thrombotic thrombocytopenic purpura Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

115 genes co-occuring with the disease thrombotic thrombocytopenic purpura in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 4.02482
VWF von Willebrand factor 2.83664
CD46 CD46 molecule, complement regulatory protein 1.56222
THBD thrombomodulin 1.55823
CABIN1 calcineurin binding protein 1 1.53745
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 1.50711
CFH complement factor H 1.45353
HP haptoglobin 1.32847
HPR haptoglobin-related protein 1.32148
F3 coagulation factor III (thromboplastin, tissue factor) 1.28523
F8 coagulation factor VIII, procoagulant component 1.24819
THBS1 thrombospondin 1 1.22909
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 1.12151
STX2 syntaxin 2 1.11015
STX1A syntaxin 1A (brain) 1.09167
F2 coagulation factor II (thrombin) 0.985585
MMP25 matrix metallopeptidase 25 0.933313
C5 complement component 5 0.927932
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.921323
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.892129
PLG plasminogen 0.872872
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 0.865502
APOH apolipoprotein H (beta-2-glycoprotein I) 0.788442
DGKE diacylglycerol kinase, epsilon 64kDa 0.785165
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 0.730976
EHD4 EH-domain containing 4 0.71078
VEGFA vascular endothelial growth factor A 0.703536
POFUT2 protein O-fucosyltransferase 2 0.695905
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.686691
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.684292
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.681096
CFHR1 complement factor H-related 1 0.669538
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.663975
PF4 platelet factor 4 0.661197
F5 coagulation factor V (proaccelerin, labile factor) 0.650903
NCK1 NCK adaptor protein 1 0.649323
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 0.644981
ACE angiotensin I converting enzyme 0.625319
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 0.61866
HUNK hormonally up-regulated Neu-associated kinase 0.610448
PLAT plasminogen activator, tissue 0.6003
C5AR1 complement component 5a receptor 1 0.6003
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.592506
MAEA macrophage erythroblast attacher 0.586276
EHD3 EH-domain containing 3 0.575383
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.569163
SELE selectin E 0.565666
ALB albumin 0.543542
GP1BA glycoprotein Ib (platelet), alpha polypeptide 0.52536
HLA-C major histocompatibility complex, class I, C 0.516494
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.509959
VCAM1 vascular cell adhesion molecule 1 0.480945
HIST1H2BG histone cluster 1, H2bg 0.480566
HIST1H2BE histone cluster 1, H2be 0.480566
HIST1H2BI histone cluster 1, H2bi 0.480566
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 0.469576
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 0.468819
PROS1 protein S (alpha) 0.462772
ADAMTSL4 ADAMTS-like 4 0.460883
ADAMTSL2 ADAMTS-like 2 0.448064
FGL2 fibrinogen-like 2 0.446935
GPR182 G protein-coupled receptor 182 0.427015
HSH2D hematopoietic SH2 domain containing 0.426265
CFHR3 complement factor H-related 3 0.420641
C3 complement component 3 0.420266
SCARB2 scavenger receptor class B, member 2 0.416896
PPIC peptidylprolyl isomerase C (cyclophilin C) 0.415024
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 0.413901
CD36 CD36 molecule (thrombospondin receptor) 0.401572
IFNB1 interferon, beta 1, fibroblast 0.401199
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.400826
TNF tumor necrosis factor 0.400826
NONO non-POU domain containing, octamer-binding 0.388538
CD79A CD79a molecule, immunoglobulin-associated alpha 0.387794
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.386308
RBMS2 RNA binding motif, single stranded interacting protein 2 0.377402
CD4 CD4 molecule 0.377402
NOS3 nitric oxide synthase 3 (endothelial cell) 0.365932
TNNT2 troponin T type 2 (cardiac) 0.364824
SCARB1 scavenger receptor class B, member 1 0.361133
APLN apelin 0.350084
CMIP c-Maf inducing protein 0.340173
FKBP9 FK506 binding protein 9, 63 kDa 0.320817
FKBP7 FK506 binding protein 7 0.318635
FKBP3 FK506 binding protein 3, 25kDa 0.307757
CFI complement factor I 0.307757
CFB complement factor B 0.296931
GLRA2 glycine receptor, alpha 2 0.296571
FKBP6 FK506 binding protein 6, 36kDa 0.293694
CD40LG CD40 ligand 0.287593
CD34 CD34 molecule 0.272241
STAC SH3 and cysteine rich domain 0.263368
MPO myeloperoxidase 0.263014
DSG4 desmoglein 4 0.253127
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.246448
STX1B syntaxin 1B 0.243645
RARA retinoic acid receptor, alpha 0.242595
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.23666
REN renin 0.225229
LDHC lactate dehydrogenase C 0.219057
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.218034
SRRM2 serine/arginine repetitive matrix 2 0.213283
FKBP2 FK506 binding protein 2, 13kDa 0.20658
IGHV3-9 immunoglobulin heavy variable 3-9 0.205916
TMPRSS13 transmembrane protease, serine 13 0.199356
TBXAS1 thromboxane A synthase 1 (platelet) 0.199033
IGLV9-49 immunoglobulin lambda variable 9-49 0.194865
CDC27 cell division cycle 27 0.189551
CFHR5 complement factor H-related 5 0.182957
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 0.180937
PLAU plasminogen activator, urokinase 0.180367
FN1 fibronectin 1 0.164786
PRTN3 proteinase 3 0.160574
FKBP10 FK506 binding protein 10, 65 kDa 0.159124
DSG1 desmoglein 1 0.158951