tetryzoline-6069 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the tetryzoline-6069 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADCY10 adenylate cyclase 10 (soluble)
ADD2 adducin 2 (beta)
AGTR1 angiotensin II receptor, type 1
AIM1L absent in melanoma 1-like
ALK anaplastic lymphoma receptor tyrosine kinase
AQP7 aquaporin 7
ASIC2 acid sensing (proton gated) ion channel 2
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BHMT2 betaine--homocysteine S-methyltransferase 2
BIN1 bridging integrator 1
BMP3 bone morphogenetic protein 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C7ORF69 chromosome 7 open reading frame 69
C9ORF16 chromosome 9 open reading frame 16
CALD1 caldesmon 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD6 CD6 molecule
CLCN4 chloride channel, voltage-sensitive 4
COL10A1 collagen, type X, alpha 1
COLGALT2 collagen beta(1-O)galactosyltransferase 2
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CRHR2 corticotropin releasing hormone receptor 2
CRISP2 cysteine-rich secretory protein 2
CRTC1 CREB regulated transcription coactivator 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSZ cathepsin Z
CXXC4 CXXC finger protein 4
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DCAF4 DDB1 and CUL4 associated factor 4
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FZD9 frizzled class receptor 9
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABARAPL1 GABA(A) receptor-associated protein like 1
GAP43 growth associated protein 43
GPR39 G protein-coupled receptor 39
HGD homogentisate 1,2-dioxygenase
HIPK2 homeodomain interacting protein kinase 2
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXA7 homeobox A7
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
IL6 interleukin 6
INSR insulin receptor
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIAA0319 KIAA0319
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LAMA2 laminin, alpha 2
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LPL lipoprotein lipase
LRP2 low density lipoprotein receptor-related protein 2
MBD2 methyl-CpG binding domain protein 2
MEG3 maternally expressed 3 (non-protein coding)
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MSR1 macrophage scavenger receptor 1
MST1 macrophage stimulating 1
MUC3B mucin 3B, cell surface associated
MUC4 mucin 4, cell surface associated
MUSK muscle, skeletal, receptor tyrosine kinase
NF2 neurofibromin 2 (merlin)
NPPA natriuretic peptide A
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PCDHB17P protocadherin beta 17 pseudogene
PDE10A phosphodiesterase 10A
PDE4C phosphodiesterase 4C, cAMP-specific
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G5 phospholipase A2, group V
PLXDC1 plexin domain containing 1
POU6F1 POU class 6 homeobox 1
PPARA peroxisome proliferator-activated receptor alpha
PSG4 pregnancy specific beta-1-glycoprotein 4
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPH3A rabphilin 3A
SCRG1 stimulator of chondrogenesis 1
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
SERHL2 serine hydrolase-like 2
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SEZ6L seizure related 6 homolog (mouse)-like
SH2D3A SH2 domain containing 3A
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STEAP4 STEAP family member 4
SYN3 synapsin III
TAGLN3 transgelin 3
TAPT1 transmembrane anterior posterior transformation 1
TNNT2 troponin T type 2 (cardiac)
TRIM10 tripartite motif containing 10
TRIM15 tripartite motif containing 15
YY2 YY2 transcription factor
ZNF44 zinc finger protein 44
ZNF749 zinc finger protein 749

decreased expression

Symbol Name
AEN apoptosis enhancing nuclease
AGMAT agmatine ureohydrolase (agmatinase)
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
AUTS2 autism susceptibility candidate 2
B9D2 B9 protein domain 2
BCL9 B-cell CLL/lymphoma 9
CCDC186 coiled-coil domain containing 186
CDT1 chromatin licensing and DNA replication factor 1
CHKB choline kinase beta
CHML choroideremia-like (Rab escort protein 2)
CHRM3 cholinergic receptor, muscarinic 3
CLCN5 chloride channel, voltage-sensitive 5
CLDN15 claudin 15
CNGB3 cyclic nucleotide gated channel beta 3
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CSF1R colony stimulating factor 1 receptor
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DEAF1 DEAF1 transcription factor
DHRS7B dehydrogenase/reductase (SDR family) member 7B
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFNA3 ephrin-A3
EGFL7 EGF-like-domain, multiple 7
EGLN3 egl-9 family hypoxia-inducible factor 3
EHMT1 euchromatic histone-lysine N-methyltransferase 1
FAM169A family with sequence similarity 169, member A
FAM198B family with sequence similarity 198, member B
FAM86C1 family with sequence similarity 86, member C1
FKBP10 FK506 binding protein 10, 65 kDa
FOXN2 forkhead box N2
FPGS folylpolyglutamate synthase
FSTL3 follistatin-like 3 (secreted glycoprotein)
GALT galactose-1-phosphate uridylyltransferase
GMEB1 glucocorticoid modulatory element binding protein 1
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HDAC11 histone deacetylase 11
HIST1H1D histone cluster 1, H1d
HIST1H4D histone cluster 1, H4d
HSPA1L heat shock 70kDa protein 1-like
IL12RB1 interleukin 12 receptor, beta 1
IQCG IQ motif containing G
ITPKB inositol-trisphosphate 3-kinase B
KDM7A lysine (K)-specific demethylase 7A
KDM8 lysine (K)-specific demethylase 8
KPNA5 karyopherin alpha 5 (importin alpha 6)
LOC730101 uncharacterized LOC730101
LZTS3 leucine zipper, putative tumor suppressor family member 3
MANSC1 MANSC domain containing 1
MAST3 microtubule associated serine/threonine kinase 3
MATK megakaryocyte-associated tyrosine kinase
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MMP2 matrix metallopeptidase 2
MYO9A myosin IXA
NKAIN1 Na+/K+ transporting ATPase interacting 1
NRSN2 neurensin 2
NT5DC3 5'-nucleotidase domain containing 3
ONECUT2 one cut homeobox 2
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PGBD5 piggyBac transposable element derived 5
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PITX2 paired-like homeodomain 2
PMCH pro-melanin-concentrating hormone
PPARG peroxisome proliferator-activated receptor gamma
PRF1 perforin 1 (pore forming protein)
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
RAB5B RAB5B, member RAS oncogene family
RGS19 regulator of G-protein signaling 19
RLN1 relaxin 1
RPS14P3 ribosomal protein S14 pseudogene 3
RPUSD2 RNA pseudouridylate synthase domain containing 2
SDC3 syndecan 3
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC22A14 solute carrier family 22, member 14
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
STARD3 StAR-related lipid transfer (START) domain containing 3
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBC1D17 TBC1 domain family, member 17
TGFBR1 transforming growth factor, beta receptor 1
TICAM1 toll-like receptor adaptor molecule 1
TMEM121 transmembrane protein 121
TMEM209 transmembrane protein 209
TMEM62 transmembrane protein 62
TOM1 target of myb1 (chicken)
TPST2 tyrosylprotein sulfotransferase 2
TUBA3C tubulin, alpha 3c
UNC119 unc-119 homolog (C. elegans)
UPP1 uridine phosphorylase 1
USP19 ubiquitin specific peptidase 19
WDR25 WD repeat domain 25
WLS wntless Wnt ligand secretion mediator
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF205 zinc finger protein 205
ZNF770 zinc finger protein 770