tolbutamide-4540 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the tolbutamide-4540 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACOT11 acyl-CoA thioesterase 11
ACRV1 acrosomal vesicle protein 1
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADPRH ADP-ribosylarginine hydrolase
AKR1C2 aldo-keto reductase family 1, member C2
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2 B-cell CLL/lymphoma 2
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CCDC71 coiled-coil domain containing 71
CCNO cyclin O
CDK10 cyclin-dependent kinase 10
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CISH cytokine inducible SH2-containing protein
COL10A1 collagen, type X, alpha 1
COL6A1 collagen, type VI, alpha 1
CUL5 cullin 5
CYTH1 cytohesin 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOHH deoxyhypusine hydroxylase/monooxygenase
DPF1 D4, zinc and double PHD fingers family 1
ELAC2 elaC ribonuclease Z 2
EMC3 ER membrane protein complex subunit 3
EML3 echinoderm microtubule associated protein like 3
EPS8L1 EPS8-like 1
ETV6 ets variant 6
FAM110B family with sequence similarity 110, member B
FBXO31 F-box protein 31
FGF5 fibroblast growth factor 5
FH fumarate hydratase
FHIT fragile histidine triad
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GYG2 glycogenin 2
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
IFNA14 interferon, alpha 14
IL36RN interleukin 36 receptor antagonist
ING4 inhibitor of growth family, member 4
INO80D INO80 complex subunit D
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IQCK IQ motif containing K
KAT2A K(lysine) acetyltransferase 2A
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
LAMC3 laminin, gamma 3
LEF1 lymphoid enhancer-binding factor 1
LEPROT leptin receptor overlapping transcript
LINC00115 long intergenic non-protein coding RNA 115
LIPE lipase, hormone-sensitive
LMNB1 lamin B1
LOC100287590 uncharacterized LOC100287590
LOC157562 uncharacterized LOC157562
MMP10 matrix metallopeptidase 10
MRAS muscle RAS oncogene homolog
MTUS1 microtubule associated tumor suppressor 1
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NIPAL2 NIPA-like domain containing 2
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PAWR PRKC, apoptosis, WT1, regulator
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PLEK pleckstrin
PLXND1 plexin D1
PPARD peroxisome proliferator-activated receptor delta
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRY PTPN13-like, Y-linked
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAD51 RAD51 recombinase
RARB retinoic acid receptor, beta
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RBMS2 RNA binding motif, single stranded interacting protein 2
RGS5 regulator of G-protein signaling 5
RNF6 ring finger protein (C3H2C3 type) 6
RNGTT RNA guanylyltransferase and 5'-phosphatase
RRH retinal pigment epithelium-derived rhodopsin homolog
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SCARB1 scavenger receptor class B, member 1
SETD8 SET domain containing (lysine methyltransferase) 8
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SOS2 son of sevenless homolog 2 (Drosophila)
SP1 Sp1 transcription factor
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPRR2B small proline-rich protein 2B
SULT4A1 sulfotransferase family 4A, member 1
TACR1 tachykinin receptor 1
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TMPRSS2 transmembrane protease, serine 2
TRIM2 tripartite motif containing 2
TUBA3C tubulin, alpha 3c
TXK TXK tyrosine kinase
WFDC2 WAP four-disulfide core domain 2
ZCCHC4 zinc finger, CCHC domain containing 4
ZNF219 zinc finger protein 219
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADAM2 ADAM metallopeptidase domain 2
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARMC6 armadillo repeat containing 6
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAT1 alpha tubulin acetyltransferase 1
AXIN1 axin 1
BAAT bile acid CoA:amino acid N-acyltransferase
BAHD1 bromo adjacent homology domain containing 1
C3 complement component 3
C5ORF45 chromosome 5 open reading frame 45
C7ORF43 chromosome 7 open reading frame 43
CCDC85C coiled-coil domain containing 85C
CD101 CD101 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDH7 cadherin 7, type 2
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CXCL3 chemokine (C-X-C motif) ligand 3
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
EFNB1 ephrin-B1
EN2 engrailed homeobox 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM186A family with sequence similarity 186, member A
FBXL7 F-box and leucine-rich repeat protein 7
FHOD1 formin homology 2 domain containing 1
FKRP fukutin related protein
FMO4 flavin containing monooxygenase 4
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GJA8 gap junction protein, alpha 8, 50kDa
GPATCH3 G patch domain containing 3
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUSBP3 glucuronidase, beta pseudogene 3
HDAC5 histone deacetylase 5
HIST1H2BO histone cluster 1, H2bo
HOXA1 homeobox A1
JUNB jun B proto-oncogene
KDM5C lysine (K)-specific demethylase 5C
KLF3 Kruppel-like factor 3 (basic)
LAX1 lymphocyte transmembrane adaptor 1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC390998 ribosomal protein L10 pseudogene
LOC729164 hCG1732469
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC37A3 leucine rich repeat containing 37, member A3
MAPK12 mitogen-activated protein kinase 12
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MFGE8 milk fat globule-EGF factor 8 protein
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MTHFSD methenyltetrahydrofolate synthetase domain containing
MX1 MX dynamin-like GTPase 1
MXRA8 matrix-remodelling associated 8
NACA2 nascent polypeptide-associated complex alpha subunit 2
NCS1 neuronal calcium sensor 1
NOL12 nucleolar protein 12
NUP62CL nucleoporin 62kDa C-terminal like
ODF2 outer dense fiber of sperm tails 2
OLFML3 olfactomedin-like 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDZK1 PDZ domain containing 1
PHKG2 phosphorylase kinase, gamma 2 (testis)
PID1 phosphotyrosine interaction domain containing 1
PLA2G1B phospholipase A2, group IB (pancreas)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PORCN porcupine homolog (Drosophila)
PRICKLE3 prickle homolog 3 (Drosophila)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIBC2 RIB43A domain with coiled-coils 2
RNF122 ring finger protein 122
RUNDC3B RUN domain containing 3B
SCGB2A2 secretoglobin, family 2A, member 2
SETD1A SET domain containing 1A
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STARD13 StAR-related lipid transfer (START) domain containing 13
SYNPO synaptopodin
TCTN2 tectonic family member 2
TMEM209 transmembrane protein 209
TMEM53 transmembrane protein 53
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TPCN1 two pore segment channel 1
TRAIP TRAF interacting protein
WDR33 WD repeat domain 33
WNT10B wingless-type MMTV integration site family, member 10B
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
YEATS2 YEATS domain containing 2
ZFHX3 zinc finger homeobox 3
ZFP30 ZFP30 zinc finger protein
ZNF510 zinc finger protein 510
ZNF669 zinc finger protein 669
ZNF816 zinc finger protein 816