thiamazole-4550 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the thiamazole-4550 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
ADGRL3 adhesion G protein-coupled receptor L3
ADGRV1 adhesion G protein-coupled receptor V1
AKR1C2 aldo-keto reductase family 1, member C2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BTG2 BTG family, member 2
C14ORF79 chromosome 14 open reading frame 79
C17ORF53 chromosome 17 open reading frame 53
C8ORF44 chromosome 8 open reading frame 44
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNO cyclin O
CEP295 centrosomal protein 295kDa
CFAP45 cilia and flagella associated protein 45
CLCN4 chloride channel, voltage-sensitive 4
CLTA clathrin, light chain A
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CUL7 cullin 7
CXORF21 chromosome X open reading frame 21
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DGCR2 DiGeorge syndrome critical region gene 2
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DSTYK dual serine/threonine and tyrosine protein kinase
EMC3 ER membrane protein complex subunit 3
ERAP1 endoplasmic reticulum aminopeptidase 1
FBXO31 F-box protein 31
FGFR4 fibroblast growth factor receptor 4
FMNL1 formin-like 1
FRMD4B FERM domain containing 4B
GAB1 GRB2-associated binding protein 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GFOD2 glucose-fructose oxidoreductase domain containing 2
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPER1 G protein-coupled estrogen receptor 1
GPNMB glycoprotein (transmembrane) nmb
GSK3A glycogen synthase kinase 3 alpha
GZMK granzyme K (granzyme 3; tryptase II)
ICOSLG inducible T-cell co-stimulator ligand
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IKZF4 IKAROS family zinc finger 4 (Eos)
IL15 interleukin 15
JAK2 Janus kinase 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
LAMP1 lysosomal-associated membrane protein 1
LIG3 ligase III, DNA, ATP-dependent
MAGEA12 melanoma antigen family A12
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK11 mitogen-activated protein kinase 11
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NF1 neurofibromin 1
NGF nerve growth factor (beta polypeptide)
NRG2 neuregulin 2
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDCD2 programmed cell death 2
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
POU5F1B POU class 5 homeobox 1B
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKG2 protein kinase, cGMP-dependent, type II
PRPH peripherin
RAB11B RAB11B, member RAS oncogene family
RAD51B RAD51 paralog B
RNGTT RNA guanylyltransferase and 5'-phosphatase
RPL23AP53 ribosomal protein L23a pseudogene 53
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SAFB2 scaffold attachment factor B2
SCARB1 scavenger receptor class B, member 1
SHOX2 short stature homeobox 2
SLAMF7 SLAM family member 7
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMO smoothened, frizzled class receptor
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
STRN striatin, calmodulin binding protein
STS steroid sulfatase (microsomal), isozyme S
TLDC1 TBC/LysM-associated domain containing 1
TLN2 talin 2
TMEM212 transmembrane protein 212
TNIK TRAF2 and NCK interacting kinase
TOP3B topoisomerase (DNA) III beta
TPM2 tropomyosin 2 (beta)
TTC12 tetratricopeptide repeat domain 12
UBE2B ubiquitin-conjugating enzyme E2B
ZFPL1 zinc finger protein-like 1
ZNF141 zinc finger protein 141
ZNF440 zinc finger protein 440
ZNF573 zinc finger protein 573
ZNF589 zinc finger protein 589
ZNF614 zinc finger protein 614

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABHD17B abhydrolase domain containing 17B
AKAP5 A kinase (PRKA) anchor protein 5
ANXA2P1 annexin A2 pseudogene 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARL14 ADP-ribosylation factor-like 14
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP7B ATPase, Cu++ transporting, beta polypeptide
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF63 chromosome 11 open reading frame 63
C17ORF70 chromosome 17 open reading frame 70
C19ORF40 chromosome 19 open reading frame 40
C9ORF40 chromosome 9 open reading frame 40
CAPN15 calpain 15
CCNE1 cyclin E1
CD101 CD101 molecule
CD68 CD68 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CNTLN centlein, centrosomal protein
CPED1 cadherin-like and PC-esterase domain containing 1
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DUSP8 dual specificity phosphatase 8
ERN2 endoplasmic reticulum to nucleus signaling 2
EVPL envoplakin
FAM186A family with sequence similarity 186, member A
FBRS fibrosin
FOXC1 forkhead box C1
GJA8 gap junction protein, alpha 8, 50kDa
GPR1 G protein-coupled receptor 1
GRTP1 growth hormone regulated TBC protein 1
HIST1H1D histone cluster 1, H1d
HIST1H2AK histone cluster 1, H2ak
HIST1H2BO histone cluster 1, H2bo
HMHA1 histocompatibility (minor) HA-1
HOXA7 homeobox A7
HOXC8 homeobox C8
IL17RB interleukin 17 receptor B
IPO8 importin 8
IQSEC2 IQ motif and Sec7 domain 2
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KRT75 keratin 75, type II
KRT86 keratin 86, type II
LAX1 lymphocyte transmembrane adaptor 1
LOC729164 hCG1732469
MAGEH1 melanoma antigen family H1
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MOCS3 molybdenum cofactor synthesis 3
MTA2 metastasis associated 1 family, member 2
MTHFSD methenyltetrahydrofolate synthetase domain containing
MX1 MX dynamin-like GTPase 1
NARFL nuclear prelamin A recognition factor-like
NAT6 N-acetyltransferase 6 (GCN5-related)
NID2 nidogen 2 (osteonidogen)
NPFFR1 neuropeptide FF receptor 1
NPM3 nucleophosmin/nucleoplasmin 3
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
ORAI3 ORAI calcium release-activated calcium modulator 3
PALM paralemmin
PCDHGB5 protocadherin gamma subfamily B, 5
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PLAC8 placenta-specific 8
POM121 POM121 transmembrane nucleoporin
PPT2 palmitoyl-protein thioesterase 2
PRB3 proline-rich protein BstNI subfamily 3
PRR14L proline rich 14-like
PRSS53 protease, serine, 53
PRSS8 protease, serine, 8
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF122 ring finger protein 122
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RUNX1-IT1 RUNX1 intronic transcript 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCUBE3 signal peptide, CUB domain, EGF-like 3
SH3GL2 SH3-domain GRB2-like 2
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLMO1 slowmo homolog 1 (Drosophila)
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SRD5A3 steroid 5 alpha-reductase 3
SUGCT succinyl-CoA:glutarate-CoA transferase
SYNGR3 synaptogyrin 3
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRIM21 tripartite motif containing 21
TRIM66 tripartite motif containing 66
TTLL1 tubulin tyrosine ligase-like family member 1
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USB1 U6 snRNA biogenesis 1
USP32 ubiquitin specific peptidase 32
YOD1 YOD1 deubiquitinase
ZC3H12A zinc finger CCCH-type containing 12A
ZNF37BP zinc finger protein 37B, pseudogene
ZNF41 zinc finger protein 41