tolfenamic acid-1437 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the tolfenamic acid-1437 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARHGAP1 Rho GTPase activating protein 1
ATG4B autophagy related 4B, cysteine peptidase
ATN1 atrophin 1
BCL6 B-cell CLL/lymphoma 6
BMP15 bone morphogenetic protein 15
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
CA5BP1 carbonic anhydrase VB pseudogene 1
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCDC64 coiled-coil domain containing 64
CD151 CD151 molecule (Raph blood group)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL5A3 collagen, type V, alpha 3
COPS2 COP9 signalosome subunit 2
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
EGR4 early growth response 4
FOS FBJ murine osteosarcoma viral oncogene homolog
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GFOD2 glucose-fructose oxidoreductase domain containing 2
GLRA2 glycine receptor, alpha 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPR107 G protein-coupled receptor 107
GPR27 G protein-coupled receptor 27
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRB7 growth factor receptor-bound protein 7
HFE hemochromatosis
HIST1H1D histone cluster 1, H1d
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTRA1 HtrA serine peptidase 1
IL27RA interleukin 27 receptor, alpha
IPW imprinted in Prader-Willi syndrome (non-protein coding)
IQCK IQ motif containing K
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KIAA1045 KIAA1045
KLF6 Kruppel-like factor 6
LAD1 ladinin 1
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LPPR3 lipid phosphate phosphatase-related protein type 3
LYZL6 lysozyme-like 6
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP2K6 mitogen-activated protein kinase kinase 6
MED16 mediator complex subunit 16
MED18 mediator complex subunit 18
MEF2C myocyte enhancer factor 2C
MICALL2 MICAL-like 2
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MPDU1 mannose-P-dolichol utilization defect 1
MYL10 myosin, light chain 10, regulatory
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NADK NAD kinase
NOL12 nucleolar protein 12
OCRL oculocerebrorenal syndrome of Lowe
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
ORC3 origin recognition complex, subunit 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLK4 polo-like kinase 4
PNPLA4 patatin-like phospholipase domain containing 4
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PXDN peroxidasin
RAB30 RAB30, member RAS oncogene family
RAD51D RAD51 paralog D
RHOD ras homolog family member D
RHOH ras homolog family member H
RNF39 ring finger protein 39
RPS14 ribosomal protein S14
SFTPC surfactant protein C
SLC17A4 solute carrier family 17, member 4
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SORT1 sortilin 1
SP140L SP140 nuclear body protein-like
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
STAC SH3 and cysteine rich domain
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TCAF1 TRPM8 channel-associated factor 1
TCF20 transcription factor 20 (AR1)
TCF3 transcription factor 3
TCL1A T-cell leukemia/lymphoma 1A
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TK2 thymidine kinase 2, mitochondrial
TM7SF2 transmembrane 7 superfamily member 2
TMEM74B transmembrane protein 74B
TMEM97 transmembrane protein 97
TMPRSS6 transmembrane protease, serine 6
TRIB2 tribbles pseudokinase 2
TSPYL2 TSPY-like 2
VARS valyl-tRNA synthetase
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF236 zinc finger protein 236
ZNF337 zinc finger protein 337
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
AHR aryl hydrocarbon receptor
ANPEP alanyl (membrane) aminopeptidase
AP1B1 adaptor-related protein complex 1, beta 1 subunit
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
ASCC2 activating signal cointegrator 1 complex subunit 2
ATAT1 alpha tubulin acetyltransferase 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
AZI2 5-azacytidine induced 2
BANP BTG3 associated nuclear protein
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2
BRIX1 BRX1, biogenesis of ribosomes
C5ORF28 chromosome 5 open reading frame 28
CASZ1 castor zinc finger 1
CCDC6 coiled-coil domain containing 6
CDC37L1 cell division cycle 37-like 1
CENPT centromere protein T
CFAP74 cilia and flagella associated protein 74
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHSY1 chondroitin sulfate synthase 1
CLTCL1 clathrin, heavy chain-like 1
CMTR1 cap methyltransferase 1
CRYBG3 beta-gamma crystallin domain containing 3
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DENND4A DENN/MADD domain containing 4A
DMXL1 Dmx-like 1
EP300 E1A binding protein p300
EPM2AIP1 EPM2A (laforin) interacting protein 1
ERO1L ERO1-like (S. cerevisiae)
FANCF Fanconi anemia, complementation group F
FKBP2 FK506 binding protein 2, 13kDa
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GOLM1 golgi membrane protein 1
GRPR gastrin-releasing peptide receptor
GRWD1 glutamate-rich WD repeat containing 1
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUSBP3 glucuronidase, beta pseudogene 3
HOMER1 homer scaffolding protein 1
KCTD3 potassium channel tetramerization domain containing 3
KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1
KLHL21 kelch-like family member 21
KPTN kaptin (actin binding protein)
LOC642236 FSHD region gene 1 pseudogene
MAGOHB mago-nashi homolog B (Drosophila)
MAGT1 magnesium transporter 1
MAPK10 mitogen-activated protein kinase 10
MCTP1 multiple C2 domains, transmembrane 1
MEX3C mex-3 RNA binding family member C
MORC3 MORC family CW-type zinc finger 3
NIP7 NIP7, nucleolar pre-rRNA processing protein
NUCB2 nucleobindin 2
NXPH3 neurexophilin 3
ORC6 origin recognition complex, subunit 6
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCNXL4 pecanex-like 4 (Drosophila)
PCSK7 proprotein convertase subtilisin/kexin type 7
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G12A phospholipase A2, group XIIA
PNRC1 proline-rich nuclear receptor coactivator 1
PRKX protein kinase, X-linked
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RBMS3 RNA binding motif, single stranded interacting protein 3
RECQL4 RecQ protein-like 4
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPL26 ribosomal protein L26
RPS4Y1 ribosomal protein S4, Y-linked 1
RUFY2 RUN and FYVE domain containing 2
RWDD3 RWD domain containing 3
SETD1B SET domain containing 1B
SETD8 SET domain containing (lysine methyltransferase) 8
SETMAR SET domain and mariner transposase fusion gene
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLMO2 slowmo homolog 2 (Drosophila)
SNX10 sorting nexin 10
SNX15 sorting nexin 15
SPC25 SPC25, NDC80 kinetochore complex component
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STK25 serine/threonine kinase 25
TMEM104 transmembrane protein 104
TMEM80 transmembrane protein 80
TRAC T cell receptor alpha constant
TRAPPC11 trafficking protein particle complex 11
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSSC4 tumor suppressing subtransferable candidate 4
TTF2 transcription termination factor, RNA polymerase II
UNC93B1 unc-93 homolog B1 (C. elegans)
WDR11 WD repeat domain 11
WT1-AS WT1 antisense RNA
XYLT1 xylosyltransferase I
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZCCHC10 zinc finger, CCHC domain containing 10
ZNF160 zinc finger protein 160