tobramycin-4081 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the tobramycin-4081 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACAN aggrecan
ADCK2 aarF domain containing kinase 2
ADCY10 adenylate cyclase 10 (soluble)
AIM1L absent in melanoma 1-like
ANGPT1 angiopoietin 1
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARMC4 armadillo repeat containing 4
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
B9D1 B9 protein domain 1
C14ORF79 chromosome 14 open reading frame 79
C3 complement component 3
CA14 carbonic anhydrase XIV
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCDC121 coiled-coil domain containing 121
CD1E CD1e molecule
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CLCN4 chloride channel, voltage-sensitive 4
CNTN1 contactin 1
COL16A1 collagen, type XVI, alpha 1
CT62 cancer/testis antigen 62
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
CYTH3 cytohesin 3
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DCAF11 DDB1 and CUL4 associated factor 11
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DGCR8 DGCR8 microprocessor complex subunit
DMPK dystrophia myotonica-protein kinase
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DTNA dystrobrevin, alpha
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EDIL3 EGF-like repeats and discoidin I-like domains 3
EPHB3 EPH receptor B3
EPS8L1 EPS8-like 1
ESRRG estrogen-related receptor gamma
F13A1 coagulation factor XIII, A1 polypeptide
F13B coagulation factor XIII, B polypeptide
FANCC Fanconi anemia, complementation group C
FUBP1 far upstream element (FUSE) binding protein 1
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GIMAP5 GTPase, IMAP family member 5
GLB1L galactosidase, beta 1-like
GPR182 G protein-coupled receptor 182
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HOXC11 homeobox C11
IDI2-AS1 IDI2 antisense RNA 1
IL1RN interleukin 1 receptor antagonist
IL32 interleukin 32
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIR3DX1 killer cell immunoglobulin-like receptor, three domains, X1
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LIG3 ligase III, DNA, ATP-dependent
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAN1A2 mannosidase, alpha, class 1A, member 2
MAPK11 mitogen-activated protein kinase 11
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
NF1 neurofibromin 1
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
PAQR5 progestin and adipoQ receptor family member V
PBX2 pre-B-cell leukemia homeobox 2
PCDHGA1 protocadherin gamma subfamily A, 1
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDLIM5 PDZ and LIM domain 5
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PRDM1 PR domain containing 1, with ZNF domain
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB6B RAB6B, member RAS oncogene family
RGS4 regulator of G-protein signaling 4
RHEB Ras homolog enriched in brain
RIF1 replication timing regulatory factor 1
RIMS3 regulating synaptic membrane exocytosis 3
RNF32 ring finger protein 32
RNGTT RNA guanylyltransferase and 5'-phosphatase
S100A12 S100 calcium binding protein A12
SARM1 sterile alpha and TIR motif containing 1
SCAPER S-phase cyclin A-associated protein in the ER
SCARB1 scavenger receptor class B, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPPL2B signal peptide peptidase like 2B
SUGP1 SURP and G patch domain containing 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBX1 T-box 1
TBX2 T-box 2
TBXA2R thromboxane A2 receptor
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNIK TRAF2 and NCK interacting kinase
TNS1 tensin 1
TSPAN8 tetraspanin 8
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
UST uronyl-2-sulfotransferase
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF287 zinc finger protein 287
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ADAM2 ADAM metallopeptidase domain 2
ALB albumin
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANP32A-IT1 ANP32A intronic transcript 1
ANXA10 annexin A10
ARR3 arrestin 3, retinal (X-arrestin)
BDKRB1 bradykinin receptor B1
BMP10 bone morphogenetic protein 10
BTF3P11 basic transcription factor 3 pseudogene 11
C14ORF105 chromosome 14 open reading frame 105
C1ORF21 chromosome 1 open reading frame 21
C7ORF69 chromosome 7 open reading frame 69
CARD8 caspase recruitment domain family, member 8
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCDC85C coiled-coil domain containing 85C
CD68 CD68 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CDON cell adhesion associated, oncogene regulated
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNGB3 cyclic nucleotide gated channel beta 3
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPNE7 copine VII
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRMP1 collapsin response mediator protein 1
CYBRD1 cytochrome b reductase 1
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DPYS dihydropyrimidinase
DSPP dentin sialophosphoprotein
FKBP5 FK506 binding protein 5
FLJ21369 uncharacterized protein FLJ21369
GPRIN2 G protein regulated inducer of neurite outgrowth 2
H2AFJ H2A histone family, member J
HIST1H3A histone cluster 1, H3a
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXB9 homeobox B9
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IFT140 intraflagellar transport 140
INO80D INO80 complex subunit D
IQSEC2 IQ motif and Sec7 domain 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
KDM8 lysine (K)-specific demethylase 8
KIF13B kinesin family member 13B
KLHL28 kelch-like family member 28
KLHL36 kelch-like family member 36
KRT31 keratin 31, type I
KRT86 keratin 86, type II
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LPAR4 lysophosphatidic acid receptor 4
LY6D lymphocyte antigen 6 complex, locus D
MAGEF1 melanoma antigen family F1
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MGP matrix Gla protein
MTSS1L metastasis suppressor 1-like
MYO1D myosin ID
NLGN1 neuroligin 1
NPVF neuropeptide VF precursor
NTSR1 neurotensin receptor 1 (high affinity)
NXPH4 neurexophilin 4
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSBP2 oxysterol binding protein 2
PACS1 phosphofurin acidic cluster sorting protein 1
PCDH12 protocadherin 12
PCDHA5 protocadherin alpha 5
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PRR4 proline rich 4 (lacrimal)
RAPSN receptor-associated protein of the synapse
REM1 RAS (RAD and GEM)-like GTP-binding 1
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RUSC2 RUN and SH3 domain containing 2
SAMD9 sterile alpha motif domain containing 9
SCARA3 scavenger receptor class A, member 3
SCG2 secretogranin II
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC16A6 solute carrier family 16, member 6
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMR3A submaxillary gland androgen regulated protein 3A
STEAP4 STEAP family member 4
TCEAL2 transcription elongation factor A (SII)-like 2
THSD4 thrombospondin, type I, domain containing 4
TIGD6 tigger transposable element derived 6
TMEM212 transmembrane protein 212
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TUBA3C tubulin, alpha 3c
ZNF140 zinc finger protein 140
ZNF415 zinc finger protein 415
ZNF528 zinc finger protein 528
ZNF549 zinc finger protein 549
ZSCAN2 zinc finger and SCAN domain containing 2