tolbutamide-2320 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the tolbutamide-2320 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRB1 adhesion G protein-coupled receptor B1
AHNAK2 AHNAK nucleoprotein 2
AIF1 allograft inflammatory factor 1
ALDOB aldolase B, fructose-bisphosphate
AMACR alpha-methylacyl-CoA racemase
ATG10 autophagy related 10
BATF basic leucine zipper transcription factor, ATF-like
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BCO1 beta-carotene oxygenase 1
CCL19 chemokine (C-C motif) ligand 19
CD1C CD1c molecule
CDO1 cysteine dioxygenase type 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFLAR CASP8 and FADD-like apoptosis regulator
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CNR2 cannabinoid receptor 2 (macrophage)
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL5A2 collagen, type V, alpha 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
ERP44 endoplasmic reticulum protein 44
ESR2 estrogen receptor 2 (ER beta)
FANCA Fanconi anemia, complementation group A
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FGFR1 fibroblast growth factor receptor 1
GYG2 glycogenin 2
HPS1 Hermansky-Pudlak syndrome 1
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
ICOSLG inducible T-cell co-stimulator ligand
IFI35 interferon-induced protein 35
IL2RB interleukin 2 receptor, beta
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF4 interferon regulatory factor 4
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KHSRP KH-type splicing regulatory protein
KPNA5 karyopherin alpha 5 (importin alpha 6)
KREMEN2 kringle containing transmembrane protein 2
KRT83 keratin 83, type II
LINC00216 long intergenic non-protein coding RNA 216
LMF2 lipase maturation factor 2
LOXL3 lysyl oxidase-like 3
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MBNL3 muscleblind-like splicing regulator 3
MDFI MyoD family inhibitor
MED16 mediator complex subunit 16
MFSD6 major facilitator superfamily domain containing 6
MMP11 matrix metallopeptidase 11
MST1L macrophage stimulating 1-like
MTMR3 myotubularin related protein 3
MYOZ1 myozenin 1
NCR1 natural cytotoxicity triggering receptor 1
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NEUROD4 neuronal differentiation 4
NUP54 nucleoporin 54kDa
ONECUT2 one cut homeobox 2
OR3A3 olfactory receptor, family 3, subfamily A, member 3
OSBP2 oxysterol binding protein 2
OSBPL10 oxysterol binding protein-like 10
PAX5 paired box 5
PDE4C phosphodiesterase 4C, cAMP-specific
PENK proenkephalin
PGLYRP4 peptidoglycan recognition protein 4
PLAT plasminogen activator, tissue
PRSS3 protease, serine, 3
PYHIN1 pyrin and HIN domain family, member 1
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RASL11B RAS-like, family 11, member B
RPS3A ribosomal protein S3A
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A13 S100 calcium binding protein A13
SDC3 syndecan 3
SLC17A2 solute carrier family 17, member 2
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SMG7-AS1 SMG7 antisense RNA 1
SPARCL1 SPARC-like 1 (hevin)
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBC1D2 TBC1 domain family, member 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TLN1 talin 1
TMEM246 transmembrane protein 246
TTC38 tetratricopeptide repeat domain 38
UHRF1BP1L UHRF1 binding protein 1-like
WDR62 WD repeat domain 62
WSB1 WD repeat and SOCS box containing 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZC3H7B zinc finger CCCH-type containing 7B
ZFP64 ZFP64 zinc finger protein
ZNF518A zinc finger protein 518A
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADGRG2 adhesion G protein-coupled receptor G2
AFAP1 actin filament associated protein 1
AMPD1 adenosine monophosphate deaminase 1
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
AUTS2 autism susceptibility candidate 2
BAHCC1 BAH domain and coiled-coil containing 1
BCORL1 BCL6 corepressor-like 1
BMP10 bone morphogenetic protein 10
BMP4 bone morphogenetic protein 4
C19ORF73 chromosome 19 open reading frame 73
C1ORF105 chromosome 1 open reading frame 105
C1ORF56 chromosome 1 open reading frame 56
C1QTNF3 C1q and tumor necrosis factor related protein 3
CA5BP1 carbonic anhydrase VB pseudogene 1
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CD83 CD83 molecule
CDK18 cyclin-dependent kinase 18
CDK3 cyclin-dependent kinase 3
CLCN5 chloride channel, voltage-sensitive 5
CLCN6 chloride channel, voltage-sensitive 6
CRELD1 cysteine-rich with EGF-like domains 1
CUL9 cullin 9
DEFA4 defensin, alpha 4, corticostatin
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DPF2 D4, zinc and double PHD fingers family 2
DUSP2 dual specificity phosphatase 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDAR ectodysplasin A receptor
ERN2 endoplasmic reticulum to nucleus signaling 2
ESRP2 epithelial splicing regulatory protein 2
FAM50B family with sequence similarity 50, member B
FBXL2 F-box and leucine-rich repeat protein 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLCN folliculin
FRK fyn-related Src family tyrosine kinase
GFI1 growth factor independent 1 transcription repressor
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H3B histone cluster 1, H3b
HIST1H4D histone cluster 1, H4d
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IL22 interleukin 22
JMJD4 jumonji domain containing 4
JUNB jun B proto-oncogene
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KEL Kell blood group, metallo-endopeptidase
KIAA1107 KIAA1107
LRRC37A2 leucine rich repeat containing 37, member A2
LYPD1 LY6/PLAUR domain containing 1
MAP9 microtubule-associated protein 9
MB myoglobin
MNX1 motor neuron and pancreas homeobox 1
NRGN neurogranin (protein kinase C substrate, RC3)
ORAI3 ORAI calcium release-activated calcium modulator 3
OVOL1 ovo-like zinc finger 1
PAIP2B poly(A) binding protein interacting protein 2B
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PER3 period circadian clock 3
PLEKHA6 pleckstrin homology domain containing, family A member 6
PMEL premelanosome protein
PORCN porcupine homolog (Drosophila)
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRR4 proline rich 4 (lacrimal)
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPRS protein tyrosine phosphatase, receptor type, S
RAB36 RAB36, member RAS oncogene family
RAP1GAP2 RAP1 GTPase activating protein 2
RFTN1 raftlin, lipid raft linker 1
RIN1 Ras and Rab interactor 1
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPL13P5 ribosomal protein L13 pseudogene 5
SAYSD1 SAYSVFN motif domain containing 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SOX12 SRY (sex determining region Y)-box 12
SPAG4 sperm associated antigen 4
SPINK5 serine peptidase inhibitor, Kazal type 5
SRD5A3 steroid 5 alpha-reductase 3
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TAPBP TAP binding protein (tapasin)
TBKBP1 TBK1 binding protein 1
TCTN1 tectonic family member 1
TICAM1 toll-like receptor adaptor molecule 1
TMC7 transmembrane channel-like 7
TMEM180 transmembrane protein 180
TNS2 tensin 2
TRAIP TRAF interacting protein
TUBG2 tubulin, gamma 2
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
XK X-linked Kx blood group
YIF1A Yip1 interacting factor homolog A (S. cerevisiae)
ZNF134 zinc finger protein 134
ZNF506 zinc finger protein 506
ZNF862 zinc finger protein 862