 1 0.491597
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.489691
NRL neural retina leucine zipper 0.489311
CD276 CD276 molecule 0.481705
HLA-C major histocompatibility complex, class I, C 0.472604
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.460129
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.460129
KLRC3 killer cell lectin-like receptor subfamily C, member 3 0.458996
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 0.449947
CD79A CD79a molecule, immunoglobulin-associated alpha 0.446558
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 0.42739
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.42289
PRF1 perforin 1 (pore forming protein) 0.416147
ADGRL4 adhesion G protein-coupled receptor L4 0.413901
ST5 suppression of tumorigenicity 5 0.409787
RND3 Rho family GTPase 3 0.40904
CCL2 chemokine (C-C motif) ligand 2 0.398589
CDR1 cerebellar degeneration-related protein 1, 34kDa 0.387423
CBS cystathionine-beta-synthase 0.386308
SEPT1 septin 1 0.385565
PERP PERP, TP53 apoptosis effector 0.36187
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.352291
KDM6B lysine (K)-specific demethylase 6B 0.351923
IRF7 interferon regulatory factor 7 0.348246
FN1 fibronectin 1 0.333218
CD1A CD1a molecule 0.325187
PPA1 pyrophosphatase (inorganic) 1 0.323365
KLRC2 killer cell lectin-like receptor subfamily C, member 2 0.320454
ALB albumin 0.32009
NT5C1A 5'-nucleotidase, cytosolic IA 0.319726
MGAM maltase-glucoamylase 0.318272
ZC3H12D zinc finger CCCH-type containing 12D 0.312827
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.30342
CCL3 chemokine (C-C motif) ligand 3 0.301615
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.300533
CD1B CD1b molecule 0.298731
EPS15 epidermal growth factor receptor pathway substrate 15 0.298731
RAET1E retinoic acid early transcript 1E 0.294772
LRG1 leucine-rich alpha-2-glycoprotein 1 0.294053
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.287235
HLA-E major histocompatibility complex, class I, E 0.283297
AANAT aralkylamine N-acetyltransferase 0.282582
MGP matrix Gla protein 0.282225
NT5C2 5'-nucleotidase, cytosolic II 0.281868
CD14 CD14 molecule 0.280082
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.274732
DHFR dihydrofolate reductase 0.272597
IL4 interleukin 4 0.267622
GMPS guanine monphosphate synthase 0.264431
GH2 growth hormone 2 0.264077
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.25877
IL15 interleukin 15 0.254183
HMGB1 high mobility group box 1 0.248203
MIR192 microRNA 192 0.243995
CRP C-reactive protein, pentraxin-related 0.243295
CD86 CD86 molecule 0.241546
IL11 interleukin 11 0.236312
ADAM17 ADAM metallopeptidase domain 17 0.228679
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A 0.227642
CSN1S1 casein alpha s1 0.22454
F3 coagulation factor III (thromboplastin, tissue factor) 0.223853
COCH cochlin 0.216332
CD58 CD58 molecule 0.213621
STAT4 signal transducer and activator of transcription 4 0.213621
SDC1 syndecan 1 0.208914
OMG oligodendrocyte myelin glycoprotein 0.205916
TSPO translocator protein (18kDa) 0.205254
IL2RA interleukin 2 receptor, alpha 0.203275
GAL galanin/GMAP prepropeptide 0.201962
CCL20 chemokine (C-C motif) ligand 20 0.194865
CD40LG CD40 ligand 0.194865
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.193285
IRF1 interferon regulatory factor 1 0.192657
EEA1 early endosome antigen 1 0.186811
SRPX2 sushi-repeat containing protein, X-linked 2 0.18651
TYR tyrosinase 0.185612
RAD52 RAD52 homolog (S. cerevisiae) 0.182086
AGR2 anterior gradient 2 0.181798
ARPP21 cAMP-regulated phosphoprotein, 21kDa 0.18151
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.17896
IPP intracisternal A particle-promoted polypeptide 0.175679
IRAK4 interleukin-1 receptor-associated kinase 4 0.172544
YME1L1 YME1-like 1 ATPase 0.172038
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.169091
F2 coagulation factor II (thrombin) 0.167915
STAT1 signal transducer and activator of transcription 1, 91kDa 0.165655
C5 complement component 5 0.163938
LIG1 ligase I, DNA, ATP-dependent 0.163111
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.162109
LTF lactotransferrin 0.161716
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.15948
GADD45B growth arrest and DNA-damage-inducible, beta 0.15948