tetraethylenepentamine-406 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the tetraethylenepentamine-406 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ANKRD26 ankyrin repeat domain 26
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
AVEN apoptosis, caspase activation inhibitor
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BICD1 bicaudal D homolog 1 (Drosophila)
C19ORF66 chromosome 19 open reading frame 66
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CDC25C cell division cycle 25C
CLCN7 chloride channel, voltage-sensitive 7
CLEC1A C-type lectin domain family 1, member A
CPOX coproporphyrinogen oxidase
CST6 cystatin E/M
CTAGE9 CTAGE family, member 9
DAXX death-domain associated protein
DCAF15 DDB1 and CUL4 associated factor 15
DENND3 DENN/MADD domain containing 3
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DIO2 deiodinase, iodothyronine, type II
ECE1 endothelin converting enzyme 1
EFNB3 ephrin-B3
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM153A family with sequence similarity 153, member A
FAM76A family with sequence similarity 76, member A
FGFR1 fibroblast growth factor receptor 1
FGL1 fibrinogen-like 1
FNBP1L formin binding protein 1-like
FOSL1 FOS-like antigen 1
FSCN3 fascin actin-bundling protein 3, testicular
FUBP1 far upstream element (FUSE) binding protein 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GAS7 growth arrest-specific 7
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GNRH2 gonadotropin-releasing hormone 2
GRHPR glyoxylate reductase/hydroxypyruvate reductase
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2I general transcription factor IIi
H2AFY2 H2A histone family, member Y2
HDAC2 histone deacetylase 2
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IL12RB1 interleukin 12 receptor, beta 1
IL2RA interleukin 2 receptor, alpha
ITGB5 integrin, beta 5
JOSD1 Josephin domain containing 1
KIFC1 kinesin family member C1
KLHL3 kelch-like family member 3
LMBR1L limb development membrane protein 1-like
LPIN2 lipin 2
LY86 lymphocyte antigen 86
MED14 mediator complex subunit 14
MED7 mediator complex subunit 7
MRPS15 mitochondrial ribosomal protein S15
MTMR3 myotubularin related protein 3
MVB12B multivesicular body subunit 12B
MYL10 myosin, light chain 10, regulatory
MYO7B myosin VIIB
NCKIPSD NCK interacting protein with SH3 domain
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NELL2 NEL-like 2 (chicken)
NPAT nuclear protein, ataxia-telangiectasia locus
NREP neuronal regeneration related protein
NRGN neurogranin (protein kinase C substrate, RC3)
OCA2 oculocutaneous albinism II
ORC5 origin recognition complex, subunit 5
PCM1 pericentriolar material 1
PDCD2 programmed cell death 2
PHC1 polyhomeotic homolog 1 (Drosophila)
PLA2G10 phospholipase A2, group X
PLA2G12A phospholipase A2, group XIIA
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
PRKG2 protein kinase, cGMP-dependent, type II
PRPF31 pre-mRNA processing factor 31
PTPRT protein tyrosine phosphatase, receptor type, T
PVR poliovirus receptor
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RBM5 RNA binding motif protein 5
RPLP2 ribosomal protein, large, P2
RUNDC3A RUN domain containing 3A
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SRPK2 SRSF protein kinase 2
STK19 serine/threonine kinase 19
T T, brachyury homolog (mouse)
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM87A transmembrane protein 87A
TMPRSS6 transmembrane protease, serine 6
TRIO trio Rho guanine nucleotide exchange factor
TSPAN3 tetraspanin 3
TTI1 TELO2 interacting protein 1
UBE3A ubiquitin protein ligase E3A
UBL3 ubiquitin-like 3
USH1C Usher syndrome 1C (autosomal recessive, severe)

decreased expression

Symbol Name
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ATXN2 ataxin 2
C9ORF40 chromosome 9 open reading frame 40
CA9 carbonic anhydrase IX
CCDC71 coiled-coil domain containing 71
CD177 CD177 molecule
CD82 CD82 molecule
CDK18 cyclin-dependent kinase 18
CGA glycoprotein hormones, alpha polypeptide
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CLPS colipase, pancreatic
CNGB3 cyclic nucleotide gated channel beta 3
CPTP ceramide-1-phosphate transfer protein
CTC1 CTS telomere maintenance complex component 1
CTRB2 chymotrypsinogen B2
CTSG cathepsin G
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYSLTR2 cysteinyl leukotriene receptor 2
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DGKD diacylglycerol kinase, delta 130kDa
DLK2 delta-like 2 homolog (Drosophila)
ELMO3 engulfment and cell motility 3
EVPL envoplakin
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1
GLMN glomulin, FKBP associated protein
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HMGA2 high mobility group AT-hook 2
HOXC5 homeobox C5
IGKV1D-13 immunoglobulin kappa variable 1D-13
IL36RN interleukin 36 receptor antagonist
IL4R interleukin 4 receptor
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IRF8 interferon regulatory factor 8
JMJD4 jumonji domain containing 4
KREMEN2 kringle containing transmembrane protein 2
LENEP lens epithelial protein
LGMN legumain
LINC00339 long intergenic non-protein coding RNA 339
LOC100286895 cell division cycle 27 homolog pseudogene
LOXL1 lysyl oxidase-like 1
LRRC20 leucine rich repeat containing 20
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MARC1 mitochondrial amidoxime reducing component 1
MCHR1 melanin-concentrating hormone receptor 1
MFSD12 major facilitator superfamily domain containing 12
MTERF1 mitochondrial transcription termination factor 1
MTERF4 mitochondrial transcription termination factor 4
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NAV2 neuron navigator 2
NCKAP1L NCK-associated protein 1-like
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
NXPH4 neurexophilin 4
ONECUT2 one cut homeobox 2
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PADI1 peptidyl arginine deiminase, type I
PAIP2B poly(A) binding protein interacting protein 2B
PARP8 poly (ADP-ribose) polymerase family, member 8
PCDHB6 protocadherin beta 6
PCSK7 proprotein convertase subtilisin/kexin type 7
PECR peroxisomal trans-2-enoyl-CoA reductase
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G15 phospholipase A2, group XV
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
PLXNB3 plexin B3
POGLUT1 protein O-glucosyltransferase 1
POU5F1B POU class 5 homeobox 1B
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRAME preferentially expressed antigen in melanoma
PRDM14 PR domain containing 14
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PSG5 pregnancy specific beta-1-glycoprotein 5
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PVRIG poliovirus receptor related immunoglobulin domain containing
S100A1 S100 calcium binding protein A1
SAMHD1 SAM domain and HD domain 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD3 SERTA domain containing 3
SH3BP1 SH3-domain binding protein 1
SIL1 SIL1 nucleotide exchange factor
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SPAG4 sperm associated antigen 4
STAG3 stromal antigen 3
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNGR4 synaptogyrin 4
TCEA2 transcription elongation factor A (SII), 2
TMED1 transmembrane emp24 protein transport domain containing 1
TMEM35 transmembrane protein 35
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
UEVLD UEV and lactate/malate dehyrogenase domains
WNT2 wingless-type MMTV integration site family member 2
WNT3 wingless-type MMTV integration site family, member 3
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBED1 zinc finger, BED-type containing 1
ZFP36 ZFP36 ring finger protein
ZNHIT2 zinc finger, HIT-type containing 2
ZNRF4 zinc and ring finger 4