tocainide-4256 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the tocainide-4256 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN2 actinin, alpha 2
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALDOB aldolase B, fructose-bisphosphate
ALOXE3 arachidonate lipoxygenase 3
APOE apolipoprotein E
ASTN2 astrotactin 2
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
ATXN3L ataxin 3-like
ATXN7L1 ataxin 7-like 1
B9D1 B9 protein domain 1
BCL2 B-cell CLL/lymphoma 2
C17ORF59 chromosome 17 open reading frame 59
CCDC134 coiled-coil domain containing 134
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLIC5 chloride intracellular channel 5
CNTNAP2 contactin associated protein-like 2
CORO1B coronin, actin binding protein, 1B
CTIF CBP80/20-dependent translation initiation factor
DKFZP434L187 uncharacterized LOC26082
DPF3 D4, zinc and double PHD fingers, family 3
DRD2 dopamine receptor D2
DSG3 desmoglein 3
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
EDNRA endothelin receptor type A
ELOVL5 ELOVL fatty acid elongase 5
EXOG endo/exonuclease (5'-3'), endonuclease G-like
FAS Fas cell surface death receptor
FMO3 flavin containing monooxygenase 3
GAS7 growth arrest-specific 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GIMAP6 GTPase, IMAP family member 6
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIK5 glutamate receptor, ionotropic, kainate 5
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GZMK granzyme K (granzyme 3; tryptase II)
HFE hemochromatosis
IDS iduronate 2-sulfatase
IGHM immunoglobulin heavy constant mu
IGSF6 immunoglobulin superfamily, member 6
INO80D INO80 complex subunit D
IRAK4 interleukin-1 receptor-associated kinase 4
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCTD13 potassium channel tetramerization domain containing 13
KDM5B lysine (K)-specific demethylase 5B
KDR kinase insert domain receptor
LAG3 lymphocyte-activation gene 3
MAN2A2 mannosidase, alpha, class 2A, member 2
MIER2 mesoderm induction early response 1, family member 2
MMP3 matrix metallopeptidase 3
MST1 macrophage stimulating 1
MYH14 myosin, heavy chain 14, non-muscle
NME5 NME/NM23 family member 5
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NRTN neurturin
ORC5 origin recognition complex, subunit 5
OSBPL7 oxysterol binding protein-like 7
PAPOLG poly(A) polymerase gamma
PAPPA2 pappalysin 2
PAX5 paired box 5
PCDH11Y protocadherin 11 Y-linked
PDCD6 programmed cell death 6
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PML promyelocytic leukemia
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRDM14 PR domain containing 14
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RBFA ribosome binding factor A (putative)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RET ret proto-oncogene
RGS5 regulator of G-protein signaling 5
RHEB Ras homolog enriched in brain
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RUNX1 runt-related transcription factor 1
SLCO5A1 solute carrier organic anion transporter family, member 5A1
SMG6 SMG6 nonsense mediated mRNA decay factor
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SPRYD7 SPRY domain containing 7
SRPK3 SRSF protein kinase 3
SUGP1 SURP and G patch domain containing 1
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
TBXA2R thromboxane A2 receptor
TDRKH tudor and KH domain containing
TEX13A testis expressed 13A
TRAF3IP3 TRAF3 interacting protein 3
TUBA3C tubulin, alpha 3c
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
YIPF4 Yip1 domain family, member 4
ZFAND5 zinc finger, AN1-type domain 5
ZNF155 zinc finger protein 155
ZNF219 zinc finger protein 219
ZNF391 zinc finger protein 391
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ANGPT4 angiopoietin 4
ARHGAP24 Rho GTPase activating protein 24
ARPIN actin-related protein 2/3 complex inhibitor
ASPHD1 aspartate beta-hydroxylase domain containing 1
C22ORF29 chromosome 22 open reading frame 29
CA9 carbonic anhydrase IX
CABP2 calcium binding protein 2
CAMKMT calmodulin-lysine N-methyltransferase
CCDC186 coiled-coil domain containing 186
CCNO cyclin O
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDH10 cadherin 10, type 2 (T2-cadherin)
CELP carboxyl ester lipase pseudogene
CES3 carboxylesterase 3
CLEC10A C-type lectin domain family 10, member A
CNGB3 cyclic nucleotide gated channel beta 3
CNN1 calponin 1, basic, smooth muscle
COMP cartilage oligomeric matrix protein
CRLF1 cytokine receptor-like factor 1
CXCR2 chemokine (C-X-C motif) receptor 2
DBF4B DBF4 zinc finger B
EGLN3 egl-9 family hypoxia-inducible factor 3
EGOT eosinophil granule ontogeny transcript (non-protein coding)
ERCC4 excision repair cross-complementation group 4
ERO1LB ERO1-like beta (S. cerevisiae)
EYA3 EYA transcriptional coactivator and phosphatase 3
FA2H fatty acid 2-hydroxylase
FAM13C family with sequence similarity 13, member C
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXO40 F-box protein 40
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FRS3 fibroblast growth factor receptor substrate 3
FURIN furin (paired basic amino acid cleaving enzyme)
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GREB1L growth regulation by estrogen in breast cancer-like
GRM4 glutamate receptor, metabotropic 4
HAL histidine ammonia-lyase
HIST1H2BO histone cluster 1, H2bo
HIST1H4E histone cluster 1, H4e
HPR haptoglobin-related protein
IGKV3-20 immunoglobulin kappa variable 3-20
IL17RB interleukin 17 receptor B
ITPKA inositol-trisphosphate 3-kinase A
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIF13A kinesin family member 13A
KLF1 Kruppel-like factor 1 (erythroid)
LENEP lens epithelial protein
LIME1 Lck interacting transmembrane adaptor 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC257152 uncharacterized LOC257152
LOC729164 hCG1732469
LPAR4 lysophosphatidic acid receptor 4
MAK male germ cell-associated kinase
MBTPS2 membrane-bound transcription factor peptidase, site 2
MGP matrix Gla protein
MRPL41 mitochondrial ribosomal protein L41
MTSS1L metastasis suppressor 1-like
MUC3A mucin 3A, cell surface associated
MYOZ3 myozenin 3
NDP Norrie disease (pseudoglioma)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
OLFML2B olfactomedin-like 2B
OR12D3 olfactory receptor, family 12, subfamily D, member 3
PALM paralemmin
PARP11 poly (ADP-ribose) polymerase family, member 11
PARP6 poly (ADP-ribose) polymerase family, member 6
PCDH12 protocadherin 12
PGM5 phosphoglucomutase 5
PLAC8 placenta-specific 8
PLBD1 phospholipase B domain containing 1
PMP2 peripheral myelin protein 2
POU6F2 POU class 6 homeobox 2
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPL periplakin
PRB3 proline-rich protein BstNI subfamily 3
PRKG2 protein kinase, cGMP-dependent, type II
PRM2 protamine 2
PROL1 proline rich, lacrimal 1
PRSS50 protease, serine, 50
PRSS53 protease, serine, 53
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
RNF2 ring finger protein 2
SCD5 stearoyl-CoA desaturase 5
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERGEF secretion regulating guanine nucleotide exchange factor
SOX21 SRY (sex determining region Y)-box 21
SSBP3 single stranded DNA binding protein 3
STEAP4 STEAP family member 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TCP11 t-complex 11, testis-specific
TESPA1 thymocyte expressed, positive selection associated 1
TLR4 toll-like receptor 4
WNT1 wingless-type MMTV integration site family, member 1
ZNF510 zinc finger protein 510
ZNF76 zinc finger protein 76