tic disorder Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity. (Human Disease Ontology, DOID_2769)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:2769
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Genes

283 genes associated with the disease tic disorder in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
COL27A1 collagen, type XXVII, alpha 1 1.37327
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 1.02476
PHEX phosphate regulating endopeptidase homolog, X-linked 1.02476
ELMO1 engulfment and cell motility 1 0.885252
RGS6 regulator of G-protein signaling 6 0.87015
JADE2 jade family PHD finger 2 0.809818
SENP7 SUMO1/sentrin specific peptidase 7 0.800256
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial 0.786312
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 0.754216
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.749355
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 0.747128
MBP myelin basic protein 0.741181
STYX serine/threonine/tyrosine interacting protein 0.738895
CCDC40 coiled-coil domain containing 40 0.733103
TANK TRAF family member-associated NFKB activator 0.732392
MTUS1 microtubule associated tumor suppressor 1 0.7253
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.705334
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.696042
SYNPR synaptoporin 0.688771
MUC16 mucin 16, cell surface associated 0.686153
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 0.683601
EPHX2 epoxide hydrolase 2, cytoplasmic 0.678823
PTK2B protein tyrosine kinase 2 beta 0.677141
PICALM phosphatidylinositol binding clathrin assembly protein 0.663947
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.66115
HDLBP high density lipoprotein binding protein 0.654978
UNC13C unc-13 homolog C (C. elegans) 0.654134
COG6 component of oligomeric golgi complex 6 0.653298
KIAA1217 KIAA1217 0.651654
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.64532
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.644215
ATP9A ATPase, class II, type 9A 0.64367
FOXK2 forkhead box K2 0.639985
ERLEC1 endoplasmic reticulum lectin 1 0.637975
DLC1 DLC1 Rho GTPase activating protein 0.637483
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.636031
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.634612
LOC100507377 uncharacterized LOC100507377 0.633226
AKAP2 A kinase (PRKA) anchor protein 2 0.632771
SEZ6L seizure related 6 homolog (mouse)-like 0.631427
ADCY2 adenylate cyclase 2 (brain) 0.628075
ESRRG estrogen-related receptor gamma 0.626482
LRRK2 leucine-rich repeat kinase 2 0.625701
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.624172
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.623796
EGFL6 EGF-like-domain, multiple 6 0.620873
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.620873
LEKR1 leucine, glutamate and lysine rich 1 0.620165
TLK1 tousled-like kinase 1 0.61912
BTG4 B-cell translocation gene 4 0.618434
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 0.618094
NIPAL1 NIPA-like domain containing 1 0.61742
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.614416
KDM5A lysine (K)-specific demethylase 5A 0.614416
PSD3 pleckstrin and Sec7 domain containing 3 0.614068
CNTN4 contactin 4 0.613722
LOC100134391 uncharacterized LOC100134391 0.612021
DSCC1 DNA replication and sister chromatid cohesion 1 0.611686
GLIS3 GLIS family zinc finger 3 0.610366
SNX24 sorting nexin 24 0.610041
FAM155A family with sequence similarity 155, member A 0.605359
CERS2 ceramide synthase 2 0.603584
PAIP2B poly(A) binding protein interacting protein 2B 0.601018
LINC00316 long intergenic non-protein coding RNA 316 0.59854
CDH13 cadherin 13 0.596242
RASGEF1A RasGEF domain family, member 1A 0.595401
FREM1 FRAS1 related extracellular matrix 1 0.594847
GALK2 galactokinase 2 0.593752
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.590323
BCAS4 breast carcinoma amplified sequence 4 0.589304
CSMD1 CUB and Sushi multiple domains 1 0.588551
MLIP muscular LMNA-interacting protein 0.588302
CTPS2 CTP synthase 2 0.588054
LDB3 LIM domain binding 3 0.587807
SIRPA signal-regulatory protein alpha 0.587561
CNTN1 contactin 1 0.585865
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 0.585152
ZBTB16 zinc finger and BTB domain containing 16 0.584448
ANXA10 annexin A10 0.583982
SMAD7 SMAD family member 7 0.581481
BPIFC BPI fold containing family C 0.58124
PAX3 paired box 3 0.580046
CAMKMT calmodulin-lysine N-methyltransferase 0.580046
MED12L mediator complex subunit 12-like 0.578874
ARID1B AT rich interactive domain 1B (SWI1-like) 0.578181
BSN bassoon presynaptic cytomatrix protein 0.578181
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.577723
EDA ectodysplasin A 0.577495
LOC145845 uncharacterized LOC145845 0.577268
