tolfenamic acid-2120 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the tolfenamic acid-2120 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACAN aggrecan
ADGRE2 adhesion G protein-coupled receptor E2
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANGPTL4 angiopoietin-like 4
ANP32A-IT1 ANP32A intronic transcript 1
ANTXR1 anthrax toxin receptor 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATF6B activating transcription factor 6 beta
BAIAP3 BAI1-associated protein 3
BAX BCL2-associated X protein
BBS9 Bardet-Biedl syndrome 9
BEGAIN brain-enriched guanylate kinase-associated
BMP4 bone morphogenetic protein 4
C19ORF40 chromosome 19 open reading frame 40
CCDC28B coiled-coil domain containing 28B
CD22 CD22 molecule
CD33 CD33 molecule
CDK20 cyclin-dependent kinase 20
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
COL9A2 collagen, type IX, alpha 2
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CST4 cystatin S
CTNND2 catenin (cadherin-associated protein), delta 2
DOK4 docking protein 4
EFNA3 ephrin-A3
ELSPBP1 epididymal sperm binding protein 1
EXD3 exonuclease 3'-5' domain containing 3
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GBP2 guanylate binding protein 2, interferon-inducible
HIST1H2BJ histone cluster 1, H2bj
HIST1H4A histone cluster 1, H4a
HPS1 Hermansky-Pudlak syndrome 1
IFI30 interferon, gamma-inducible protein 30
IFI44L interferon-induced protein 44-like
ITGB7 integrin, beta 7
JUN jun proto-oncogene
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
LDB1 LIM domain binding 1
LIPE lipase, hormone-sensitive
LYPD3 LY6/PLAUR domain containing 3
MAPT microtubule-associated protein tau
MARCKS myristoylated alanine-rich protein kinase C substrate
METTL7A methyltransferase like 7A
MGC2889 uncharacterized protein MGC2889
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MXD4 MAX dimerization protein 4
MYOZ1 myozenin 1
NCAPH2 non-SMC condensin II complex, subunit H2
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDGFB platelet-derived growth factor beta polypeptide
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PEX11A peroxisomal biogenesis factor 11 alpha
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PPIA peptidylprolyl isomerase A (cyclophilin A)
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB28 RAB28, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
REST RE1-silencing transcription factor
RGS10 regulator of G-protein signaling 10
RGS4 regulator of G-protein signaling 4
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RPH3AL rabphilin 3A-like (without C2 domains)
RPL10 ribosomal protein L10
SCAND2P SCAN domain containing 2 pseudogene
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMAD1 SMAD family member 1
SNCG synuclein, gamma (breast cancer-specific protein 1)
SORBS1 sorbin and SH3 domain containing 1
SPHK2 sphingosine kinase 2
SPINK5 serine peptidase inhibitor, Kazal type 5
SSX3 synovial sarcoma, X breakpoint 3
STS steroid sulfatase (microsomal), isozyme S
SYNGR3 synaptogyrin 3
TAOK1 TAO kinase 1
TBKBP1 TBK1 binding protein 1
TBX2 T-box 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UNC13A unc-13 homolog A (C. elegans)
UNC45A unc-45 homolog A (C. elegans)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
YY2 YY2 transcription factor
ZNF428 zinc finger protein 428
ZNF442 zinc finger protein 442

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
APOLD1 apolipoprotein L domain containing 1
ARRB2 arrestin, beta 2
ASB8 ankyrin repeat and SOCS box containing 8
BAK1 BCL2-antagonist/killer 1
BCL2L2 BCL2-like 2
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1
C1ORF105 chromosome 1 open reading frame 105
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLK2 CDC-like kinase 2
CXORF56 chromosome X open reading frame 56
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DTWD1 DTW domain containing 1
EDN1 endothelin 1
EHF ets homologous factor
EVPL envoplakin
F3 coagulation factor III (thromboplastin, tissue factor)
FAM160B2 family with sequence similarity 160, member B2
FAM53B family with sequence similarity 53, member B
FAM57A family with sequence similarity 57, member A
FBXL7 F-box and leucine-rich repeat protein 7
FKBP10 FK506 binding protein 10, 65 kDa
FLRT3 fibronectin leucine rich transmembrane protein 3
GPATCH2L G patch domain containing 2-like
GRWD1 glutamate-rich WD repeat containing 1
H1F0 H1 histone family, member 0
HIRIP3 HIRA interacting protein 3
HSF2BP heat shock transcription factor 2 binding protein
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL17RB interleukin 17 receptor B
IRF7 interferon regulatory factor 7
JAM3 junctional adhesion molecule 3
JUNB jun B proto-oncogene
KDM7A lysine (K)-specific demethylase 7A
LIG4 ligase IV, DNA, ATP-dependent
LOC100272216 uncharacterized LOC100272216
LUC7L LUC7-like (S. cerevisiae)
MAGEH1 melanoma antigen family H1
MANSC1 MANSC domain containing 1
MPDZ multiple PDZ domain protein
NABP2 nucleic acid binding protein 2
NAP1L3 nucleosome assembly protein 1-like 3
NPFFR1 neuropeptide FF receptor 1
NPM3 nucleophosmin/nucleoplasmin 3
OLFML2A olfactomedin-like 2A
ORC1 origin recognition complex, subunit 1
OSR2 odd-skipped related transciption factor 2
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDLIM2 PDZ and LIM domain 2 (mystique)
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLK2 polo-like kinase 2
PLSCR4 phospholipid scramblase 4
PNRC1 proline-rich nuclear receptor coactivator 1
POMT2 protein-O-mannosyltransferase 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTBP2 polypyrimidine tract binding protein 2
PTCD1 pentatricopeptide repeat domain 1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
PVRL3 poliovirus receptor-related 3
RAB3A RAB3A, member RAS oncogene family
RBL1 retinoblastoma-like 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF111 ring finger protein 111
RPE ribulose-5-phosphate-3-epimerase
RPGR retinitis pigmentosa GTPase regulator
SAMHD1 SAM domain and HD domain 1
SH3BGR SH3 domain binding glutamate-rich protein
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNTA1 syntrophin, alpha 1
SNX24 sorting nexin 24
SP140L SP140 nuclear body protein-like
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TESK2 testis-specific kinase 2
THBS3 thrombospondin 3
TMEM2 transmembrane protein 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM5 tripartite motif containing 5
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TWISTNB TWIST neighbor
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR60 WD repeat domain 60
YAF2 YY1 associated factor 2
ZBTB10 zinc finger and BTB domain containing 10
ZBTB3 zinc finger and BTB domain containing 3
ZNF215 zinc finger protein 215
ZNF551 zinc finger protein 551
ZNF767P zinc finger family member 767, pseudogene
ZNF804A zinc finger protein 804A
ZW10 zw10 kinetochore protein