tic disorder Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity. (Human Disease Ontology, DOID_2769)
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Genes

175 genes co-occuring with the disease tic disorder in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SLITRK1 SLIT and NTRK-like family, member 1 2.03426
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 1.85592
OFCC1 orofacial cleft 1 candidate 1 1.67457
DRD2 dopamine receptor D2 1.56089
DRD4 dopamine receptor D4 1.52424
BTBD9 BTB (POZ) domain containing 9 1.52116
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 1.45748
TDO2 tryptophan 2,3-dioxygenase 1.45572
ADD2 adducin 2 (beta) 1.37599
KLHL32 kelch-like family member 32 1.35028
C11ORF45 chromosome 11 open reading frame 45 1.35028
GPR63 G protein-coupled receptor 63 1.35028
SGCE sarcoglycan, epsilon 1.3241
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.31624
KCTD3 potassium channel tetramerization domain containing 3 1.31013
ADRA2A adrenoceptor alpha 2A 1.2508
AKAP17A A kinase (PRKA) anchor protein 17A 1.24558
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.19834
DRD5 dopamine receptor D5 1.19057
MRPL3 mitochondrial ribosomal protein L3 1.18798
PABPC5 poly(A) binding protein, cytoplasmic 5 1.16307
USP3 ubiquitin specific peptidase 3 1.15368
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 1.12151
CNTNAP2 contactin associated protein-like 2 1.11267
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.1051
WDR60 WD repeat domain 60 1.0669
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.04588
CSNK1G2 casein kinase 1, gamma 2 1.03367
CBLN2 cerebellin 2 precursor 1.01427
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 1.00879
ACP1 acid phosphatase 1, soluble 1.00077
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.988957
NKG7 natural killer cell granule protein 7 0.983479
ALG9 ALG9, alpha-1,2-mannosyltransferase 0.976323
SKOR1 SKI family transcriptional corepressor 1 0.967502
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.958287
ADRA2C adrenoceptor alpha 2C 0.942443
GNG7 guanine nucleotide binding protein (G protein), gamma 7 0.939534
TPH2 tryptophan hydroxylase 2 0.902389
AP4M1 adaptor-related protein complex 4, mu 1 subunit 0.893769
DRD3 dopamine receptor D3 0.880653
NDUFA4 NDUFA4, mitochondrial complex associated 0.872872
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.856087
TBCD tubulin folding cofactor D 0.848716
GINS2 GINS complex subunit 2 (Psf2 homolog) 0.835607
MAOA monoamine oxidase A 0.822488
COMT catechol-O-methyltransferase 0.821667
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.820847
EFS embryonal Fyn-associated substrate 0.806077
LHX8 LIM homeobox 8 0.800744
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 0.800333
STXBP5 syntaxin binding protein 5 (tomosyn) 0.800333
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 0.787213
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 0.761454
LHX6 LIM homeobox 6 0.760231
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.755749
PEX16 peroxisomal biogenesis factor 16 0.74761
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.745985
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.745578
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 0.739894
DRD1 dopamine receptor D1 0.73746
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 0.732596
MAP2K5 mitogen-activated protein kinase kinase 5 0.724502
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 0.722077
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.712392
OAZ3 ornithine decarboxylase antizyme 3 0.705547
PVALB parvalbumin 0.703938
GCH1 GTP cyclohydrolase 1 0.701928
CAMKV CaM kinase-like vesicle-associated 0.701124
PRICKLE1 prickle homolog 1 (Drosophila) 0.701124
PURA purine-rich element binding protein A 0.67312
COL8A1 collagen, type VIII, alpha 1 0.668345
MAPRE2 microtubule-associated protein, RP/EB family, member 2 0.648928
NLGN4X neuroligin 4, X-linked 0.638676
ARRB2 arrestin, beta 2 0.637495
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.635135
AUTS2 autism susceptibility candidate 2 0.625319
PKLR pyruvate kinase, liver and RBC 0.613183
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 0.612401
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.608885
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.608885
CNR1 cannabinoid receptor 1 (brain) 0.604201
HCRTR1 hypocretin (orexin) receptor 1 0.60225
FAM195A family with sequence similarity 195, member A 0.596402
DPP6 dipeptidyl-peptidase 6 0.581217
