tolmetin-4088 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the tolmetin-4088 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8
ADGRA2 adhesion G protein-coupled receptor A2
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
CABP1 calcium binding protein 1
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCL2 chemokine (C-C motif) ligand 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CFP complement factor properdin
COL14A1 collagen, type XIV, alpha 1
CPZ carboxypeptidase Z
CSDC2 cold shock domain containing C2, RNA binding
CSF1R colony stimulating factor 1 receptor
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
FAM163A family with sequence similarity 163, member A
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial
FGF7 fibroblast growth factor 7
FLT4 fms-related tyrosine kinase 4
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPM6A glycoprotein M6A
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
HIST1H2AL histone cluster 1, H2al
HLA-DOA major histocompatibility complex, class II, DO alpha
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXD13 homeobox D13
HPR haptoglobin-related protein
HSPB3 heat shock 27kDa protein 3
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
IAPP islet amyloid polypeptide
IFNA14 interferon, alpha 14
IHH indian hedgehog
INS insulin
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
IZUMO4 IZUMO family member 4
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KERA keratocan
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KRT37 keratin 37, type I
KRTAP5-9 keratin associated protein 5-9
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEFTY2 left-right determination factor 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOC100287590 uncharacterized LOC100287590
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MMP10 matrix metallopeptidase 10
MTRF1L mitochondrial translational release factor 1-like
MTSS1 metastasis suppressor 1
MVB12B multivesicular body subunit 12B
MVD mevalonate (diphospho) decarboxylase
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NMRK2 nicotinamide riboside kinase 2
NRXN3 neurexin 3
OMD osteomodulin
PACRG PARK2 co-regulated
PAPPA2 pappalysin 2
PCDHB17P protocadherin beta 17 pseudogene
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G3 phospholipase A2, group III
PPARD peroxisome proliferator-activated receptor delta
PPEF1 protein phosphatase, EF-hand calcium binding domain 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRB4 proline-rich protein BstNI subfamily 4
PRM2 protamine 2
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RABGAP1L RAB GTPase activating protein 1-like
RARB retinoic acid receptor, beta
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RND2 Rho family GTPase 2
RNF43 ring finger protein 43
RPS6 ribosomal protein S6
RSU1 Ras suppressor protein 1
RTEL1 regulator of telomere elongation helicase 1
SARM1 sterile alpha and TIR motif containing 1
SASH3 SAM and SH3 domain containing 3
SCN2B sodium channel, voltage gated, type II beta subunit
SIX3 SIX homeobox 3
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10
SOGA1 suppressor of glucose, autophagy associated 1
SRPK3 SRSF protein kinase 3
SULF1 sulfatase 1
TACR1 tachykinin receptor 1
TBX1 T-box 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCF3 transcription factor 3
TLR4 toll-like receptor 4
TRGV5 T cell receptor gamma variable 5
TRIM15 tripartite motif containing 15
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)
ZC3H13 zinc finger CCCH-type containing 13
ZFP64 ZFP64 zinc finger protein
ZNF484 zinc finger protein 484
ZNF516 zinc finger protein 516
ZNF646 zinc finger protein 646

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ABHD17B abhydrolase domain containing 17B
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
AGMAT agmatine ureohydrolase (agmatinase)
ASCC1 activating signal cointegrator 1 complex subunit 1
ATG10 autophagy related 10
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BAGE B melanoma antigen
BICC1 BicC family RNA binding protein 1
BMP10 bone morphogenetic protein 10
C11ORF30 chromosome 11 open reading frame 30
C3AR1 complement component 3a receptor 1
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CAMKMT calmodulin-lysine N-methyltransferase
CEP70 centrosomal protein 70kDa
CFAP69 cilia and flagella associated protein 69
CLCA1 chloride channel accessory 1
CNN1 calponin 1, basic, smooth muscle
CNTFR ciliary neurotrophic factor receptor
CNTLN centlein, centrosomal protein
CRMP1 collapsin response mediator protein 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXORF21 chromosome X open reading frame 21
CYB5R2 cytochrome b5 reductase 2
DNAL4 dynein, axonemal, light chain 4
DOLK dolichol kinase
EXD3 exonuclease 3'-5' domain containing 3
FAM184A family with sequence similarity 184, member A
FBXO22 F-box protein 22
FBXO31 F-box protein 31
FKBP5 FK506 binding protein 5
FZD3 frizzled class receptor 3
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAN gigaxonin
GNA14 guanine nucleotide binding protein (G protein), alpha 14
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HHAT hedgehog acyltransferase
HIST1H1D histone cluster 1, H1d
HOXA4 homeobox A4
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIFC3 kinesin family member C3
LMCD1 LIM and cysteine-rich domains 1
LOC157562 uncharacterized LOC157562
LPAR3 lysophosphatidic acid receptor 3
LPPR4 lipid phosphate phosphatase-related protein type 4
LYPD3 LY6/PLAUR domain containing 3
MAST3 microtubule associated serine/threonine kinase 3
MATN3 matrilin 3
MCC mutated in colorectal cancers
MOCS3 molybdenum cofactor synthesis 3
MUC3A mucin 3A, cell surface associated
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPVF neuropeptide VF precursor
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PDE8B phosphodiesterase 8B
PHC1 polyhomeotic homolog 1 (Drosophila)
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
QPCTL glutaminyl-peptide cyclotransferase-like
RASAL2 RAS protein activator like 2
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNASE4 ribonuclease, RNase A family, 4
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SETD1A SET domain containing 1A
SLC25A40 solute carrier family 25, member 40
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLN sarcolipin
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPRYD7 SPRY domain containing 7
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
STK16 serine/threonine kinase 16
TENM4 teneurin transmembrane protein 4
THBS3 thrombospondin 3
THRAP3 thyroid hormone receptor associated protein 3
TMEM186 transmembrane protein 186
TMEM212 transmembrane protein 212
TMEM242 transmembrane protein 242
TUBA3C tubulin, alpha 3c
TUBA4B tubulin, alpha 4b
UNKL unkempt family zinc finger-like
YEATS4 YEATS domain containing 4
ZBTB22 zinc finger and BTB domain containing 22
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZMAT5 zinc finger, matrin-type 5
ZNF141 zinc finger protein 141
ZNF204P zinc finger protein 204, pseudogene
ZNF214 zinc finger protein 214
ZNF230 zinc finger protein 230
ZNF268 zinc finger protein 268
ZNF442 zinc finger protein 442
ZNF528 zinc finger protein 528
ZNF749 zinc finger protein 749
ZSCAN2 zinc finger and SCAN domain containing 2