thioproperazine-2073 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the thioproperazine-2073 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
AFF4 AF4/FMR2 family, member 4
ANAPC5 anaphase promoting complex subunit 5
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
CASZ1 castor zinc finger 1
CCDC64 coiled-coil domain containing 64
CCL20 chemokine (C-C motif) ligand 20
CEL carboxyl ester lipase
CLCN3 chloride channel, voltage-sensitive 3
CNOT4 CCR4-NOT transcription complex, subunit 4
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CPT1A carnitine palmitoyltransferase 1A (liver)
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
DSC2 desmocollin 2
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
EPS8L1 EPS8-like 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FANCC Fanconi anemia, complementation group C
FCF1 FCF1 rRNA-processing protein
FCMR Fc fragment of IgM receptor
FZD1 frizzled class receptor 1
GBP1 guanylate binding protein 1, interferon-inducible
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GPR107 G protein-coupled receptor 107
GPR4 G protein-coupled receptor 4
HABP4 hyaluronan binding protein 4
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HOOK1 hook microtubule-tethering protein 1
HOXA4 homeobox A4
IFI6 interferon, alpha-inducible protein 6
IQCE IQ motif containing E
KIAA0319L KIAA0319-like
KIAA0930 KIAA0930
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LARP4 La ribonucleoprotein domain family, member 4
LAT2 linker for activation of T cells family, member 2
LDLR low density lipoprotein receptor
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIG3 ligase III, DNA, ATP-dependent
LPP LIM domain containing preferred translocation partner in lipoma
MAST2 microtubule associated serine/threonine kinase 2
MBTD1 mbt domain containing 1
MED28 mediator complex subunit 28
MFN2 mitofusin 2
MIIP migration and invasion inhibitory protein
MYRF myelin regulatory factor
NCKIPSD NCK interacting protein with SH3 domain
NOX1 NADPH oxidase 1
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OVGP1 oviductal glycoprotein 1, 120kDa
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PIDD1 p53-induced death domain protein 1
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PPP5C protein phosphatase 5, catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PTGES prostaglandin E synthase
PWAR5 Prader Willi/Angelman region RNA 5
RABGAP1 RAB GTPase activating protein 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBMS3 RNA binding motif, single stranded interacting protein 3
RGS4 regulator of G-protein signaling 4
RNFT1 ring finger protein, transmembrane 1
RPL23AP32 ribosomal protein L23a pseudogene 32
S1PR1 sphingosine-1-phosphate receptor 1
SETD6 SET domain containing 6
SETD8 SET domain containing (lysine methyltransferase) 8
SFTPB surfactant protein B
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SKI SKI proto-oncogene
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMAD5 SMAD family member 5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNIP1 Smad nuclear interacting protein 1
SOD3 superoxide dismutase 3, extracellular
SOX13 SRY (sex determining region Y)-box 13
SPATS2L spermatogenesis associated, serine-rich 2-like
SQSTM1 sequestosome 1
STS steroid sulfatase (microsomal), isozyme S
SUGP1 SURP and G patch domain containing 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFEB transcription factor EB
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM63A transmembrane protein 63A
TRIM45 tripartite motif containing 45
TROVE2 TROVE domain family, member 2
TXLNG taxilin gamma
TXNRD2 thioredoxin reductase 2
UBQLN4 ubiquilin 4
WIPF1 WAS/WASL interacting protein family, member 1
ZMYM6 zinc finger, MYM-type 6
ZNF174 zinc finger protein 174
ZNF224 zinc finger protein 224
ZNF286A zinc finger protein 286A
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADGRE2 adhesion G protein-coupled receptor E2
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ANKRD40 ankyrin repeat domain 40
APOL6 apolipoprotein L, 6
ARHGAP17 Rho GTPase activating protein 17
ATP10D ATPase, class V, type 10D
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
AXIN1 axin 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BCCIP BRCA2 and CDKN1A interacting protein
BMP15 bone morphogenetic protein 15
BRAF B-Raf proto-oncogene, serine/threonine kinase
C16ORF45 chromosome 16 open reading frame 45
C17ORF75 chromosome 17 open reading frame 75
C7ORF69 chromosome 7 open reading frame 69
C9ORF3 chromosome 9 open reading frame 3
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CADPS2 Ca++-dependent secretion activator 2
CCS copper chaperone for superoxide dismutase
CLCN5 chloride channel, voltage-sensitive 5
COG4 component of oligomeric golgi complex 4
DCAF17 DDB1 and CUL4 associated factor 17
DCLRE1A DNA cross-link repair 1A
E4F1 E4F transcription factor 1
EFNA4 ephrin-A4
EGF epidermal growth factor
EHD3 EH-domain containing 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPHX2 epoxide hydrolase 2, cytoplasmic
FAM53B family with sequence similarity 53, member B
FBXL15 F-box and leucine-rich repeat protein 15
GAREM GRB2 associated, regulator of MAPK1
GLT8D2 glycosyltransferase 8 domain containing 2
GRAMD1C GRAM domain containing 1C
HDAC7 histone deacetylase 7
HIRA histone cell cycle regulator
HIST1H3G histone cluster 1, H3g
HIST1H4J histone cluster 1, H4j
HMGB3 high mobility group box 3
HSF2BP heat shock transcription factor 2 binding protein
HYI hydroxypyruvate isomerase (putative)
IMPACT impact RWD domain protein
INF2 inverted formin, FH2 and WH2 domain containing
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KRI1 KRI1 homolog (S. cerevisiae)
KRT4 keratin 4, type II
LINS lines homolog (Drosophila)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCM3AP-AS1 MCM3AP antisense RNA 1
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
METTL2B methyltransferase like 2B
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MUC3B mucin 3B, cell surface associated
MX1 MX dynamin-like GTPase 1
NDRG4 NDRG family member 4
NOV nephroblastoma overexpressed
NPDC1 neural proliferation, differentiation and control, 1
NPM3 nucleophosmin/nucleoplasmin 3
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAQR4 progestin and adipoQ receptor family member IV
PISD phosphatidylserine decarboxylase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PMM1 phosphomannomutase 1
PMPCA peptidase (mitochondrial processing) alpha
PRR14L proline rich 14-like
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RAB3A RAB3A, member RAS oncogene family
RARS arginyl-tRNA synthetase
RCAN3 RCAN family member 3
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SEC14L2 SEC14-like 2 (S. cerevisiae)
SHPK sedoheptulokinase
SLC12A9 solute carrier family 12, member 9
SLC25A40 solute carrier family 25, member 40
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPAG7 sperm associated antigen 7
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STK16 serine/threonine kinase 16
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TEAD3 TEA domain family member 3
TFF2 trefoil factor 2
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TPK1 thiamin pyrophosphokinase 1
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TUBA3C tubulin, alpha 3c
TUBA3D tubulin, alpha 3d
UNKL unkempt family zinc finger-like
URM1 ubiquitin related modifier 1
WDR46 WD repeat domain 46
WDR91 WD repeat domain 91
ZNF276 zinc finger protein 276
ZNF701 zinc finger protein 701