tocainide-7351 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the tocainide-7351 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ADRBK1 adrenergic, beta, receptor kinase 1
AGXT alanine-glyoxylate aminotransferase
AHI1 Abelson helper integration site 1
AKR1C1 aldo-keto reductase family 1, member C1
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
ARTN artemin
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP11A ATPase, class VI, type 11A
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BIN1 bridging integrator 1
C11ORF63 chromosome 11 open reading frame 63
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC88A coiled-coil domain containing 88A
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHKB choline kinase beta
CHM choroideremia (Rab escort protein 1)
CNR2 cannabinoid receptor 2 (macrophage)
COX4I1 cytochrome c oxidase subunit IV isoform 1
CXORF21 chromosome X open reading frame 21
DALRD3 DALR anticodon binding domain containing 3
ELL2 elongation factor, RNA polymerase II, 2
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAM214B family with sequence similarity 214, member B
FLJ11292
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GM2A GM2 ganglioside activator
GUCA2A guanylate cyclase activator 2A (guanylin)
HFE hemochromatosis
HIPK2 homeodomain interacting protein kinase 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXA6 homeobox A6
HOXB1 homeobox B1
KIAA0368 KIAA0368
KIDINS220 kinase D-interacting substrate, 220kDa
KIZ kizuna centrosomal protein
KLHL22 kelch-like family member 22
LMAN1 lectin, mannose-binding, 1
LMF2 lipase maturation factor 2
MAP1A microtubule-associated protein 1A
METTL7A methyltransferase like 7A
MFAP3L microfibrillar-associated protein 3-like
MMRN2 multimerin 2
N4BP3 NEDD4 binding protein 3
NAG18 NAG18 mRNA
NEURL1 neuralized E3 ubiquitin protein ligase 1
NEUROD4 neuronal differentiation 4
NFRKB nuclear factor related to kappaB binding protein
ORAI2 ORAI calcium release-activated calcium modulator 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHB17P protocadherin beta 17 pseudogene
PDAP1 PDGFA associated protein 1
PDE8B phosphodiesterase 8B
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PHF3 PHD finger protein 3
PICK1 protein interacting with PRKCA 1
PVR poliovirus receptor
PXN paxillin
QPCTL glutaminyl-peptide cyclotransferase-like
RAB11B RAB11B, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RAD54L2 RAD54-like 2 (S. cerevisiae)
RANBP1 RAN binding protein 1
RBM19 RNA binding motif protein 19
RECQL5 RecQ protein-like 5
REST RE1-silencing transcription factor
RGS12 regulator of G-protein signaling 12
RNF126P1 ring finger protein 126 pseudogene 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RPL23AP53 ribosomal protein L23a pseudogene 53
RPLP2 ribosomal protein, large, P2
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100A8 S100 calcium binding protein A8
SECTM1 secreted and transmembrane 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC35E2 solute carrier family 35, member E2
SLMO1 slowmo homolog 1 (Drosophila)
SOX15 SRY (sex determining region Y)-box 15
SRRM2 serine/arginine repetitive matrix 2
SSPN sarcospan
STMN1 stathmin 1
STON1 stonin 1
TBX6 T-box 6
TMEM212 transmembrane protein 212
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TPMT thiopurine S-methyltransferase
TRAK1 trafficking protein, kinesin binding 1
TRIM3 tripartite motif containing 3
TRIP11 thyroid hormone receptor interactor 11
TRPM4 transient receptor potential cation channel, subfamily M, member 4
VAC14 Vac14 homolog (S. cerevisiae)
XDH xanthine dehydrogenase
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZNF682 zinc finger protein 682
ZNF778 zinc finger protein 778
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ADCY7 adenylate cyclase 7
AIM1 absent in melanoma 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ASAP1-IT1 ASAP1 intronic transcript 1
ATAD3A ATPase family, AAA domain containing 3A
ATG2A autophagy related 2A
BAG4 BCL2-associated athanogene 4
BATF basic leucine zipper transcription factor, ATF-like
C11ORF30 chromosome 11 open reading frame 30
C14ORF93 chromosome 14 open reading frame 93
C17ORF80 chromosome 17 open reading frame 80
C19ORF40 chromosome 19 open reading frame 40
C5 complement component 5
CCDC69 coiled-coil domain containing 69
CDK3 cyclin-dependent kinase 3
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLCN2 chloride channel, voltage-sensitive 2
COQ6 coenzyme Q6 monooxygenase
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DCAF17 DDB1 and CUL4 associated factor 17
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAL4 dynein, axonemal, light chain 4
DNALI1 dynein, axonemal, light intermediate chain 1
DNMBP dynamin binding protein
DTX4 deltex 4, E3 ubiquitin ligase
DYSF dysferlin
EFNA3 ephrin-A3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ETAA1 Ewing tumor-associated antigen 1
FAAH fatty acid amide hydrolase
FAM53B family with sequence similarity 53, member B
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOSL1 FOS-like antigen 1
GBP2 guanylate binding protein 2, interferon-inducible
GLS2 glutaminase 2 (liver, mitochondrial)
GNL1 guanine nucleotide binding protein-like 1
GPC3 glypican 3
GPX2 glutathione peroxidase 2
GSTT1 glutathione S-transferase theta 1
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HMOX1 heme oxygenase 1
HSPA1L heat shock 70kDa protein 1-like
HYI hydroxypyruvate isomerase (putative)
IFI6 interferon, alpha-inducible protein 6
IL4R interleukin 4 receptor
INCENP inner centromere protein antigens 135/155kDa
IRF1 interferon regulatory factor 1
KDM5C lysine (K)-specific demethylase 5C
KIAA0125 KIAA0125
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIG4 ligase IV, DNA, ATP-dependent
LMNB1 lamin B1
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MATK megakaryocyte-associated tyrosine kinase
MRPL52 mitochondrial ribosomal protein L52
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NBEAL2 neurobeachin-like 2
NDE1 nudE neurodevelopment protein 1
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NRSN2 neurensin 2
PCDHA6 protocadherin alpha 6
PCDHB3 protocadherin beta 3
PHC1 polyhomeotic homolog 1 (Drosophila)
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RBL1 retinoblastoma-like 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RHOBTB1 Rho-related BTB domain containing 1
RNF31 ring finger protein 31
RNF39 ring finger protein 39
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SH2D4A SH2 domain containing 4A
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC39A7 solute carrier family 39 (zinc transporter), member 7
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STARD3 StAR-related lipid transfer (START) domain containing 3
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TDRD1 tudor domain containing 1
TRAF5 TNF receptor-associated factor 5
ULBP2 UL16 binding protein 2
VWA9 von Willebrand factor A domain containing 9
ZFP30 ZFP30 zinc finger protein
ZNF141 zinc finger protein 141
ZNF212 zinc finger protein 212
ZNF480 zinc finger protein 480
ZNF574 zinc finger protein 574
ZNF623 zinc finger protein 623
ZNF747 zinc finger protein 747