tolmetin-3009 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the tolmetin-3009 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
APOD apolipoprotein D
ASB1 ankyrin repeat and SOCS box containing 1
ATP9A ATPase, class II, type 9A
C20ORF27 chromosome 20 open reading frame 27
CD160 CD160 molecule
CD22 CD22 molecule
CD84 CD84 molecule
CDC25C cell division cycle 25C
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL2A1 collagen, type II, alpha 1
COMP cartilage oligomeric matrix protein
CRISP2 cysteine-rich secretory protein 2
CRYBB1 crystallin, beta B1
DAPK2 death-associated protein kinase 2
DCBLD2 discoidin, CUB and LCCL domain containing 2
DCLK2 doublecortin-like kinase 2
DESI2 desumoylating isopeptidase 2
DSTYK dual serine/threonine and tyrosine protein kinase
EDN3 endothelin 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENG endoglin
ENOX2 ecto-NOX disulfide-thiol exchanger 2
FGFR2 fibroblast growth factor receptor 2
FSTL3 follistatin-like 3 (secreted glycoprotein)
FXYD3 FXYD domain containing ion transport regulator 3
GAS1 growth arrest-specific 1
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
GPR132 G protein-coupled receptor 132
GRM4 glutamate receptor, metabotropic 4
GSPT1 G1 to S phase transition 1
HIPK3 homeodomain interacting protein kinase 3
HLA-F major histocompatibility complex, class I, F
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IAPP islet amyloid polypeptide
IMPG1 interphotoreceptor matrix proteoglycan 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KIAA0125 KIAA0125
KIAA1109 KIAA1109
KLF5 Kruppel-like factor 5 (intestinal)
KLHL11 kelch-like family member 11
LAMA4 laminin, alpha 4
LAMB2 laminin, beta 2 (laminin S)
LIMD2 LIM domain containing 2
LMOD1 leiomodin 1 (smooth muscle)
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MAT2A methionine adenosyltransferase II, alpha
MAX MYC associated factor X
MDFI MyoD family inhibitor
MUC1 mucin 1, cell surface associated
NCOR2 nuclear receptor corepressor 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NMT1 N-myristoyltransferase 1
OGFR opioid growth factor receptor
ONECUT2 one cut homeobox 2
OR52A1 olfactory receptor, family 52, subfamily A, member 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PDE4A phosphodiesterase 4A, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
POU1F1 POU class 1 homeobox 1
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRKCI protein kinase C, iota
PRR16 proline rich 16
RNF6 ring finger protein (C3H2C3 type) 6
SAA3P serum amyloid A3 pseudogene
SCGB2A1 secretoglobin, family 2A, member 1
SCIN scinderin
SEMG2 semenogelin II
SERHL2 serine hydrolase-like 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPATS2L spermatogenesis associated, serine-rich 2-like
SRPK3 SRSF protein kinase 3
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STK3 serine/threonine kinase 3
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TEAD3 TEA domain family member 3
TLK1 tousled-like kinase 1
TPM3 tropomyosin 3
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TRPS1 trichorhinophalangeal syndrome I
TSPY1 testis specific protein, Y-linked 1
VAMP5 vesicle-associated membrane protein 5
WDR78 WD repeat domain 78
WIPI2 WD repeat domain, phosphoinositide interacting 2
WISP3 WNT1 inducible signaling pathway protein 3
ZFX zinc finger protein, X-linked
ZNF440 zinc finger protein 440

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADGB androglobin
ADGRE1 adhesion G protein-coupled receptor E1
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
ANKRD55 ankyrin repeat domain 55
ANO2 anoctamin 2, calcium activated chloride channel
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARG1 arginase 1
BHMT2 betaine--homocysteine S-methyltransferase 2
BIRC3 baculoviral IAP repeat containing 3
BTF3P11 basic transcription factor 3 pseudogene 11
C11ORF30 chromosome 11 open reading frame 30
C11ORF63 chromosome 11 open reading frame 63
C14ORF93 chromosome 14 open reading frame 93
C17ORF53 chromosome 17 open reading frame 53
C3ORF14 chromosome 3 open reading frame 14
C3ORF18 chromosome 3 open reading frame 18
C6ORF10 chromosome 6 open reading frame 10
CFAP45 cilia and flagella associated protein 45
CLGN calmegin
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
COQ6 coenzyme Q6 monooxygenase
CXCL2 chemokine (C-X-C motif) ligand 2
DUSP4 dual specificity phosphatase 4
FAM205BP transmembrane protein C9orf144B pseudogene
FBXO40 F-box protein 40
GATA4 GATA binding protein 4
GBP2 guanylate binding protein 2, interferon-inducible
GIF gastric intrinsic factor (vitamin B synthesis)
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPR35 G protein-coupled receptor 35
GRPR gastrin-releasing peptide receptor
GSTA3 glutathione S-transferase alpha 3
HCG4 HLA complex group 4 (non-protein coding)
HDAC7 histone deacetylase 7
HIST1H3I histone cluster 1, H3i
HOXA5 homeobox A5
HOXC10 homeobox C10
HOXC8 homeobox C8
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KLK11 kallikrein-related peptidase 11
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC100286895 cell division cycle 27 homolog pseudogene
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MMP9 matrix metallopeptidase 9
MYBPC1 myosin binding protein C, slow type
MYBPH myosin binding protein H
MYO15A myosin XVA
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEUROD1 neuronal differentiation 1
NFE2L3 nuclear factor, erythroid 2-like 3
NMUR1 neuromedin U receptor 1
NOD1 nucleotide-binding oligomerization domain containing 1
NOL10 nucleolar protein 10
NPM3 nucleophosmin/nucleoplasmin 3
PCDHGB6 protocadherin gamma subfamily B, 6
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PIPOX pipecolic acid oxidase
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLEKHS1 pleckstrin homology domain containing, family S member 1
POLH polymerase (DNA directed), eta
POM121L2 POM121 transmembrane nucleoporin-like 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
QSER1 glutamine and serine rich 1
RAB33A RAB33A, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCN5A sodium channel, voltage gated, type V alpha subunit
SH2D4A SH2 domain containing 4A
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC17A2 solute carrier family 17, member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNTA1 syntrophin, alpha 1
SPTBN5 spectrin, beta, non-erythrocytic 5
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SYNDIG1 synapse differentiation inducing 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TFDP3 transcription factor Dp family, member 3
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM140 transmembrane protein 140
TMEM187 transmembrane protein 187
TPSB2 tryptase beta 2 (gene/pseudogene)
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TSPAN2 tetraspanin 2
TTC23 tetratricopeptide repeat domain 23
UNC13B unc-13 homolog B (C. elegans)
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
ZFHX3 zinc finger homeobox 3
ZNF10 zinc finger protein 10
ZNF155 zinc finger protein 155
ZNF280A zinc finger protein 280A
ZNF747 zinc finger protein 747