thioridazine-4454 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the thioridazine-4454 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AMIGO2 adhesion molecule with Ig-like domain 2
ARC activity-regulated cytoskeleton-associated protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP10B ATPase, class V, type 10B
BIK BCL2-interacting killer (apoptosis-inducing)
BMP2 bone morphogenetic protein 2
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C10ORF10 chromosome 10 open reading frame 10
C1ORF116 chromosome 1 open reading frame 116
C1ORF54 chromosome 1 open reading frame 54
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN1 claudin 1
CPEB3 cytoplasmic polyadenylation element binding protein 3
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FERMT2 fermitin family member 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GK glycerol kinase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HDAC9 histone deacetylase 9
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL11 interleukin 11
IL1RL1 interleukin 1 receptor-like 1
IL24 interleukin 24
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUND jun D proto-oncogene
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM7A lysine (K)-specific demethylase 7A
KLHL24 kelch-like family member 24
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT34 keratin 34, type I
LARP6 La ribonucleoprotein domain family, member 6
LIPE lipase, hormone-sensitive
MAGEA5 melanoma antigen family A5
MEF2D myocyte enhancer factor 2D
MMP10 matrix metallopeptidase 10
MMP13 matrix metallopeptidase 13
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OASL 2'-5'-oligoadenylate synthetase-like
PALM paralemmin
PDE10A phosphodiesterase 10A
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRH protein tyrosine phosphatase, receptor type, H
PTPRR protein tyrosine phosphatase, receptor type, R
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS4 regulator of G-protein signaling 4
RND1 Rho family GTPase 1
RRAD Ras-related associated with diabetes
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STK17B serine/threonine kinase 17b
SYT1 synaptotagmin I
TGFB2 transforming growth factor, beta 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRIB3 tribbles pseudokinase 3
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
AAAS achalasia, adrenocortical insufficiency, alacrimia
ADGRB2 adhesion G protein-coupled receptor B2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARPIN actin-related protein 2/3 complex inhibitor
ATP10D ATPase, class V, type 10D
B3GNT1
BAHCC1 BAH domain and coiled-coil containing 1
BNC1 basonuclin 1
C14ORF93 chromosome 14 open reading frame 93
C1QTNF3 C1q and tumor necrosis factor related protein 3
C7ORF43 chromosome 7 open reading frame 43
CCNE2 cyclin E2
CCP110 centriolar coiled coil protein 110kDa
CDC7 cell division cycle 7
CHAF1B chromatin assembly factor 1, subunit B (p60)
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNIH3 cornichon family AMPA receptor auxiliary protein 3
COL9A3 collagen, type IX, alpha 3
CPEB1 cytoplasmic polyadenylation element binding protein 1
CSF1R colony stimulating factor 1 receptor
DDN dendrin
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EHD3 EH-domain containing 3
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EPN3 epsin 3
ETV4 ets variant 4
FKBP5 FK506 binding protein 5
GALK1 galactokinase 1
GAREM GRB2 associated, regulator of MAPK1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GRPR gastrin-releasing peptide receptor
GSTCD glutathione S-transferase, C-terminal domain containing
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXB13 homeobox B13
IDI2-AS1 IDI2 antisense RNA 1
IQCG IQ motif containing G
IRAK4 interleukin-1 receptor-associated kinase 4
IRF2BP1 interferon regulatory factor 2 binding protein 1
KIAA1107 KIAA1107
KIAA1549L KIAA1549-like
KLHL3 kelch-like family member 3
LMNB1 lamin B1
LOC730101 uncharacterized LOC730101
LONP2 lon peptidase 2, peroxisomal
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LRRC61 leucine rich repeat containing 61
LY6G5C lymphocyte antigen 6 complex, locus G5C
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LYPLA2P1 lysophospholipase II pseudogene 1
MANSC1 MANSC domain containing 1
MED24 mediator complex subunit 24
MXRA8 matrix-remodelling associated 8
NCALD neurocalcin delta
NDP Norrie disease (pseudoglioma)
NOL12 nucleolar protein 12
NPFFR1 neuropeptide FF receptor 1
NPY1R neuropeptide Y receptor Y1
ORC1 origin recognition complex, subunit 1
PALMD palmdelphin
PCOLCE procollagen C-endopeptidase enhancer
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PMCH pro-melanin-concentrating hormone
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLL polymerase (DNA directed), lambda
PRKG2 protein kinase, cGMP-dependent, type II
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RIBC2 RIB43A domain with coiled-coils 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC46A3 solute carrier family 46, member 3
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLITRK5 SLIT and NTRK-like family, member 5
SNHG20 small nucleolar RNA host gene 20
SNRPN small nuclear ribonucleoprotein polypeptide N
SP1 Sp1 transcription factor
SYK spleen tyrosine kinase
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THRAP3 thyroid hormone receptor associated protein 3
TMEM120B transmembrane protein 120B
TMEM121 transmembrane protein 121
TMEM206 transmembrane protein 206
TRIM9 tripartite motif containing 9
TUBA3C tubulin, alpha 3c
TUBA4B tubulin, alpha 4b
UGT8 UDP glycosyltransferase 8
UNG uracil-DNA glycosylase
VGLL3 vestigial-like family member 3
WNT16 wingless-type MMTV integration site family, member 16
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF180 zinc finger protein 180
ZNF215 zinc finger protein 215
ZNF273 zinc finger protein 273
ZNF528 zinc finger protein 528
ZNF668 zinc finger protein 668