thick apical ectodermal ridge Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the thickness of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme (Mammalian Phenotype Ontology, MP_0001678)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001678
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Genes

4 gene mutations causing the thick apical ectodermal ridge phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
DKK1 dickkopf WNT signaling pathway inhibitor 1
GLI3 GLI family zinc finger 3
JAG2 jagged 2
LRP4 low density lipoprotein receptor-related protein 4