thioridazine-422 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the thioridazine-422 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGBL5 ATP/GTP binding protein-like 5
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
APOC1 apolipoprotein C-I
AQP3 aquaporin 3 (Gill blood group)
ASXL1 additional sex combs like transcriptional regulator 1
C12ORF43 chromosome 12 open reading frame 43
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C22ORF29 chromosome 22 open reading frame 29
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CD164 CD164 molecule, sialomucin
CD82 CD82 molecule
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CHD3 chromodomain helicase DNA binding protein 3
CHKB choline kinase beta
CHRM4 cholinergic receptor, muscarinic 4
CNOT8 CCR4-NOT transcription complex, subunit 8
CNTN1 contactin 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DENND3 DENN/MADD domain containing 3
DET1 de-etiolated homolog 1 (Arabidopsis)
DRD5 dopamine receptor D5
DST dystonin
DSTYK dual serine/threonine and tyrosine protein kinase
DXO decapping exoribonuclease
E2F1 E2F transcription factor 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPX eosinophil peroxidase
FAM134A family with sequence similarity 134, member A
FOLR1 folate receptor 1 (adult)
FOXO1 forkhead box O1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPA33 glycoprotein A33 (transmembrane)
GREB1L growth regulation by estrogen in breast cancer-like
HLA-G major histocompatibility complex, class I, G
HPS1 Hermansky-Pudlak syndrome 1
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3
HSF2 heat shock transcription factor 2
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IL6ST interleukin 6 signal transducer
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KDM6B lysine (K)-specific demethylase 6B
KLHL25 kelch-like family member 25
LEMD3 LEM domain containing 3
LPP LIM domain containing preferred translocation partner in lipoma
LUZP4 leucine zipper protein 4
MED14 mediator complex subunit 14
MFAP2 microfibrillar-associated protein 2
MOSPD2 motile sperm domain containing 2
MPPE1 metallophosphoesterase 1
MVK mevalonate kinase
NCKIPSD NCK interacting protein with SH3 domain
NPEPL1 aminopeptidase-like 1
OBSL1 obscurin-like 1
OSBPL11 oxysterol binding protein-like 11
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLA2G12A phospholipase A2, group XIIA
POT1 protection of telomeres 1
PPAN peter pan homolog (Drosophila)
PRPH2 peripherin 2 (retinal degeneration, slow)
PSG9 pregnancy specific beta-1-glycoprotein 9
RANBP2 RAN binding protein 2
RHOH ras homolog family member H
RIC8B RIC8 guanine nucleotide exchange factor B
RNF126 ring finger protein 126
RPS2 ribosomal protein S2
SCD5 stearoyl-CoA desaturase 5
SCYL3 SCY1-like 3 (S. cerevisiae)
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC38A3 solute carrier family 38, member 3
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SPN sialophorin
STX1A syntaxin 1A (brain)
SYNRG synergin, gamma
TAOK2 TAO kinase 2
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBL1X transducin (beta)-like 1X-linked
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMPRSS5 transmembrane protease, serine 5
TNPO3 transportin 3
UBE4B ubiquitination factor E4B
UBL3 ubiquitin-like 3
UBQLN4 ubiquilin 4
UMPS uridine monophosphate synthetase
USF2 upstream transcription factor 2, c-fos interacting
VAV1 vav 1 guanine nucleotide exchange factor
VEGFB vascular endothelial growth factor B
VRK3 vaccinia related kinase 3
WAS Wiskott-Aldrich syndrome
WASL Wiskott-Aldrich syndrome-like
ZC3H13 zinc finger CCCH-type containing 13
ZNF638 zinc finger protein 638
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
AFF4 AF4/FMR2 family, member 4
AMDHD2 amidohydrolase domain containing 2
ANO10 anoctamin 10
AQP8 aquaporin 8
ASIC4 acid sensing (proton gated) ion channel family member 4
BCL7B B-cell CLL/lymphoma 7B
CCNL2 cyclin L2
CD1A CD1a molecule
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CES3 carboxylesterase 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC1A C-type lectin domain family 1, member A
CNPY3 canopy FGF signaling regulator 3
CRYAA crystallin, alpha A
CSN2 casein beta
CTNNBIP1 catenin, beta interacting protein 1
CUTC cutC copper transporter
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DNASE1L2 deoxyribonuclease I-like 2
DUSP9 dual specificity phosphatase 9
ENAH enabled homolog (Drosophila)
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM188A family with sequence similarity 188, member A
FGF6 fibroblast growth factor 6
FLNC filamin C, gamma
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMDS GDP-mannose 4,6-dehydratase
GMEB1 glucocorticoid modulatory element binding protein 1
GPR137B G protein-coupled receptor 137B
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSTM5 glutathione S-transferase mu 5
HIST1H2AI histone cluster 1, H2ai
IGKV1D-13 immunoglobulin kappa variable 1D-13
IL15RA interleukin 15 receptor, alpha
ING3 inhibitor of growth family, member 3
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IRF9 interferon regulatory factor 9
ITGAV integrin, alpha V
JAM2 junctional adhesion molecule 2
JOSD1 Josephin domain containing 1
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KRTAP1-1 keratin associated protein 1-1
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIAS lipoic acid synthetase
LINC01558 long intergenic non-protein coding RNA 1558
MAST3 microtubule associated serine/threonine kinase 3
MED23 mediator complex subunit 23
MEGF6 multiple EGF-like-domains 6
MTHFSD methenyltetrahydrofolate synthetase domain containing
NEUROG1 neurogenin 1
NPPA natriuretic peptide A
NRSN2 neurensin 2
NXPH3 neurexophilin 3
OR10H3 olfactory receptor, family 10, subfamily H, member 3
OR1F1 olfactory receptor, family 1, subfamily F, member 1
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PAX1 paired box 1
PCDHB3 protocadherin beta 3
PCP4 Purkinje cell protein 4
PCSK7 proprotein convertase subtilisin/kexin type 7
PEX12 peroxisomal biogenesis factor 12
PFAS phosphoribosylformylglycinamidine synthase
PHACTR4 phosphatase and actin regulator 4
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POU5F1B POU class 5 homeobox 1B
PRAME preferentially expressed antigen in melanoma
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
R3HDM2 R3H domain containing 2
RBP1 retinol binding protein 1, cellular
RNF185 ring finger protein 185
RORC RAR-related orphan receptor C
RPE ribulose-5-phosphate-3-epimerase
SCNM1 sodium channel modifier 1
SH3GL1 SH3-domain GRB2-like 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TM4SF5 transmembrane 4 L six family member 5
TMEM110 transmembrane protein 110
TMEM187 transmembrane protein 187
TMEM57 transmembrane protein 57
TMPRSS6 transmembrane protease, serine 6
TRAPPC12 trafficking protein particle complex 12
USP29 ubiquitin specific peptidase 29
VPS9D1 VPS9 domain containing 1
WDR13 WD repeat domain 13
WDR19 WD repeat domain 19
YEATS2 YEATS domain containing 2
YIPF1 Yip1 domain family, member 1
ZNF536 zinc finger protein 536
ZNF816 zinc finger protein 816