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.577041
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.575039
LINGO2 leucine rich repeat and Ig domain containing 2 0.574169
NTN1 netrin 1 0.574169
OSMR oncostatin M receptor 0.573738
FAM19A1 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 0.572885
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.570595
TBC1D7 TBC1 domain family, member 7 0.569782
LAYN layilin 0.569379
ASB1 ankyrin repeat and SOCS box containing 1 0.569379
LPO lactoperoxidase 0.568979
LONRF3 LON peptidase N-terminal domain and ring finger 3 0.568979
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 0.568581
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 0.567989
CLEC7A C-type lectin domain family 7, member A 0.567989
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.567598
AFAP1L1 actin filament associated protein 1-like 1 0.566629
LOC349160 uncharacterized LOC349160 0.565675
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.564921
LOC284788 uncharacterized LOC284788 0.564734
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.564548
ZNF423 zinc finger protein 423 0.564177
MPO myeloperoxidase 0.562261
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.562068
RBMS1 RNA binding motif, single stranded interacting protein 1 0.560539
LHFPL3 lipoma HMGIC fusion partner-like 3 0.560163
LRP1B low density lipoprotein receptor-related protein 1B 0.558127
GLP2R glucagon-like peptide 2 receptor 0.557222
SNTG2 syntrophin, gamma 2 0.555099
CNTN5 contactin 5 0.555099
CMIP c-Maf inducing protein 0.554751
THSD4 thrombospondin, type I, domain containing 4 0.554751
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.554234
CA10 carbonic anhydrase X 0.552202
TRAK1 trafficking protein, kinesin binding 1 0.552035
SNTG1 syntrophin, gamma 1 0.551704
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.551209
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.549747
KCNIP4 Kv channel interacting protein 4 0.548949
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 0.54879
RPS15A ribosomal protein S15a 0.54816
FAM179B family with sequence similarity 179, member B 0.54816
NAV2 neuron navigator 2 0.548003
TRAM2 translocation associated membrane protein 2 0.547535
BCAS1 breast carcinoma amplified sequence 1 0.547225
FAM124B family with sequence similarity 124B 0.545848
SPAG16 sperm associated antigen 16 0.545546
C12ORF42 chromosome 12 open reading frame 42 0.544469
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.544152
OSBPL10 oxysterol binding protein-like 10 0.54368
PDGFRL platelet-derived growth factor receptor-like 0.543055
TENM2 teneurin transmembrane protein 2 0.542744
MEF2C myocyte enhancer factor 2C 0.542281
DGKB diacylglycerol kinase, beta 90kDa 0.542281
CAPS2 calcyphosine 2 0.540609
CLEC4A C-type lectin domain family 4, member A 0.54016
VILL villin-like 0.539124
MAST4 microtubule associated serine/threonine kinase family member 4 0.538978
AGR3 anterior gradient 3 0.538539
ANO7 anoctamin 7 0.536955
SEPT2 septin 2 0.536388
VWA8 von Willebrand factor A domain containing 8 0.536107
PCLO piccolo presynaptic cytomatrix protein 0.534578
ADGRF3 adhesion G protein-coupled receptor F3 0.534304
ARHGAP15 Rho GTPase activating protein 15 0.53403
COL23A1 collagen, type XXIII, alpha 1 0.533352
FHOD3 formin homology 2 domain containing 3 0.533217
LINC01588 long intergenic non-protein coding RNA 1588 0.531357
DNAI2 dynein, axonemal, intermediate chain 2 0.530965
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.530835
MDN1 MDN1, midasin homolog (yeast) 0.530446
GALM galactose mutarotase (aldose 1-epimerase) 0.530317
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 0.529803
ZDHHC14 zinc finger, DHHC-type containing 14 0.527785
DLG2 discs, large homolog 2 (Drosophila) 0.527537
CLECL1 C-type lectin-like 1 0.52729
LOC100288181 uncharacterized LOC100288181 0.527043
PRICKLE2 prickle homolog 2 (Drosophila) 0.527043
RELN reelin 0.52631
SH3GL2 SH3-domain GRB2-like 2 0.526067
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 0.525705
GAS6 growth arrest-specific 6 0.525103
SGMS1 sphingomyelin synthase 1 0.524151
ANO4 anoctamin 4 0.524151
ANXA9 annexin A9 0.523681
CCDC12 coiled-coil domain containing 12 0.523681
HDAC9 histone deacetylase 9 0.523681
AKAP6 A kinase (PRKA) anchor protein 6 0.523681
ESRRB estrogen-related receptor beta 0.522403
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 0.521263
KLHL3 kelch-like family member 3 0.521037
MACROD2 MACRO domain containing 2 0.520812
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.519809
LOC100506446 uncharacterized LOC100506446 0.519809
FGF14 fibroblast growth factor 14 0.519698
ZNF816 zinc finger protein 816 0.519478
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.519368
SLC35F1 solute carrier family 35, member F1 0.519258
