tonzonium bromide-3080 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the tonzonium bromide-3080 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM8 ADAM metallopeptidase domain 8
AMPH amphiphysin
AQP9 aquaporin 9
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BDKRB1 bradykinin receptor B1
BTN2A2 butyrophilin, subfamily 2, member A2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C20ORF27 chromosome 20 open reading frame 27
C3ORF18 chromosome 3 open reading frame 18
CADM3 cell adhesion molecule 3
CAT catalase
CCDC92 coiled-coil domain containing 92
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
COL7A1 collagen, type VII, alpha 1
CYR61 cysteine-rich, angiogenic inducer, 61
DOCK1 dedicator of cytokinesis 1
DPEP2 dipeptidase 2
DRD2 dopamine receptor D2
EHD3 EH-domain containing 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FABP3 fatty acid binding protein 3, muscle and heart
FAM131A family with sequence similarity 131, member A
FAS Fas cell surface death receptor
FBXO22 F-box protein 22
FGF21 fibroblast growth factor 21
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GPM6B glycoprotein M6B
GPR182 G protein-coupled receptor 182
GRM1 glutamate receptor, metabotropic 1
HCG4 HLA complex group 4 (non-protein coding)
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXD1 homeobox D1
HRG histidine-rich glycoprotein
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA2 heat shock 70kDa protein 2
IFITM1 interferon induced transmembrane protein 1
IFNA17 interferon, alpha 17
IL1R2 interleukin 1 receptor, type II
IVL involucrin
KANK2 KN motif and ankyrin repeat domains 2
KIAA0513 KIAA0513
KLF12 Kruppel-like factor 12
KLF2 Kruppel-like factor 2
KLF5 Kruppel-like factor 5 (intestinal)
KRT8P12 keratin 8 pseudogene 12
LAMB4 laminin, beta 4
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRP5 low density lipoprotein receptor-related protein 5
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCAM melanoma cell adhesion molecule
MEGF8 multiple EGF-like-domains 8
METRN meteorin, glial cell differentiation regulator
MISP mitotic spindle positioning
MTUS1 microtubule associated tumor suppressor 1
MYL10 myosin, light chain 10, regulatory
NCR2 natural cytotoxicity triggering receptor 2
NEBL nebulette
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PDE4DIP phosphodiesterase 4D interacting protein
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PKNOX2 PBX/knotted 1 homeobox 2
PLD1 phospholipase D1, phosphatidylcholine-specific
PNMA3 paraneoplastic Ma antigen 3
POU2F2 POU class 2 homeobox 2
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PSD3 pleckstrin and Sec7 domain containing 3
PTCRA pre T-cell antigen receptor alpha
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PYGB phosphorylase, glycogen; brain
RAB3D RAB3D, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
RAG1 recombination activating gene 1
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
REC8 REC8 meiotic recombination protein
RNASE4 ribonuclease, RNase A family, 4
RPL18 ribosomal protein L18
RUNX2 runt-related transcription factor 2
SGK2 serum/glucocorticoid regulated kinase 2
SHB Src homology 2 domain containing adaptor protein B
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SORCS3 sortilin-related VPS10 domain containing receptor 3
SOX2 SRY (sex determining region Y)-box 2
SSPN sarcospan
TBC1D19 TBC1 domain family, member 19
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCEAL2 transcription elongation factor A (SII)-like 2
TNS1 tensin 1
TPMT thiopurine S-methyltransferase
TRAF4 TNF receptor-associated factor 4
XAB2 XPA binding protein 2
XDH xanthine dehydrogenase
YY1 YY1 transcription factor
ZFPL1 zinc finger protein-like 1
ZNF219 zinc finger protein 219
ZNF3 zinc finger protein 3
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ALS2CL ALS2 C-terminal like
ARG1 arginase 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BEND5 BEN domain containing 5
BLVRB biliverdin reductase B
BTBD2 BTB (POZ) domain containing 2
C7ORF43 chromosome 7 open reading frame 43
CCDC9 coiled-coil domain containing 9
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPT centromere protein T
CLDN7 claudin 7
CMTR1 cap methyltransferase 1
CORO7 coronin 7
CTSG cathepsin G
DENND1C DENN/MADD domain containing 1C
DENND5B DENN/MADD domain containing 5B
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DGKG diacylglycerol kinase, gamma 90kDa
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNAL4 dynein, axonemal, light chain 4
DNMBP dynamin binding protein
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
ELSPBP1 epididymal sperm binding protein 1
ERCC6L excision repair cross-complementation group 6-like
FAM114A1 family with sequence similarity 114, member A1
FAM57A family with sequence similarity 57, member A
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGGY FGGY carbohydrate kinase domain containing
FOXO4 forkhead box O4
FRMD1 FERM domain containing 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GDAP1 ganglioside induced differentiation associated protein 1
GPR3 G protein-coupled receptor 3
GRWD1 glutamate-rich WD repeat containing 1
HCAR3 hydroxycarboxylic acid receptor 3
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HIST1H3B histone cluster 1, H3b
HPS6 Hermansky-Pudlak syndrome 6
IFI6 interferon, alpha-inducible protein 6
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IQCG IQ motif containing G
JUNB jun B proto-oncogene
KIAA1024 KIAA1024
KPTN kaptin (actin binding protein)
LPPR1 lipid phosphate phosphatase-related protein type 1
LZTR1 leucine-zipper-like transcription regulator 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPKBP1 mitogen-activated protein kinase binding protein 1
MON1B MON1 secretory trafficking family member B
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NECAB3 N-terminal EF-hand calcium binding protein 3
NFE2L3 nuclear factor, erythroid 2-like 3
NINJ2 ninjurin 2
NPFFR1 neuropeptide FF receptor 1
NSD1 nuclear receptor binding SET domain protein 1
NT5DC3 5'-nucleotidase domain containing 3
PDE12 phosphodiesterase 12
PDLIM1 PDZ and LIM domain 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PECR peroxisomal trans-2-enoyl-CoA reductase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLS1 plastin 1
POM121 POM121 transmembrane nucleoporin
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDM1 PR domain containing 1, with ZNF domain
PRMT7 protein arginine methyltransferase 7
PROCR protein C receptor, endothelial
RAB23 RAB23, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RECQL4 RecQ protein-like 4
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF126P1 ring finger protein 126 pseudogene 1
SCGB2A2 secretoglobin, family 2A, member 2
SETD1A SET domain containing 1A
SIGLEC15 sialic acid binding Ig-like lectin 15
SPATA20 spermatogenesis associated 20
ST7L suppression of tumorigenicity 7 like
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STBD1 starch binding domain 1
TGFBR3 transforming growth factor, beta receptor III
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THAP10 THAP domain containing 10
THEM6 thioesterase superfamily member 6
TMEM212 transmembrane protein 212
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPM3 tropomyosin 3
TTC4 tetratricopeptide repeat domain 4
TUBG2 tubulin, gamma 2
ZC3H3 zinc finger CCCH-type containing 3
ZFAND3 zinc finger, AN1-type domain 3
ZNF280B zinc finger protein 280B
ZNF408 zinc finger protein 408
ZNF41 zinc finger protein 41
ZNF816 zinc finger protein 816