theophylline-4228 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the theophylline-4228 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ACSM3 acyl-CoA synthetase medium-chain family member 3
ACTN2 actinin, alpha 2
ADGRA2 adhesion G protein-coupled receptor A2
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
ALOX5 arachidonate 5-lipoxygenase
APAF1 apoptotic peptidase activating factor 1
ARTN artemin
ASPN asporin
ATXN7L1 ataxin 7-like 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2 B-cell CLL/lymphoma 2
BTBD18 BTB (POZ) domain containing 18
CCDC177 coiled-coil domain containing 177
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CELF2 CUGBP, Elav-like family member 2
CEMIP cell migration inducing protein, hyaluronan binding
CHODL chondrolectin
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNTFR ciliary neurotrophic factor receptor
COL4A6 collagen, type IV, alpha 6
CSF1 colony stimulating factor 1 (macrophage)
DAPK2 death-associated protein kinase 2
DCTN2 dynactin 2 (p50)
DTNA dystrobrevin, alpha
FLT1 fms-related tyrosine kinase 1
FOXN3 forkhead box N3
GAL3ST4 galactose-3-O-sulfotransferase 4
GIMAP5 GTPase, IMAP family member 5
GK3P glycerol kinase 3 pseudogene
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPATCH4 G patch domain containing 4
GPM6B glycoprotein M6B
GPR21 G protein-coupled receptor 21
GPSM3 G-protein signaling modulator 3
HIC2 hypermethylated in cancer 2
HOXA1 homeobox A1
IGFBP7 insulin-like growth factor binding protein 7
IL1RN interleukin 1 receptor antagonist
IL22RA1 interleukin 22 receptor, alpha 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA1024 KIAA1024
LIMCH1 LIM and calponin homology domains 1
MAP1B microtubule-associated protein 1B
MAPK11 mitogen-activated protein kinase 11
MARK1 MAP/microtubule affinity-regulating kinase 1
MCM3AP minichromosome maintenance complex component 3 associated protein
MEFV Mediterranean fever
MFAP3L microfibrillar-associated protein 3-like
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MLX MLX, MAX dimerization protein
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MST1 macrophage stimulating 1
MVB12B multivesicular body subunit 12B
NOS1 nitric oxide synthase 1 (neuronal)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NUP54 nucleoporin 54kDa
PAOX polyamine oxidase (exo-N4-amino)
PAPOLG poly(A) polymerase gamma
PDCD2 programmed cell death 2
PDE4D phosphodiesterase 4D, cAMP-specific
PKP4 plakophilin 4
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POFUT1 protein O-fucosyltransferase 1
PQLC2 PQ loop repeat containing 2
PRODH2 proline dehydrogenase (oxidase) 2
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RIN3 Ras and Rab interactor 3
RUNX1 runt-related transcription factor 1
SARM1 sterile alpha and TIR motif containing 1
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SMAD4 SMAD family member 4
SP100 SP100 nuclear antigen
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
ST7L suppression of tumorigenicity 7 like
SUGP1 SURP and G patch domain containing 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TESK1 testis-specific kinase 1
THBD thrombomodulin
THOC5 THO complex 5
TLE2 transducin-like enhancer of split 2
TMOD1 tropomodulin 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNXB tenascin XB
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TUBA3C tubulin, alpha 3c
USP22 ubiquitin specific peptidase 22
VNN2 vanin 2
VWA5A von Willebrand factor A domain containing 5A
WDR55 WD repeat domain 55
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF219 zinc finger protein 219
ZNF225 zinc finger protein 225
ZNF230 zinc finger protein 230
ZNF287 zinc finger protein 287

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACE angiotensin I converting enzyme
ADAM23 ADAM metallopeptidase domain 23
ADGRB2 adhesion G protein-coupled receptor B2
ADGRE2 adhesion G protein-coupled receptor E2
C22ORF46 chromosome 22 open reading frame 46
CAMKMT calmodulin-lysine N-methyltransferase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CLCA1 chloride channel accessory 1
CNGB3 cyclic nucleotide gated channel beta 3
COMP cartilage oligomeric matrix protein
CPNE7 copine VII
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CUZD1 CUB and zona pellucida-like domains 1
CXORF21 chromosome X open reading frame 21
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DOK5 docking protein 5
ELP6 elongator acetyltransferase complex subunit 6
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM86C1 family with sequence similarity 86, member C1
FGF23 fibroblast growth factor 23
FKBP5 FK506 binding protein 5
FRMPD1 FERM and PDZ domain containing 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GIF gastric intrinsic factor (vitamin B synthesis)
GPR3 G protein-coupled receptor 3
GPR75 G protein-coupled receptor 75
GRM4 glutamate receptor, metabotropic 4
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HAMP hepcidin antimicrobial peptide
HESX1 HESX homeobox 1
HIST1H1D histone cluster 1, H1d
HIST1H2BO histone cluster 1, H2bo
HIST1H4D histone cluster 1, H4d
HOXC10 homeobox C10
HPR haptoglobin-related protein
HSPA1L heat shock 70kDa protein 1-like
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFNA17 interferon, alpha 17
IL36RN interleukin 36 receptor antagonist
IQSEC2 IQ motif and Sec7 domain 2
JUNB jun B proto-oncogene
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDM5C lysine (K)-specific demethylase 5C
KDM8 lysine (K)-specific demethylase 8
KIAA1456 KIAA1456
KRT31 keratin 31, type I
LAX1 lymphocyte transmembrane adaptor 1
LIME1 Lck interacting transmembrane adaptor 1
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMO2 LIM domain only 2 (rhombotin-like 1)
LPAR4 lysophosphatidic acid receptor 4
MTA2 metastasis associated 1 family, member 2
MTMR11 myotubularin related protein 11
MTSS1L metastasis suppressor 1-like
MYO15A myosin XVA
OLFML2A olfactomedin-like 2A
OSBP2 oxysterol binding protein 2
PAIP2B poly(A) binding protein interacting protein 2B
PDE12 phosphodiesterase 12
PHEX phosphate regulating endopeptidase homolog, X-linked
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRKG2 protein kinase, cGMP-dependent, type II
PRM2 protamine 2
PRR15L proline rich 15-like
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK6 protein tyrosine kinase 6
QPCTL glutaminyl-peptide cyclotransferase-like
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RAPSN receptor-associated protein of the synapse
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPA4 replication protein A4, 30kDa
SCGB2A2 secretoglobin, family 2A, member 2
SCIN scinderin
SCUBE3 signal peptide, CUB domain, EGF-like 3
SGK2 serum/glucocorticoid regulated kinase 2
SLC16A6 solute carrier family 16, member 6
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SOX12 SRY (sex determining region Y)-box 12
SPATA1 spermatogenesis associated 1
SSBP3 single stranded DNA binding protein 3
STEAP4 STEAP family member 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TESPA1 thymocyte expressed, positive selection associated 1
TEX15 testis expressed 15
TLN1 talin 1
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNS2 tensin 2
TRABD TraB domain containing
VEGFB vascular endothelial growth factor B
WNT1 wingless-type MMTV integration site family, member 1
ZNF222 zinc finger protein 222
ZNF415 zinc finger protein 415
ZNF480 zinc finger protein 480