thalidomide-2258 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the thalidomide-2258 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ACPP acid phosphatase, prostate
AMACR alpha-methylacyl-CoA racemase
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
BLVRA biliverdin reductase A
BMP10 bone morphogenetic protein 10
BST2 bone marrow stromal cell antigen 2
C11ORF16 chromosome 11 open reading frame 16
CAPN6 calpain 6
CD4 CD4 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CLCN7 chloride channel, voltage-sensitive 7
CLPS colipase, pancreatic
CLTA clathrin, light chain A
CNTLN centlein, centrosomal protein
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSF1R colony stimulating factor 1 receptor
CTSF cathepsin F
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DMBT1 deleted in malignant brain tumors 1
DRD2 dopamine receptor D2
EDA ectodysplasin A
EGFR epidermal growth factor receptor
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELF5 E74-like factor 5 (ets domain transcription factor)
EXPH5 exophilin 5
FGF4 fibroblast growth factor 4
FPR1 formyl peptide receptor 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GJA4 gap junction protein, alpha 4, 37kDa
GKN1 gastrokine 1
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
HDAC11 histone deacetylase 11
HEMK1 HemK methyltransferase family member 1
IDI2-AS1 IDI2 antisense RNA 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNMB2 potassium channel subfamily M regulatory beta subunit 2
KLHL25 kelch-like family member 25
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRP1B low density lipoprotein receptor-related protein 1B
LTB4R leukotriene B4 receptor
MAP4 microtubule-associated protein 4
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MEGF6 multiple EGF-like-domains 6
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP13 matrix metallopeptidase 13
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NCF4 neutrophil cytosolic factor 4, 40kDa
NDN necdin, melanoma antigen (MAGE) family member
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPIPB3 nuclear pore complex interacting protein family, member B3
NPTXR neuronal pentraxin receptor
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR5A2 nuclear receptor subfamily 5, group A, member 2
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PAIP2B poly(A) binding protein interacting protein 2B
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PQBP1 polyglutamine binding protein 1
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTCRA pre T-cell antigen receptor alpha
RASA3 RAS p21 protein activator 3
RERE arginine-glutamic acid dipeptide (RE) repeats
RHOH ras homolog family member H
RPL35A ribosomal protein L35a
RXRB retinoid X receptor, beta
SERHL2 serine hydrolase-like 2
SFTPA2 surfactant protein A2
SIM2 single-minded family bHLH transcription factor 2
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SMC4 structural maintenance of chromosomes 4
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SRGN serglycin
SULT4A1 sulfotransferase family 4A, member 1
SYCE1L synaptonemal complex central element protein 1-like
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
SYT13 synaptotagmin XIII
TBX2 T-box 2
TEF thyrotrophic embryonic factor
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNS1 tensin 1
TP53I11 tumor protein p53 inducible protein 11
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM3 tripartite motif containing 3
TRPC1 transient receptor potential cation channel, subfamily C, member 1
WDR55 WD repeat domain 55
ZEB1 zinc finger E-box binding homeobox 1
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
AHDC1 AT hook, DNA binding motif, containing 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BLM Bloom syndrome, RecQ helicase-like
BMP4 bone morphogenetic protein 4
C17ORF80 chromosome 17 open reading frame 80
CAMK1 calcium/calmodulin-dependent protein kinase I
CCDC121 coiled-coil domain containing 121
CCDC132 coiled-coil domain containing 132
CENPO centromere protein O
CLSPN claspin
CNTN1 contactin 1
CPPED1 calcineurin-like phosphoesterase domain containing 1
DCAF13 DDB1 and CUL4 associated factor 13
DCP1A decapping mRNA 1A
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EPPK1 epiplakin 1
ERCC4 excision repair cross-complementation group 4
F2R coagulation factor II (thrombin) receptor
FAM188A family with sequence similarity 188, member A
FAM189A2 family with sequence similarity 189, member A2
FAM204A family with sequence similarity 204, member A
FOLR1 folate receptor 1 (adult)
GMEB1 glucocorticoid modulatory element binding protein 1
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GTPBP2 GTP binding protein 2
GUSBP3 glucuronidase, beta pseudogene 3
HOXC10 homeobox C10
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL12RB1 interleukin 12 receptor, beta 1
IL17RA interleukin 17 receptor A
IPO8 importin 8
IRF2BP1 interferon regulatory factor 2 binding protein 1
KDM8 lysine (K)-specific demethylase 8
KIAA0754 KIAA0754
KIF3A kinesin family member 3A
LAMP3 lysosomal-associated membrane protein 3
MAST3 microtubule associated serine/threonine kinase 3
MEFV Mediterranean fever
MRPL52 mitochondrial ribosomal protein L52
N4BP3 NEDD4 binding protein 3
NDRG4 NDRG family member 4
NIPAL2 NIPA-like domain containing 2
OLFML2A olfactomedin-like 2A
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PAQR6 progestin and adipoQ receptor family member VI
PARD6B par-6 family cell polarity regulator beta
PCDHA6 protocadherin alpha 6
PGBD5 piggyBac transposable element derived 5
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD3 phospholipase D family, member 3
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POMT2 protein-O-mannosyltransferase 2
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRDM16 PR domain containing 16
PTPRU protein tyrosine phosphatase, receptor type, U
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB3A RAB3A, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SCAI suppressor of cancer cell invasion
SH3BGR SH3 domain binding glutamate-rich protein
SKI SKI proto-oncogene
SLC16A6 solute carrier family 16, member 6
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SOX12 SRY (sex determining region Y)-box 12
SPANXC SPANX family, member C
SPIN1 spindlin 1
SPRY2 sprouty homolog 2 (Drosophila)
STX1A syntaxin 1A (brain)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBC1D17 TBC1 domain family, member 17
TBKBP1 TBK1 binding protein 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM121 transmembrane protein 121
TMEM184C transmembrane protein 184C
TMPRSS4 transmembrane protease, serine 4
TRDMT1 tRNA aspartic acid methyltransferase 1
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTLL1 tubulin tyrosine ligase-like family member 1
UNC119 unc-119 homolog (C. elegans)
USB1 U6 snRNA biogenesis 1
VASH2 vasohibin 2
VEGFC vascular endothelial growth factor C
ZBTB44 zinc finger and BTB domain containing 44
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF134 zinc finger protein 134
ZNF668 zinc finger protein 668
ZNF76 zinc finger protein 76
ZNF768 zinc finger protein 768
ZNF862 zinc finger protein 862