tiabendazole-4402 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the tiabendazole-4402 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ADAM12 ADAM metallopeptidase domain 12
ADAM28 ADAM metallopeptidase domain 28
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ADAM8 ADAM metallopeptidase domain 8
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ALOX12 arachidonate 12-lipoxygenase
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BMP6 bone morphogenetic protein 6
C10ORF10 chromosome 10 open reading frame 10
CCDC81 coiled-coil domain containing 81
CCIN calicin
CD8A CD8a molecule
CELA2A chymotrypsin-like elastase family, member 2A
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC7A C-type lectin domain family 7, member A
CNTN5 contactin 5
CORO2B coronin, actin binding protein, 2B
CPA2 carboxypeptidase A2 (pancreatic)
CRISP2 cysteine-rich secretory protein 2
CTSZ cathepsin Z
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DIO2 deiodinase, iodothyronine, type II
DNAH17 dynein, axonemal, heavy chain 17
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DOK2 docking protein 2, 56kDa
EFS embryonal Fyn-associated substrate
EPN1 epsin 1
ERC2-IT1 ERC2 intronic transcript 1
FAM13C family with sequence similarity 13, member C
FAM189A1 family with sequence similarity 189, member A1
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GAB1 GRB2-associated binding protein 1
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GOLGA6A golgin A6 family, member A
GP1BB glycoprotein Ib (platelet), beta polypeptide
GPR162 G protein-coupled receptor 162
GRIP2 glutamate receptor interacting protein 2
GRK4 G protein-coupled receptor kinase 4
GRM7 glutamate receptor, metabotropic 7
HFE hemochromatosis
HLA-DOA major histocompatibility complex, class II, DO alpha
HOXA7 homeobox A7
HPCAL4 hippocalcin like 4
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HRH1 histamine receptor H1
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
IBSP integrin-binding sialoprotein
IFNA14 interferon, alpha 14
IGKV3-20 immunoglobulin kappa variable 3-20
IGLJ3 immunoglobulin lambda joining 3
IHH indian hedgehog
IL23A interleukin 23, alpha subunit p19
INA internexin neuronal intermediate filament protein, alpha
KALRN kalirin, RhoGEF kinase
KIF21B kinesin family member 21B
KLF9 Kruppel-like factor 9
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LTBP4 latent transforming growth factor beta binding protein 4
MED25 mediator complex subunit 25
MUC8 mucin 8
MYO15A myosin XVA
MYOZ1 myozenin 1
NOVA1 neuro-oncological ventral antigen 1
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NUDC nudC nuclear distribution protein
PLD1 phospholipase D1, phosphatidylcholine-specific
PLVAP plasmalemma vesicle associated protein
POU3F2 POU class 3 homeobox 2
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PTAFR platelet-activating factor receptor
RASAL2 RAS protein activator like 2
RHBDL1 rhomboid, veinlet-like 1 (Drosophila)
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RUNX1 runt-related transcription factor 1
S100A1 S100 calcium binding protein A1
S100A7 S100 calcium binding protein A7
SAG S-antigen; retina and pineal gland (arrestin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE3 signal peptide, CUB domain, EGF-like 3
SFTPD surfactant protein D
SMAD5-AS1 SMAD5 antisense RNA 1
SNAP25 synaptosomal-associated protein, 25kDa
TCF12 transcription factor 12
TECPR2 tectonin beta-propeller repeat containing 2
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNK2 tyrosine kinase, non-receptor, 2
TPP1 tripeptidyl peptidase I
TRD T cell receptor delta locus
TTC38 tetratricopeptide repeat domain 38
UBR4 ubiquitin protein ligase E3 component n-recognin 4
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
WDR78 WD repeat domain 78
WTAP Wilms tumor 1 associated protein
ZBED4 zinc finger, BED-type containing 4
ZBTB33 zinc finger and BTB domain containing 33

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACADSB acyl-CoA dehydrogenase, short/branched chain
ALOX15 arachidonate 15-lipoxygenase
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOM apolipoprotein M
ARC activity-regulated cytoskeleton-associated protein
BAX BCL2-associated X protein
C11ORF30 chromosome 11 open reading frame 30
CA5BP1 carbonic anhydrase VB pseudogene 1
CD3D CD3d molecule, delta (CD3-TCR complex)
CPNE7 copine VII
CTSF cathepsin F
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DEAF1 DEAF1 transcription factor
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DPY19L1P1 DPY19L1 pseudogene 1
DYSF dysferlin
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGF13 fibroblast growth factor 13
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAS2 growth arrest-specific 2
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HDAC5 histone deacetylase 5
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HHAT hedgehog acyltransferase
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HOXC5 homeobox C5
HYI hydroxypyruvate isomerase (putative)
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL12RB1 interleukin 12 receptor, beta 1
IL22 interleukin 22
IL4R interleukin 4 receptor
IRF9 interferon regulatory factor 9
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCTD7 potassium channel tetramerization domain containing 7
KLHL25 kelch-like family member 25
KPNA5 karyopherin alpha 5 (importin alpha 6)
KREMEN2 kringle containing transmembrane protein 2
LMNB1 lamin B1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MEFV Mediterranean fever
MFAP2 microfibrillar-associated protein 2
MRPL41 mitochondrial ribosomal protein L41
MX2 MX dynamin-like GTPase 2
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NDRG1 N-myc downstream regulated 1
NME5 NME/NM23 family member 5
NXPE3 neurexophilin and PC-esterase domain family, member 3
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PARP12 poly (ADP-ribose) polymerase family, member 12
PCDHA6 protocadherin alpha 6
PCDHB13 protocadherin beta 13
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PRICKLE3 prickle homolog 3 (Drosophila)
PRKCE protein kinase C, epsilon
RAB3D RAB3D, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RCAN3 RCAN family member 3
RNF126P1 ring finger protein 126 pseudogene 1
RNF170 ring finger protein 170
RNF2 ring finger protein 2
SCD5 stearoyl-CoA desaturase 5
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SP1 Sp1 transcription factor
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TARP TCR gamma alternate reading frame protein
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TMEM120B transmembrane protein 120B
TMEM209 transmembrane protein 209
TMEM254 transmembrane protein 254
TMEM62 transmembrane protein 62
TPSG1 tryptase gamma 1
TRIM21 tripartite motif containing 21
TRIM5 tripartite motif containing 5
UBQLN4 ubiquilin 4
VASH2 vasohibin 2
VEGFB vascular endothelial growth factor B
VEZT vezatin, adherens junctions transmembrane protein
WDR33 WD repeat domain 33
WDR47 WD repeat domain 47
WDR91 WD repeat domain 91
YY2 YY2 transcription factor
ZDHHC14 zinc finger, DHHC-type containing 14
ZFHX2 zinc finger homeobox 2
ZNF16 zinc finger protein 16
ZNF253 zinc finger protein 253
ZNF34 zinc finger protein 34
ZNF747 zinc finger protein 747
ZNF76 zinc finger protein 76