TRAPPC9 trafficking protein particle complex 9 0.581217
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 0.577327
HDC histidine decarboxylase 0.560227
OLIG1 oligodendrocyte transcription factor 1 0.552851
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 0.549747
PKM pyruvate kinase, muscle 0.545481
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.529608
KCNK9 potassium channel, two pore domain subfamily K, member 9 0.528063
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.527676
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 0.525746
CSMD1 CUB and Sushi multiple domains 1 0.506123
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 0.505356
DAOA D-amino acid oxidase activator 0.499997
CLCN2 chloride channel, voltage-sensitive 2 0.493885
TDP1 tyrosyl-DNA phosphodiesterase 1 0.487027
ITGA1 integrin, alpha 1 0.486266
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.481705
FGF19 fibroblast growth factor 19 0.481325
A4GALT alpha 1,4-galactosyltransferase 0.480566
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 0.462394
PCDH11X protocadherin 11 X-linked 0.452962
PANK1 pantothenate kinase 1 0.452208
MANBA mannosidase, beta A, lysosomal 0.452208
HMBS hydroxymethylbilane synthase 0.443171
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.442418
CRY2 cryptochrome circadian clock 2 0.433397
CLIP1 CAP-GLY domain containing linker protein 1 0.430768
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.420266
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.419142
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.410161
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.409414
NADK NAD kinase 0.401945
HCRT hypocretin (orexin) neuropeptide precursor 0.39598
CD69 CD69 molecule 0.392629
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.389653
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.388909
HRH3 histamine receptor H3 0.381481
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.373328
DLG4 discs, large homolog 4 (Drosophila) 0.372958
FOXP2 forkhead box P2 0.371107
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 0.366301
NRXN1 neurexin 1 0.359657
FAT1 FAT atypical cadherin 1 0.355235
NRCAM neuronal cell adhesion molecule 0.350452
HPRT1 hypoxanthine phosphoribosyltransferase 1 0.345308
VIM vimentin 0.344574
BDNF brain-derived neurotrophic factor 0.34384
NPEPPS aminopeptidase puromycin sensitive 0.34384
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.328834
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 0.324458
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.321181
PTPRN protein tyrosine phosphatase, receptor type, N 0.319363
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.311014
FPGS folylpolyglutamate synthase 0.304864
PTPRD protein tyrosine phosphatase, receptor type, D 0.304503
WDR20 WD repeat domain 20 0.298371
CAMP cathelicidin antimicrobial peptide 0.295851
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.294772
FGA fibrinogen alpha chain 0.293694
PANK2 pantothenate kinase 2 0.292257
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.280796
CEP290 centrosomal protein 290kDa 0.280796
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.276158
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.275801
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.274021
LARGE like-glycosyltransferase 0.271174
MEIS1 Meis homeobox 1 0.259477
FGF10 fibroblast growth factor 10 0.258417
KLRC1 killer cell lectin-like receptor subfamily C, member 1 0.245046
NCR1 natural cytotoxicity triggering receptor 1 0.245046
SOD1 superoxide dismutase 1, soluble 0.241546
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.240847
AMPH amphiphysin 0.238752
OLIG2 oligodendrocyte lineage transcription factor 2 0.233878
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.228333
APRT adenine phosphoribosyltransferase 0.222136
TH tyrosine hydroxylase 0.218034
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.212608
PNMT phenylethanolamine N-methyltransferase 0.201635
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.196139
ISL1 ISL LIM homeobox 1 0.190476
MOG myelin oligodendrocyte glycoprotein 0.190476
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.18591
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.185016
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.172544
PTS 6-pyruvoyltetrahydropterin synthase 0.164571
THRB thyroid hormone receptor, beta 0.159124
MC4R melanocortin 4 receptor 0.157765
F12 coagulation factor XII (Hageman factor) 0.15116
ENO2 enolase 2 (gamma, neuronal) 0.142506