CFAP58 cilia and flagella associated protein 58 0.51893
STK31 serine/threonine kinase 31 0.518603
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.518063
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.517847
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 0.517633
GORASP2 golgi reassembly stacking protein 2, 55kDa 0.517633
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 0.517313
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.516677
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.516571
COL6A2 collagen, type VI, alpha 2 0.516361
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.516047
NTM neurotrimin 0.51563
MTUS2 microtubule associated tumor suppressor candidate 2 0.515423
TSHZ2 teashirt zinc finger homeobox 2 0.514295
MORN5 MORN repeat containing 5 0.51399
CLSTN2 calsyntenin 2 0.513788
VWC2L von Willebrand factor C domain containing protein 2-like 0.513385
SH3TC2 SH3 domain and tetratricopeptide repeats 2 0.513385
ZNF681 zinc finger protein 681 0.512886
GLG1 golgi glycoprotein 1 0.512588
PUM1 pumilio RNA-binding family member 1 0.512489
CNTNAP2 contactin associated protein-like 2 0.5118
LINC00583 long intergenic non-protein coding RNA 583 0.511507
AMPD3 adenosine monophosphate deaminase 3 0.510828
RHOA ras homolog family member A 0.51054
EXOC4 exocyst complex component 4 0.510444
AKAP13 A kinase (PRKA) anchor protein 13 0.510444
FHIT fragile histidine triad 0.510348
FAM19A4 family with sequence similarity 19 (chemokine (C-C motif)-like), member A4 0.510348
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.510348
GRM7 glutamate receptor, metabotropic 7 0.510061
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.509681
ADD1 adducin 1 (alpha) 0.509397
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.509115
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.509115
AFF3 AF4/FMR2 family, member 3 0.507905
LPP LIM domain containing preferred translocation partner in lipoma 0.507905
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.507721
RAB3C RAB3C, member RAS oncogene family 0.507539
LINC01550 long intergenic non-protein coding RNA 1550 0.507466
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.507394
ATRNL1 attractin-like 1 0.507322
CCDC146 coiled-coil domain containing 146 0.507322
SECISBP2L SECIS binding protein 2-like 0.507249
ZNF365 zinc finger protein 365 0.506531
ACVR1 activin A receptor, type I 0.505964
KDM4D lysine (K)-specific demethylase 4D 0.505964
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.505964
RBM45 RNA binding motif protein 45 0.505823
PRKCH protein kinase C, eta 0.505543
SPPL3 signal peptide peptidase like 3 0.505264
ROR2 receptor tyrosine kinase-like orphan receptor 2 0.505055
EPB41 erythrocyte membrane protein band 4.1 0.504986
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 0.504848
ADGRG1 adhesion G protein-coupled receptor G1 0.504572
TSPAN9 tetraspanin 9 0.504572
SYK spleen tyrosine kinase 0.504504
SLC38A1 solute carrier family 38, member 1 0.504435
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2 0.50423
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 0.504094
SP100 SP100 nuclear antigen 0.503958
ZNF638 zinc finger protein 638 0.503822
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 0.503754
ACYP2 acylphosphatase 2, muscle type 0.503485
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.50275
TRDN triadin 0.501504
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.501375
CELF2 CUGBP, Elav-like family member 2 0.501181
PRDM16 PR domain containing 16 0.501117
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.500989
DOCK2 dedicator of cytokinesis 2 0.500797
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.500797
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 0.500478
TTC39C tetratricopeptide repeat domain 39C 0.500098
DOK6 docking protein 6 0.500098
CRTC3 CREB regulated transcription coactivator 3 0.499973
PCDH9 protocadherin 9 0.499784
KRT4 keratin 4, type II 0.499659
AGBL1 ATP/GTP binding protein-like 1 0.499597
DMD dystrophin 0.499534
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.499472
TEX14 testis expressed 14 0.499223
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 0.499161
FBN2 fibrillin 2 0.49873
SLC12A8 solute carrier family 12, member 8 0.498119
PRKCE protein kinase C, epsilon 0.497696
RCSD1 RCSD domain containing 1 0.497516
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 0.497336
GPC4 glypican 4 0.497276
PDE4D phosphodiesterase 4D, cAMP-specific 0.497157
MATN2 matrilin 2 0.497098
NRG1 neuregulin 1 0.497038
ANXA6 annexin A6 0.496801
DIO3 deiodinase, iodothyronine, type III 0.496447
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.496389
MRPL19 mitochondrial ribosomal protein L19 0.49633