tolnaftate-4805 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the tolnaftate-4805 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AIDA axin interactor, dorsalization associated
AKAP10 A kinase (PRKA) anchor protein 10
AKTIP AKT interacting protein
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ATG5 autophagy related 5
ATM ATM serine/threonine kinase
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C6ORF62 chromosome 6 open reading frame 62
CA4 carbonic anhydrase IV
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALU calumenin
CAPRIN1 cell cycle associated protein 1
CCNG2 cyclin G2
CD46 CD46 molecule, complement regulatory protein
CDC25C cell division cycle 25C
CHRM3 cholinergic receptor, muscarinic 3
CLDND1 claudin domain containing 1
CLGN calmegin
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CTBS chitobiase, di-N-acetyl-
DEGS1 delta(4)-desaturase, sphingolipid 1
EFNA3 ephrin-A3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPOR erythropoietin receptor
ETNK1 ethanolamine kinase 1
EXOC5 exocyst complex component 5
FAS Fas cell surface death receptor
FDX1 ferredoxin 1
FFAR3 free fatty acid receptor 3
FH fumarate hydratase
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HSPA4 heat shock 70kDa protein 4
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KLF13 Kruppel-like factor 13
LINC00094 long intergenic non-protein coding RNA 94
LOC440434 aminopeptidase puromycin sensitive pseudogene
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MCL1 myeloid cell leukemia 1
MCM4 minichromosome maintenance complex component 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTM1 myotubularin 1
NCKAP1 NCK-associated protein 1
NEK3 NIMA-related kinase 3
NOTCH2 notch 2
NPR3 natriuretic peptide receptor 3
NXT2 nuclear transport factor 2-like export factor 2
PARD6B par-6 family cell polarity regulator beta
PICALM phosphatidylinositol binding clathrin assembly protein
POT1 protection of telomeres 1
PRPF4B pre-mRNA processing factor 4B
PSEN2 presenilin 2
PTCH1 patched 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB35 RAB35, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RALB v-ral simian leukemia viral oncogene homolog B
RARG retinoic acid receptor, gamma
RFC3 replication factor C (activator 1) 3, 38kDa
RNF146 ring finger protein 146
RNFT1 ring finger protein, transmembrane 1
RPS14 ribosomal protein S14
RRM1 ribonucleotide reductase M1
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SCAMP1 secretory carrier membrane protein 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SGPP1 sphingosine-1-phosphate phosphatase 1
SIRT4 sirtuin 4
SKI SKI proto-oncogene
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC35E2 solute carrier family 35, member E2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SNX13 sorting nexin 13
SNX2 sorting nexin 2
SOD2 superoxide dismutase 2, mitochondrial
SQLE squalene epoxidase
SRSF1 serine/arginine-rich splicing factor 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
SYCE1L synaptonemal complex central element protein 1-like
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TCP11L1 t-complex 11, testis-specific-like 1
TFDP1 transcription factor Dp-1
TMEM230 transmembrane protein 230
TRIM23 tripartite motif containing 23
VAMP3 vesicle-associated membrane protein 3
VAMP4 vesicle-associated membrane protein 4
WSB1 WD repeat and SOCS box containing 1
ZNF675 zinc finger protein 675

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ACTL8 actin-like 8
AHDC1 AT hook, DNA binding motif, containing 1
AP1B1 adaptor-related protein complex 1, beta 1 subunit
ARC activity-regulated cytoskeleton-associated protein
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARRB2 arrestin, beta 2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BBC3 BCL2 binding component 3
CD82 CD82 molecule
CTNNBL1 catenin, beta like 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM46C family with sequence similarity 46, member C
FBXL6 F-box and leucine-rich repeat protein 6
FHOD1 formin homology 2 domain containing 1
FSD1 fibronectin type III and SPRY domain containing 1
GBP2 guanylate binding protein 2, interferon-inducible
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GRTP1 growth hormone regulated TBC protein 1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMOX1 heme oxygenase 1
HOOK1 hook microtubule-tethering protein 1
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSPA1L heat shock 70kDa protein 1-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IQSEC2 IQ motif and Sec7 domain 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIAA0319L KIAA0319-like
KIF13A kinesin family member 13A
KLHL21 kelch-like family member 21
KRT8P12 keratin 8 pseudogene 12
LAMA3 laminin, alpha 3
LRRC8E leucine rich repeat containing 8 family, member E
MANBA mannosidase, beta A, lysosomal
MAP2 microtubule-associated protein 2
MAPK12 mitogen-activated protein kinase 12
MED24 mediator complex subunit 24
MFAP2 microfibrillar-associated protein 2
MFSD11 major facilitator superfamily domain containing 11
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MUC3B mucin 3B, cell surface associated
MVD mevalonate (diphospho) decarboxylase
NEUROD4 neuronal differentiation 4
NRGN neurogranin (protein kinase C substrate, RC3)
ONECUT2 one cut homeobox 2
PACS1 phosphofurin acidic cluster sorting protein 1
PCDHGA10 protocadherin gamma subfamily A, 10
PDE12 phosphodiesterase 12
PDE8B phosphodiesterase 8B
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLD2 phospholipase D2
PLD3 phospholipase D family, member 3
PTPRU protein tyrosine phosphatase, receptor type, U
PYCRL pyrroline-5-carboxylate reductase-like
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB36 RAB36, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBM19 RNA binding motif protein 19
RFWD3 ring finger and WD repeat domain 3
RIN1 Ras and Rab interactor 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF39 ring finger protein 39
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPAP1 RNA polymerase II associated protein 1
RPRD2 regulation of nuclear pre-mRNA domain containing 2
SCD5 stearoyl-CoA desaturase 5
SETD8 SET domain containing (lysine methyltransferase) 8
SH2D4A SH2 domain containing 4A
SLC12A9 solute carrier family 12, member 9
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
STEAP4 STEAP family member 4
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TPCN1 two pore segment channel 1
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TSSC4 tumor suppressing subtransferable candidate 4
TTBK2 tau tubulin kinase 2
TWF2 twinfilin actin binding protein 2
UBE2O ubiquitin-conjugating enzyme E2O
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
USP27X ubiquitin specific peptidase 27, X-linked
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR91 WD repeat domain 91
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H3 zinc finger CCCH-type containing 3
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF34 zinc finger protein 34
ZNF747 zinc finger protein 747
ZNHIT2 zinc finger, HIT-type containing 2