thioridazine-2690 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the thioridazine-2690 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANXA2 annexin A2
ANXA2P2 annexin A2 pseudogene 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ASPH aspartate beta-hydroxylase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIRC3 baculoviral IAP repeat containing 3
BTG2 BTG family, member 2
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CD70 CD70 molecule
CD83 CD83 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CREM cAMP responsive element modulator
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYFIP2 cytoplasmic FMR1 interacting protein 2
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DUSP4 dual specificity phosphatase 4
EGR2 early growth response 2
EGR3 early growth response 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
EPHA4 EPH receptor A4
F2RL2 coagulation factor II (thrombin) receptor-like 2
FAM114A1 family with sequence similarity 114, member A1
FTH1 ferritin, heavy polypeptide 1
GBP2 guanylate binding protein 2, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
GFER growth factor, augmenter of liver regeneration
GNLY granulysin
HOXD13 homeobox D13
IER3 immediate early response 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL1R1 interleukin 1 receptor, type I
IL24 interleukin 24
KLF2 Kruppel-like factor 2
KLK7 kallikrein-related peptidase 7
KYNU kynureninase
LAX1 lymphocyte transmembrane adaptor 1
LGALS3 lectin, galactoside-binding, soluble, 3
LPAR1 lysophosphatidic acid receptor 1
LZTS1 leucine zipper, putative tumor suppressor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPT microtubule-associated protein tau
MMRN2 multimerin 2
MTUS1 microtubule associated tumor suppressor 1
MUC6 mucin 6, oligomeric mucus/gel-forming
MXD4 MAX dimerization protein 4
MYO1D myosin ID
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NHLH2 nescient helix loop helix 2
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OASL 2'-5'-oligoadenylate synthetase-like
PAPOLB poly(A) polymerase beta (testis specific)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4DIP phosphodiesterase 4D interacting protein
PDGFA platelet-derived growth factor alpha polypeptide
PDX1 pancreatic and duodenal homeobox 1
PHACTR1 phosphatase and actin regulator 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRSS21 protease, serine, 21 (testisin)
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RPL23AP32 ribosomal protein L23a pseudogene 32
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC24A SEC24 family member A
SGK1 serum/glucocorticoid regulated kinase 1
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
STON1 stonin 1
STX11 syntaxin 11
THBS1 thrombospondin 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRD T cell receptor delta locus
TRIM2 tripartite motif containing 2
TRO trophinin
TUBB2A tubulin, beta 2A class IIa
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
ZFP36L1 ZFP36 ring finger protein-like 1
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
ADGRA3 adhesion G protein-coupled receptor A3
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD55 ankyrin repeat domain 55
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARMCX4 armadillo repeat containing, X-linked 4
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ASTE1 asteroid homolog 1 (Drosophila)
ATAT1 alpha tubulin acetyltransferase 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BAHCC1 BAH domain and coiled-coil containing 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BOLA1 bolA family member 1
C11ORF21 chromosome 11 open reading frame 21
C1QTNF3 C1q and tumor necrosis factor related protein 3
C8ORF33 chromosome 8 open reading frame 33
C8ORF44 chromosome 8 open reading frame 44
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCR2 chemokine (C-C motif) receptor 2
CD1D CD1d molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHST10 carbohydrate sulfotransferase 10
CRYL1 crystallin, lambda 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DHODH dihydroorotate dehydrogenase (quinone)
DPY19L2P2 DPY19L2 pseudogene 2
DUSP6 dual specificity phosphatase 6
ELP6 elongator acetyltransferase complex subunit 6
FAM50B family with sequence similarity 50, member B
FAM86B1 family with sequence similarity 86, member B1
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FLT3 fms-related tyrosine kinase 3
GPR27 G protein-coupled receptor 27
HPSE heparanase
IFNA14 interferon, alpha 14
IFT46 intraflagellar transport 46
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
LIMD2 LIM domain containing 2
LINC00339 long intergenic non-protein coding RNA 339
LRRC20 leucine rich repeat containing 20
MAGEB2 melanoma antigen family B2
MAGEH1 melanoma antigen family H1
MAPKAP1 mitogen-activated protein kinase associated protein 1
MLPH melanophilin
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MOCS3 molybdenum cofactor synthesis 3
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT10 N-acetyltransferase 10 (GCN5-related)
NFE2 nuclear factor, erythroid 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOD1 nucleotide-binding oligomerization domain containing 1
NPFFR1 neuropeptide FF receptor 1
NTSR1 neurotensin receptor 1 (high affinity)
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDLIM2 PDZ and LIM domain 2 (mystique)
PHC1 polyhomeotic homolog 1 (Drosophila)
PLA2G12A phospholipase A2, group XIIA
PLA2G15 phospholipase A2, group XV
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRF1 perforin 1 (pore forming protein)
PRKCZ protein kinase C, zeta
PRMT7 protein arginine methyltransferase 7
RAB13 RAB13, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RCL1 RNA terminal phosphate cyclase-like 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNF122 ring finger protein 122
S100A12 S100 calcium binding protein A12
SALL2 spalt-like transcription factor 2
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SERINC5 serine incorporator 5
SGMS1 sphingomyelin synthase 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLITRK5 SLIT and NTRK-like family, member 5
SPATA20 spermatogenesis associated 20
SPRYD7 SPRY domain containing 7
SYTL2 synaptotagmin-like 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THBS3 thrombospondin 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TWISTNB TWIST neighbor
TXLNG taxilin gamma
UNG uracil-DNA glycosylase
VN1R1 vomeronasal 1 receptor 1
WDR3 WD repeat domain 3
ZNF10 zinc finger protein 10
ZNF16 zinc finger protein 16
ZNF215 zinc finger protein 215
ZNF268 zinc finger protein 268
ZNF428 zinc finger protein 428
ZNF493 zinc finger protein 493
ZNHIT2 zinc finger, HIT-type containing 2