tolfenamic acid-6354 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the tolfenamic acid-6354 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
APOLD1 apolipoprotein L domain containing 1
ARHGAP1 Rho GTPase activating protein 1
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ATP10B ATPase, class V, type 10B
BDKRB1 bradykinin receptor B1
C1QL1 complement component 1, q subcomponent-like 1
CCDC132 coiled-coil domain containing 132
CCDC40 coiled-coil domain containing 40
CD3D CD3d molecule, delta (CD3-TCR complex)
CD82 CD82 molecule
CD8B CD8b molecule
CDRT1 CMT1A duplicated region transcript 1
CEP250 centrosomal protein 250kDa
CFAP45 cilia and flagella associated protein 45
CIB2 calcium and integrin binding family member 2
CISH cytokine inducible SH2-containing protein
CLIC5 chloride intracellular channel 5
CLTB clathrin, light chain B
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CREB3L1 cAMP responsive element binding protein 3-like 1
CSF1 colony stimulating factor 1 (macrophage)
CTNND2 catenin (cadherin-associated protein), delta 2
CTNS cystinosin, lysosomal cystine transporter
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DGKE diacylglycerol kinase, epsilon 64kDa
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAAF1 dynein, axonemal, assembly factor 1
ELMO2 engulfment and cell motility 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FADS3 fatty acid desaturase 3
FAM13A family with sequence similarity 13, member A
FMOD fibromodulin
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GOLGA2 golgin A2
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GPX2 glutathione peroxidase 2
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXB2 homeobox B2
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IFFO1 intermediate filament family orphan 1
IL12RB1 interleukin 12 receptor, beta 1
INO80B INO80 complex subunit B
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KHK ketohexokinase (fructokinase)
KRT15 keratin 15, type I
KRT24 keratin 24, type I
LRP2 low density lipoprotein receptor-related protein 2
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MARK4 MAP/microtubule affinity-regulating kinase 4
MED25 mediator complex subunit 25
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MMP25 matrix metallopeptidase 25
MORN1 MORN repeat containing 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
N4BP1 NEDD4 binding protein 1
N4BP2L2 NEDD4 binding protein 2-like 2
NCAPH2 non-SMC condensin II complex, subunit H2
NF2 neurofibromin 2 (merlin)
NLGN1 neuroligin 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRF1 nuclear respiratory factor 1
NSUN6 NOP2/Sun domain family, member 6
PALM paralemmin
PDE2A phosphodiesterase 2A, cGMP-stimulated
PLD2 phospholipase D2
PQBP1 polyglutamine binding protein 1
PTCD1 pentatricopeptide repeat domain 1
RAB36 RAB36, member RAS oncogene family
REST RE1-silencing transcription factor
RIN3 Ras and Rab interactor 3
RPL10L ribosomal protein L10-like
RPS28 ribosomal protein S28
S1PR1 sphingosine-1-phosphate receptor 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERTAD3 SERTA domain containing 3
SETD8 SET domain containing (lysine methyltransferase) 8
SGK2 serum/glucocorticoid regulated kinase 2
SLC22A14 solute carrier family 22, member 14
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAB2 stabilin 2
TACC1 transforming, acidic coiled-coil containing protein 1
TBX1 T-box 1
TBX2 T-box 2
UBOX5 U-box domain containing 5
UBQLN4 ubiquilin 4
USB1 U6 snRNA biogenesis 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZNF428 zinc finger protein 428

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ABHD8 abhydrolase domain containing 8
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADGRG2 adhesion G protein-coupled receptor G2
AFAP1 actin filament associated protein 1
ANXA2P3 annexin A2 pseudogene 3
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGAP12 Rho GTPase activating protein 12
BATF3 basic leucine zipper transcription factor, ATF-like 3
BBS7 Bardet-Biedl syndrome 7
BEX1 brain expressed, X-linked 1
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF63 chromosome 11 open reading frame 63
C11ORF80 chromosome 11 open reading frame 80
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHML choroideremia-like (Rab escort protein 2)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLEC2B C-type lectin domain family 2, member B
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CORO2A coronin, actin binding protein, 2A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRNP3 cysteine-serine-rich nuclear protein 3
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
EFCAB2 EF-hand calcium binding domain 2
EGF epidermal growth factor
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPHA4 EPH receptor A4
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EXOC5 exocyst complex component 5
FADS2 fatty acid desaturase 2
FAM169A family with sequence similarity 169, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXL7 F-box and leucine-rich repeat protein 7
FCGRT Fc fragment of IgG, receptor, transporter, alpha
GMPPB GDP-mannose pyrophosphorylase B
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GTF2I general transcription factor IIi
HDAC5 histone deacetylase 5
HHLA3 HERV-H LTR-associating 3
HOXA4 homeobox A4
HOXC5 homeobox C5
IL4R interleukin 4 receptor
IREB2 iron-responsive element binding protein 2
ISYNA1 inositol-3-phosphate synthase 1
LAMB2 laminin, beta 2 (laminin S)
LMBR1L limb development membrane protein 1-like
LRRC37A3 leucine rich repeat containing 37, member A3
LRRK1 leucine-rich repeat kinase 1
LYPD1 LY6/PLAUR domain containing 1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MOGS mannosyl-oligosaccharide glucosidase
MPI mannose phosphate isomerase
MTG1 mitochondrial ribosome-associated GTPase 1
MYL5 myosin, light chain 5, regulatory
NDRG4 NDRG family member 4
NXPE3 neurexophilin and PC-esterase domain family, member 3
OLFML2A olfactomedin-like 2A
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PARP16 poly (ADP-ribose) polymerase family, member 16
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDZD2 PDZ domain containing 2
PECR peroxisomal trans-2-enoyl-CoA reductase
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLH polymerase (DNA directed), eta
POMT2 protein-O-mannosyltransferase 2
POTEKP POTE ankyrin domain family, member K, pseudogene
PRPH peripherin
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RIBC2 RIB43A domain with coiled-coils 2
SCAMP5 secretory carrier membrane protein 5
SESN1 sestrin 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC12A9 solute carrier family 12, member 9
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC46A3 solute carrier family 46, member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLMO1 slowmo homolog 1 (Drosophila)
SREK1IP1 SREK1-interacting protein 1
STAC SH3 and cysteine rich domain
SYTL2 synaptotagmin-like 2
TCTN1 tectonic family member 1
TMEM209 transmembrane protein 209
TNS2 tensin 2
TPK1 thiamin pyrophosphokinase 1
TSPAN1 tetraspanin 1
TTC26 tetratricopeptide repeat domain 26
WDR18 WD repeat domain 18
WDR37 WD repeat domain 37
ZFHX3 zinc finger homeobox 3
ZNF571 zinc finger protein 571