thapsigargin-7103 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the thapsigargin-7103 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
AKAP17A A kinase (PRKA) anchor protein 17A
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
C1ORF116 chromosome 1 open reading frame 116
CDC6 cell division cycle 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN1 claudin 1
CRELD1 cysteine-rich with EGF-like domains 1
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLC1 DLC1 Rho GTPase activating protein
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EDC3 enhancer of mRNA decapping 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FICD FIC domain containing
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GTPBP2 GTP binding protein 2
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HYOU1 hypoxia up-regulated 1
IL1RL1 interleukin 1 receptor-like 1
IL24 interleukin 24
IL6 interleukin 6
INHBA inhibin, beta A
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT34 keratin 34, type I
LARP6 La ribonucleoprotein domain family, member 6
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANF mesencephalic astrocyte-derived neurotrophic factor
NFIL3 nuclear factor, interleukin 3 regulated
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OASL 2'-5'-oligoadenylate synthetase-like
OSBP oxysterol binding protein
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA4 protein disulfide isomerase family A, member 4
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
QKI QKI, KH domain containing, RNA binding
RASAL2 RAS protein activator like 2
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RND1 Rho family GTPase 1
RSRC2 arginine/serine-rich coiled-coil 2
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TGFB2 transforming growth factor, beta 2
THBD thrombomodulin
TMEM50B transmembrane protein 50B
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIB3 tribbles pseudokinase 3
TSPYL2 TSPY-like 2
TUBA3C tubulin, alpha 3c
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
XBP1 X-box binding protein 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165
ZNF419 zinc finger protein 419

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADCY6 adenylate cyclase 6
ADRB2 adrenoceptor beta 2, surface
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ALG6 ALG6, alpha-1,3-glucosyltransferase
APMAP adipocyte plasma membrane associated protein
ASAP1-IT1 ASAP1 intronic transcript 1
ASB13 ankyrin repeat and SOCS box containing 13
B3GNT1
BAG3 BCL2-associated athanogene 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1
CCNE2 cyclin E2
CD302 CD302 molecule
CD59 CD59 molecule, complement regulatory protein
CERK ceramide kinase
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLDN4 claudin 4
COL6A3 collagen, type VI, alpha 3
CROT carnitine O-octanoyltransferase
CRYZ crystallin, zeta (quinone reductase)
DIXDC1 DIX domain containing 1
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DUSP6 dual specificity phosphatase 6
E2F8 E2F transcription factor 8
EN1 engrailed homeobox 1
EPN3 epsin 3
FAM172A family with sequence similarity 172, member A
FHOD1 formin homology 2 domain containing 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRPR gastrin-releasing peptide receptor
HMHA1 histocompatibility (minor) HA-1
HOXA10 homeobox A10
HOXA4 homeobox A4
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
INHBB inhibin, beta B
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITPKB inositol-trisphosphate 3-kinase B
KIAA0895 KIAA0895
KLHL3 kelch-like family member 3
LAMA3 laminin, alpha 3
LAMA5 laminin, alpha 5
LMNB1 lamin B1
LPAR6 lysophosphatidic acid receptor 6
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LYPD3 LY6/PLAUR domain containing 3
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MBTPS2 membrane-bound transcription factor peptidase, site 2
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MVP major vault protein
MXD3 MAX dimerization protein 3
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NDRG4 NDRG family member 4
NPY1R neuropeptide Y receptor Y1
NTSR1 neurotensin receptor 1 (high affinity)
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PALMD palmdelphin
PCYOX1 prenylcysteine oxidase 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLAT plasminogen activator, tissue
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PPT2 palmitoyl-protein thioesterase 2
PRAME preferentially expressed antigen in melanoma
PRKX protein kinase, X-linked
PROS1 protein S (alpha)
PTK7 protein tyrosine kinase 7 (inactive)
RAB3A RAB3A, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RIPK4 receptor-interacting serine-threonine kinase 4
RPP25 ribonuclease P/MRP 25kDa subunit
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SHROOM2 shroom family member 2
SIGLEC15 sialic acid binding Ig-like lectin 15
SOX9 SRY (sex determining region Y)-box 9
SPATA2L spermatogenesis associated 2-like
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STIM1 stromal interaction molecule 1
TBXAS1 thromboxane A synthase 1 (platelet)
TGFBR3 transforming growth factor, beta receptor III
TMEM30A transmembrane protein 30A
TPST2 tyrosylprotein sulfotransferase 2
TRIB2 tribbles pseudokinase 2
TSPAN12 tetraspanin 12
TSPAN15 tetraspanin 15
UNC119B unc-119 homolog B (C. elegans)
VANGL1 VANGL planar cell polarity protein 1
VASH2 vasohibin 2
VSIG10 V-set and immunoglobulin domain containing 10
WRB tryptophan rich basic protein
ZCCHC2 zinc finger, CCHC domain containing 2